{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:55:11Z","timestamp":1792896911399,"version":"4.5.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"466","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA225837"],"award-info":[{"award-number":["R01CA225837"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010346","name":"University of Colorado Denver","doi-asserted-by":"publisher","award":["Start-up fund"],"award-info":[{"award-number":["Start-up fund"]}],"id":[{"id":"10.13039\/100010346","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2018,11,7]]},"abstract":"<jats:p>\n            <jats:sup>68<\/jats:sup>\n            Ga-DOTA-GGNle-CycMSH\n            <jats:sub>hex<\/jats:sub>\n            , a radiolabeled melanocortin-1 receptor\u2013targeting imaging probe, detects melanoma in first-in-human testing.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.aau4445","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T19:05:44Z","timestamp":1541617544000},"source":"Crossref","is-referenced-by-count":54,"title":["<sup>68<\/sup>\n            Ga-DOTA-GGNle-CycMSH\n            <sub>hex<\/sub>\n            targets the melanocortin-1 receptor for melanoma imaging"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0687-6145","authenticated-orcid":true,"given":"Jianquan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Colorado Denver, Aurora, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingli","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Colorado Denver, Aurora, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Colorado Denver, Aurora, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-484X","authenticated-orcid":true,"given":"Thomas","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-8260","authenticated-orcid":true,"given":"Clemens","family":"Kratochwil","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Heidelberg, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-4403","authenticated-orcid":true,"given":"Yubin","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Colorado Denver, Aurora, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041245"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-005-0002-5"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112302"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1927"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0105"},{"key":"e_1_3_1_10_2","first-page":"2545","article-title":"Interaction on an \u03b1-melanocyte stimulating hormone-diptheria toxin fusion protein with melanotropin receptors in human metastases","volume":"52","author":"Tatro J. B.","year":"1992","unstructured":"J. B. Tatro, Z. Wen, M. L. Entwistle, M. B. Atkins, T. J. Smith, S. Reichlin, J. R. Murphy, Interaction on an \u03b1-melanocyte stimulating hormone-diptheria toxin fusion protein with melanotropin receptors in human metastases. Cancer Res. 52, 2545\u20132548 (1992).","journal-title":"Cancer Res."},{"key":"e_1_3_1_11_2","first-page":"6352","article-title":"Characterization of receptors for \u03b1-melanocyte-stimulating hormone on human melanoma cells","volume":"49","author":"Siegrist W.","year":"1989","unstructured":"W. Siegrist, F. Solca, S. Stutz, L. Giuffr\u00e8, S. Carrel, J. Girard, A. N. Eberle, Characterization of receptors for \u03b1-melanocyte-stimulating hormone on human melanoma cells. Cancer Res. 49, 6352\u20136358 (1989).","journal-title":"Cancer Res."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-121-5-1900"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.92.4.551"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041048"},{"key":"e_1_3_1_15_2","first-page":"5649","article-title":"Melanoma-targeting properties of 99mTechnetium-labeled cyclic \u03b1-melanocyte-stimulating hormone peptide analogues","volume":"60","author":"Chen J.","year":"2000","unstructured":"J. Chen, Z. Cheng, T. J. Hoffman, S. S. Jurisson, T. P. Quinn, Melanoma-targeting properties of 99mTechnetium-labeled cyclic \u03b1-melanocyte-stimulating hormone peptide analogues. Cancer Res. 60, 5649\u20135658 (2000).","journal-title":"Cancer Res."},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc034069i"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2009.01.003"},{"key":"e_1_3_1_18_2","first-page":"73","article-title":"99mTc and 111In labeled \u03b1-melanocyte stimulating hormone peptides as imaging probes for primary and pulmonary metastatic melanoma detection","volume":"48","author":"Miao Y.","year":"2007","unstructured":"Y. Miao, K. Benwell, T. P. Quinn, 99mTc and 111In labeled \u03b1-melanocyte stimulating hormone peptides as imaging probes for primary and pulmonary metastatic melanoma detection. J. Nucl. Med. 48, 73\u201380 (2007).","journal-title":"J. Nucl. Med."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2007.376.A"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2007.08.001"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm301647t"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc300509k"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc5000115"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.071787"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.086009"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp3006984"},{"key":"e_1_3_1_27_2","first-page":"116","article-title":"A gallium-labeled DOTA-\u03b1-melanocyte-stimulating hormone analog for PET imaging of melanoma metastases","volume":"45","author":"Froidevaux S.","year":"2004","unstructured":"S. Froidevaux, M. Calame-Christe, J. Schuhmacher, H. Tanner, R. Saffrich, M. Henze, A. N. Eberle, A gallium-labeled DOTA-\u03b1-melanocyte-stimulating hormone analog for PET imaging of melanoma metastases. J. Nucl. Med. 45, 116\u2013123 (2004).","journal-title":"J. Nucl. Med."},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.145896"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.979"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2003"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc300191z"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp300246j"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.069"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.08.042"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc900428x"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2010.05.006"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.10.022"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<660::AID-CNCR2820420237>3.0.CO;2-E"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517709101835"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2006.06.005"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10640"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1911-z"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aau4445","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aau4445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:27:55Z","timestamp":1705429675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aau4445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,7]]},"references-count":41,"journal-issue":{"issue":"466","published-print":{"date-parts":[[2018,11,7]]}},"alternative-id":["10.1126\/scitranslmed.aau4445"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aau4445","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,7]]},"article-number":"eaau4445"}}