{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:51:01Z","timestamp":1791985861154,"version":"4.4.0"},"reference-count":44,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"522","funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH110610"],"award-info":[{"award-number":["MH110610"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH115668"],"award-info":[{"award-number":["MH115668"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MG105839"],"award-info":[{"award-number":["MG105839"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA042012"],"award-info":[{"award-number":["DA042012"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2019,12,11]]},"abstract":"<jats:p>MDMA, which has both therapeutic and abuse potential, engages a brain region\u2013specific serotonergic pathway to produce its prosocial effect.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaw6435","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T19:15:41Z","timestamp":1576091741000},"source":"Crossref","is-referenced-by-count":117,"title":["Distinct neural mechanisms for the prosocial and rewarding properties of MDMA"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1474-0379","authenticated-orcid":true,"given":"Boris D.","family":"Heifets","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-846X","authenticated-orcid":true,"given":"Juliana S.","family":"Salgado","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA."},{"name":"Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8092-3029","authenticated-orcid":true,"given":"Madison D.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-5376","authenticated-orcid":true,"given":"Paul","family":"Hoerbelt","sequence":"additional","affiliation":[{"name":"Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-4643","authenticated-orcid":true,"given":"Daniel F.","family":"Cardozo Pinto","sequence":"additional","affiliation":[{"name":"Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Y.","family":"Sze","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Rose F. Kennedy Intellectual and Developmental Disabilities Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-5211","authenticated-orcid":true,"given":"Robert C.","family":"Malenka","sequence":"additional","affiliation":[{"name":"Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"U. D. McCann G. A. Ricaurte in The Effects of Drug Abuse on the Human Nervous System B. Madras M. Kuhar Eds. (Elsevier Inc. 2013) pp. 475\u2013497.","DOI":"10.1016\/B978-0-12-418679-8.00015-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.1986.10472364"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.08.016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4779-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-5010-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.3.3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00234-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.04.005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.110"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328333a28d"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043107"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hup.348"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.75"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.11.005"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0416-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1848.2004.00076.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050038"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0072-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.5.1817"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66010243.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2174\/157015911795017254"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6250-10.2011"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300476"},{"key":"e_1_3_2_26_2","first-page":"820","article-title":"Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: Effect of dopamine uptake inhibitors","volume":"259","author":"Nash J. F.","year":"1991","unstructured":"J. F. Nash, J. Brodkin, Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: Effect of dopamine uptake inhibitors. J. Pharmacol. Exp. Ther. 259, 820\u2013825 (1991).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4778-04.2005"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.015"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170934"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1075-9"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4994"},{"key":"e_1_3_2_32_2","unstructured":"S. Garattini R. Samanin Central Mechanisms of Anorectic Drugs (Monographs of the Mario Negri Institute for Pharmacological Research Raven Press 1978)."},{"key":"e_1_3_2_33_2","unstructured":"https:\/\/clinicaltrials.gov\/ct2\/results?term=fenfluramine&cntry=US."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1975185part1563"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198907000-00014"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60252-X"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105048900"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.138"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11160"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253994"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.017"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.12.033"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2707-07.2007"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1710"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0224-12.2012"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aaw6435","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaw6435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:08:08Z","timestamp":1705406888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaw6435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":44,"journal-issue":{"issue":"522","published-print":{"date-parts":[[2019,12,11]]}},"alternative-id":["10.1126\/scitranslmed.aaw6435"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaw6435","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/659466","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]},"article-number":"eaaw6435"}}