{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:48:31Z","timestamp":1793256511447,"version":"4.5.0"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"478","funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM007055"],"award-info":[{"award-number":["T32 GM007055"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS083542"],"award-info":[{"award-number":["R01 NS083542"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21 NS101281"],"award-info":[{"award-number":["R21 NS101281"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2019,2,6]]},"abstract":"<jats:p>Sigma-1 receptor is a critical inhibitor of endoplasmic reticulum\u2013driven inflammation and a potential therapeutic target in septic shock.<\/jats:p>","DOI":"10.1126\/scitranslmed.aau5266","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:15:34Z","timestamp":1549498534000},"source":"Crossref","is-referenced-by-count":265,"title":["Modulation of the sigma-1 receptor\u2013IRE1 pathway is beneficial in preclinical models of inflammation and sepsis"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0342-8454","authenticated-orcid":true,"given":"Dorian A.","family":"Rosen","sequence":"first","affiliation":[{"name":"Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA."},{"name":"Graduate Program in Pharmacological Sciences, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Seki","sequence":"additional","affiliation":[{"name":"Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-442X","authenticated-orcid":true,"given":"Anthony","family":"Fern\u00e1ndez-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-6037","authenticated-orcid":true,"given":"Rebecca M.","family":"Beiter","sequence":"additional","affiliation":[{"name":"Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4202-0355","authenticated-orcid":true,"given":"Jacob D.","family":"Eccles","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy and Immunology, Department of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Woodfolk","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy and Immunology, Department of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-6053","authenticated-orcid":true,"given":"Alban","family":"Gaultier","sequence":"additional","affiliation":[{"name":"Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.03.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.183"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1857"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.025"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.664"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00705-15"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.03.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.07.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076941"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2014.12.013"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_15"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.02.004"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1774-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106533"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/157015908787386113"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep18785"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201112098"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115623109"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07661"},{"key":"e_1_3_2_22_2","first-page":"60","article-title":"Acute inflammatory response to endotoxin in mice and humans","volume":"12","author":"Copeland S.","year":"2005","unstructured":"S. Copeland, H. S. Warren, S. F. Lowry, S. E. Calvano, D. Remick, Acute inflammatory response to endotoxin in mice and humans. Clin. Diagn. Lab. Immunol. 12, 60\u201367 (2005).","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.10.010"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385114-7.00004-0"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2016.021"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200206000-00004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-233"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-303099"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04968-z"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/21548331.1991.11707743"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2991"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050454.01978.3B"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00046-1"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2011.09.001"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-6-41"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200508010-00018"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509227103"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.036"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166127"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12430"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8169"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.11.036"},{"key":"e_1_3_2_43_2","first-page":"2033","article-title":"Establishing primary adult fibroblast cultures from rodents","volume":"44","author":"Seluanov A.","year":"2010","unstructured":"A. Seluanov, A. Vaidya, V. Gorbunova, Establishing primary adult fibroblast cultures from rodents. J. Vis. Exp. 44, 2033 (2010).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1401s83"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-127613"},{"key":"e_1_3_2_46_2","first-page":"80","article-title":"Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes","volume":"119","author":"Girard C. A.","year":"2009","unstructured":"C. A. Girard, F. T. Wunderlich, K. Shimomura, S. Collins, S. Kaizik, P. Proks, F. Abdulkader, A. Clark, V. Ball, L. Zubcevic, L. Bentley, R. Clark, C. Church, A. Hugill, J. Galvanovskis, R. Cox, P. Rorsman, J. C. Br\u00fcning, F. M. Ashcroft, Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J. Clin. Invest. 119, 80\u201390 (2009).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.05.018"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600825"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"7.18B.1","DOI":"10.1002\/0471142735.im0718bs66","article-title":"Measurement of cytokine production using whole blood","volume":"66","author":"Thurm C. W.","year":"2005","unstructured":"C. W. Thurm, J. F. Halsey, Measurement of cytokine production using whole blood. Curr. Protoc. Immunol. 66, 7.18B.1\u20137.18B.12 (2005).","journal-title":"Curr. Protoc. Immunol."}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aau5266","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aau5266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T16:04:43Z","timestamp":1720973083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aau5266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,6]]},"references-count":49,"journal-issue":{"issue":"478","published-print":{"date-parts":[[2019,2,6]]}},"alternative-id":["10.1126\/scitranslmed.aau5266"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aau5266","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,6]]},"article-number":"eaau5266"}}