{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:19:28Z","timestamp":1792819168591,"version":"4.5.0"},"reference-count":69,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"520","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL094326"],"award-info":[{"award-number":["R01HL094326"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01NS092521"],"award-info":[{"award-number":["P01NS092521"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30NS100252"],"award-info":[{"award-number":["F30NS100252"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2019,11,27]]},"abstract":"<jats:p>Loss of PDCD10 signaling in brain endothelium and gut epithelium contribute to cerebral cavernous malformation in a mouse model.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaw3521","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:14:54Z","timestamp":1574900094000},"source":"Crossref","is-referenced-by-count":74,"title":["Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-0349","authenticated-orcid":true,"given":"Alan T.","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1162-337X","authenticated-orcid":true,"given":"Katie R.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney C.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Goddard","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-5407","authenticated-orcid":true,"given":"Aparna","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1116-900X","authenticated-orcid":true,"given":"Aileen","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidy","family":"Pardo","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-5563","authenticated-orcid":true,"given":"Amy","family":"Peiper","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-4833","authenticated-orcid":true,"given":"Erin","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceylan","family":"Tanes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Mattei","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mericko-Ishizuka","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-5476","authenticated-orcid":true,"given":"Le","family":"Shen","sequence":"additional","affiliation":[{"name":"Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6034-8795","authenticated-orcid":true,"given":"Nicholas","family":"Hobson","sequence":"additional","affiliation":[{"name":"Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-9315","authenticated-orcid":true,"given":"Romuald","family":"Girard","sequence":"additional","affiliation":[{"name":"Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Lightle","sequence":"additional","affiliation":[{"name":"Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Moore","sequence":"additional","affiliation":[{"name":"Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-6845","authenticated-orcid":true,"given":"Robert","family":"Shenkar","sequence":"additional","affiliation":[{"name":"Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Polster","sequence":"additional","affiliation":[{"name":"Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-1537","authenticated-orcid":true,"given":"Claudia J.","family":"R\u00f6del","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5539-6071","authenticated-orcid":true,"given":"Qin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-7309","authenticated-orcid":true,"given":"Kevin J.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6277-5168","authenticated-orcid":true,"given":"Xiangjian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China."},{"name":"Centenary Institute, Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Akers","sequence":"additional","affiliation":[{"name":"Angioma Alliance, Norfolk, VA 23517, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-193X","authenticated-orcid":true,"given":"Leslie","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Neurology and Pediatrics, University of New Mexico, Albuquerque, NM 87106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-354X","authenticated-orcid":true,"given":"Helen","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Bittinger","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-5189","authenticated-orcid":true,"given":"Christopher J.","family":"Lengner","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-9718","authenticated-orcid":true,"given":"Markus","family":"Schwaninger","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology, University of L\u00fcbeck, 23562 L\u00fcbeck, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Velcich","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Albert Einstein College of Medicine\/Albert Einstein Cancer Center, NY 10461, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-5489","authenticated-orcid":true,"given":"Leonard","family":"Augenlicht","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Albert Einstein College of Medicine\/Albert Einstein Cancer Center, NY 10461, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-3841","authenticated-orcid":true,"given":"Salim","family":"Abdelilah-Seyfried","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany."},{"name":"Institute of Molecular Biology, Hannover Medical School, Carl-Neuberg Str. 1, D-30625 Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Marchuk","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issam A.","family":"Awad","sequence":"additional","affiliation":[{"name":"Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-7086","authenticated-orcid":true,"given":"Mark L.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4068"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4194"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0059-z"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.018"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06852"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18309"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.10.016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4476"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.100"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000486292"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx091"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17178"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8937"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2015.04.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510495112"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.12.009"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20947"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.97"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22075"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn430"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi256"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110398"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505433"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.12.016"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"e0160833","DOI":"10.1371\/journal.pone.0160833","article-title":"Micro-CT imaging reveals Mekk3 heterozygosity prevents cerebral cavernous malformations in Ccm2-deficient mice","volume":"11","author":"Choi J. P.","year":"2016","unstructured":"J. P. Choi, M. Foley, Z. Zhou, W.-Y. Wong, N. Gokoolparsadh, J. S. Arthur, D. Y. Li, X. Zheng, Micro-CT imaging reveals Mekk3 heterozygosity prevents cerebral cavernous malformations in Ccm2-deficient mice. PLOS ONE 11, e0160833 (2016).","journal-title":"PLOS ONE"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2016.06.021"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208344"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25973"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-018-0030-y"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803124105"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012238"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006451107"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044328"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000902"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7419"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.04.020"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014325"},{"key":"e_1_3_2_40_2","first-page":"701","article-title":"Cerebral cavernous malformation proteins at a glance","volume":"127","author":"Draheim K. M.","year":"2014","unstructured":"K. M. Draheim, O. S. Fisher, T. J. Boggon, D. A. Calderwood, Cerebral cavernous malformation proteins at a glance. J. Cell Sci. 127, 701\u2013707 (2014).","journal-title":"J. Cell Sci."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109051"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201439263"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.07.011"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14232"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88886"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210200110"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108126"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121268"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006-60.1.25"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800266-MCP200"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.09.021"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4169"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.02.028"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.625467"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015013"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09002"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu342"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.06.004"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069094"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204935200"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63067"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098186"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308335110"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11992"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.139"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst010"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009490"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8228-8235.2005"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01996-06"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aaw3521","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaw3521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:20:47Z","timestamp":1705429247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaw3521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,27]]},"references-count":69,"journal-issue":{"issue":"520","published-print":{"date-parts":[[2019,11,27]]}},"alternative-id":["10.1126\/scitranslmed.aaw3521"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaw3521","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,27]]},"article-number":"eaaw3521"}}