{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:11:23Z","timestamp":1790802683984,"version":"4.1.0"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"519","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR007107-41"],"award-info":[{"award-number":["AR007107-41"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201100019C"],"award-info":[{"award-number":["HHSN272201100019C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR40072"],"award-info":[{"award-number":["AR40072"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI071087"],"award-info":[{"award-number":["AI071087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000938","name":"Robert E. Leet and Clara Guthrie Patterson Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000938","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2019,11,20]]},"abstract":"<jats:p>Defective ATM activation skews the B cell repertoire and increases RANKL production, promoting joint erosion in patients with rheumatoid arthritis.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaw4626","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:25:01Z","timestamp":1574295901000},"source":"Crossref","is-referenced-by-count":29,"title":["Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-4707","authenticated-orcid":true,"given":"Kofi A.","family":"Mensah","sequence":"first","affiliation":[{"name":"Section of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA."},{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-7820","authenticated-orcid":true,"given":"Jeff W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Nicolas","family":"Schickel","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Isnardi","sequence":"additional","affiliation":[{"name":"Novartis Institute for Biomedical Research, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-9527","authenticated-orcid":true,"given":"Natsuko","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vega-Loza","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Anolik","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Gatti","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin W.","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Health, University of Colorado, Denver, CO 80113, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-4454","authenticated-orcid":true,"given":"Ruth R.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1368-6756","authenticated-orcid":true,"given":"Joe E.","family":"Craft","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA."},{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-0171","authenticated-orcid":true,"given":"Eric","family":"Meffre","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06511, USA."},{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"S295","article-title":"Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis","volume":"18","author":"Gibofsky A.","year":"2012","unstructured":"A. Gibofsky, Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Am. J. Manag. Care 18, S295\u2013S302 (2012).","journal-title":"Am. J. Manag. Care"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032534"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20316"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042321"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-009-8093-x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-037994"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.06.011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3422"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-0957-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39489"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.153312"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2010.03.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-243071"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901984106"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37828"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.08.015"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331462"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.028"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.8.4180"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-456897"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04866"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2941"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1735"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121605"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082251"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.013"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406879200"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086907"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.4.1001"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00935.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5858"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0543-7"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.053"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2017.09.031"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2750::AID-ART462>3.0.CO;2-C"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31472-1"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.031"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2727"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39837"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl116"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6477"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaf7153"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7886"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05877.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060964"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140457"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092210"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.11.002"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad7151"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60975"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1279"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12873"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep34426"},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.4049\/jimmunol.161.11.6113","article-title":"OPG\/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40","volume":"161","author":"Yun T. J.","year":"1998","unstructured":"T. J. Yun, P. M. Chaudhary, G. L. Shu, J. K. Frazer, M. K. Ewings, S. M. Schwartz, V. Pascual, L. E. Hood, E. A. Clark, OPG\/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. J. Immunol. 161, 6113\u20136121 (1998).","journal-title":"J. Immunol."},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.03.004"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.84610"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600522"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2620"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0976"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/em.20273"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aaw4626","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaw4626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:03:29Z","timestamp":1705424609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaw4626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":62,"journal-issue":{"issue":"519","published-print":{"date-parts":[[2019,11,20]]}},"alternative-id":["10.1126\/scitranslmed.aaw4626"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaw4626","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,20]]},"article-number":"eaaw4626"}}