{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:20:19Z","timestamp":1793622019513,"version":"4.5.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"519","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS092597 and DP1NS111132"],"award-info":[{"award-number":["R01NS092597 and DP1NS111132"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex\u2019s Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006352","name":"Virginia and D.K. Ludwig Fund for Cancer Research","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100006352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2019,11,20]]},"abstract":"<jats:p>High-throughput screens in DMG identify promising treatments, such as the combination of panobinostat and marizomib acting through metabolic collapse.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaw0064","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T19:25:01Z","timestamp":1574277901000},"source":"Crossref","is-referenced-by-count":207,"title":["Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-2140","authenticated-orcid":true,"given":"Grant L.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2636-2766","authenticated-orcid":true,"given":"Kelli M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Ceribelli","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-2955","authenticated-orcid":true,"given":"Benjamin Z.","family":"Stanton","sequence":"additional","affiliation":[{"name":"Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamelyn J.","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-381X","authenticated-orcid":true,"given":"Sara","family":"Kreimer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Y.","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lennon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya","family":"Nagaraja","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2380-4178","authenticated-orcid":true,"given":"Patrick J.","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Quezada","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-0860","authenticated-orcid":true,"given":"Shawn M.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-7126","authenticated-orcid":true,"given":"Damien Y.","family":"Duveau","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-6101","authenticated-orcid":true,"given":"Aleksandra M.","family":"Michalowski","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Shinn","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-8819","authenticated-orcid":true,"given":"Rajarshi","family":"Guha","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carleen","family":"Klumpp-Thomas","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-6563","authenticated-orcid":true,"given":"Sam","family":"Michael","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2964-1728","authenticated-orcid":true,"given":"Crystal","family":"McKnight","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paras","family":"Minhas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1686-1326","authenticated-orcid":true,"given":"Zina","family":"Itkin","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-7037","authenticated-orcid":true,"given":"Eric H.","family":"Raabe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-1412","authenticated-orcid":true,"given":"Anna C.","family":"Geraghty","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8391-4155","authenticated-orcid":true,"given":"Katrin I.","family":"Andreasson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3966-4985","authenticated-orcid":true,"given":"Nicholas A.","family":"Vitanza","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Warren","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9386-9001","authenticated-orcid":true,"given":"Craig J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA."},{"name":"Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3547-237X","authenticated-orcid":true,"given":"Michelle","family":"Monje","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160509123229"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2011.06.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox107"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10833"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0998-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1463-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3855"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy059.115"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.03.011"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3716"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4296"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4293"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2284"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.244"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311846111"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524668113"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00029"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200390115"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.10.013"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503221102"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-3068"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov299"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118926"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(84)90007-4"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013984"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24014"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0006-x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2536759100"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.04.001"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0433"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21835"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08342.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.83"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3504"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.039"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep18953"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14498"},{"key":"e_1_3_2_42_2","article-title":"A protocol for rapid post-mortem cell culture of Diffuse Intrinsic Pontine Glioma (DIPG)","volume":"121","author":"Lin G. L.","year":"2017","unstructured":"G. L. Lin, M. Monje, A protocol for rapid post-mortem cell culture of Diffuse Intrinsic Pontine Glioma (DIPG). J. Vis. Exp. 121, 10.3791\/55360, (2017).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604348103"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aaw0064","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaw0064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:03:20Z","timestamp":1705406600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaw0064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":43,"journal-issue":{"issue":"519","published-print":{"date-parts":[[2019,11,20]]}},"alternative-id":["10.1126\/scitranslmed.aaw0064"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaw0064","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,20]]},"article-number":"eaaw0064"}}