{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T03:51:43Z","timestamp":1775965903148,"version":"3.50.1"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"521","funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1139927"],"award-info":[{"award-number":["OPP1139927"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2019,12,4]]},"abstract":"<jats:p>An oral dosage form that resides in the stomach releases the contraceptive levonorgestrel over 1 month in pigs.<\/jats:p>","DOI":"10.1126\/scitranslmed.aay2602","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:17:37Z","timestamp":1575505057000},"source":"Crossref","is-referenced-by-count":44,"title":["A once-a-month oral contraceptive"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3779-0363","authenticated-orcid":true,"given":"Ameya R.","family":"Kirtane","sequence":"first","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Hua","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-8563","authenticated-orcid":true,"given":"Alison","family":"Hayward","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambika","family":"Bajpayee","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Mechanical Engineering, Northeastern University, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniket","family":"Wahane","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Lopes","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Bensel","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank Z.","family":"Stanczyk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sierra","family":"Brooks","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan","family":"Gwynne","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Wainer","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-4517","authenticated-orcid":true,"given":"Joy","family":"Collins","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7909-3294","authenticated-orcid":true,"given":"Siddartha M.","family":"Tamang","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4255-0492","authenticated-orcid":true,"given":"Robert","family":"Langer","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-4077","authenticated-orcid":true,"given":"Giovanni","family":"Traverso","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization \u201cFamily planning\/contraception \u201d (2018); www.who.int\/news-room\/fact-sheets\/detail\/family-planning-contraception."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.07.013"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121280"},{"key":"e_1_3_2_5_2","unstructured":"Centers Disease Control and Prevention \u201cContraception \u201d (2018); www.cdc.gov\/reproductivehealth\/contraception\/index.htm."},{"key":"e_1_3_2_6_2","unstructured":"United States Food and Drug Administration Nexplanon FDA label (2015); www.accessdata.fda.gov\/drugsatfda_docs\/label\/2015\/021529s011lbl.pdf."},{"key":"e_1_3_2_7_2","unstructured":"United States Food and Drug Administration Implanon information leaflet (2008); www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/021529s004lbl.pdf."},{"key":"e_1_3_2_8_2","unstructured":"United States Food Drug and Administration Mirena FDA label (2015); www.accessdata.fda.gov\/drugsatfda_docs\/label\/2015\/021225s031lbl.pdf)."},{"key":"e_1_3_2_9_2","unstructured":"United States Food Drug and Administration Liletta FDA label (2018); www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/206229s007lbl.pdf)."},{"key":"e_1_3_2_10_2","unstructured":"United States Food and Drug Administration Kyleena FDA label (2016); www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2016\/208224Orig1s000LBL.pdf."},{"key":"e_1_3_2_11_2","unstructured":"United States Food and Drug Administration Skyla FDA label (2017); www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/203159s007lbl.pdf."},{"key":"e_1_3_2_12_2","unstructured":"United States Food and Drug Administration Depo-Provera FDA label (2010); www.accessdata.fda.gov\/drugsatfda_docs\/label\/2010\/020246s036lbl.pdf."},{"key":"e_1_3_2_13_2","unstructured":"United States Food and Drug Administration Nuva Ring FDA label (2013); www.accessdata.fda.gov\/drugsatfda_docs\/label\/2013\/021187s022lbl.pdf."},{"key":"e_1_3_2_14_2","unstructured":"United States Food and Drug Administration Ortho Evra FDA label (2014); www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/021180Orig1s046lbl.pdf."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-015-1686-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0337-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00010-7"},{"key":"e_1_3_2_18_2","first-page":"574329","article-title":"Predictors of contraceptive adherence among women seeking family planning services at reproductive health Uganda, Mityana branch","volume":"2015","author":"Muhindo R.","year":"2015","unstructured":"R. Muhindo, J. N. Okonya, S. Groves, M. Chenault, Predictors of contraceptive adherence among women seeking family planning services at reproductive health Uganda, Mityana branch. Int. J. Popul. Res. 2015, 574329 (2015).","journal-title":"Int. J. Popul. Res."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2015181"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2165\/11538900-000000000-00000"},{"key":"e_1_3_2_21_2","unstructured":"R. Hatcher Contraceptive Technology D. Kowal R. A. Hatcher A. L. Nelson J. Trussell C. Cwiak P. Cason M. S. Policar A. B. Edelman A. R. A. Aiken J. M. Marrazzo Eds. (Managing Contraception LLC ed. 21 2018)."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.05.505"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-015-0231-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02294-6"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30212-3"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag2374"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(72)90036-0"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(02)00321-9"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00144-z"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau8581"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.09.015"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/admt.201800490"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aay2602","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aay2602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:08:50Z","timestamp":1705424930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aay2602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,4]]},"references-count":31,"journal-issue":{"issue":"521","published-print":{"date-parts":[[2019,12,4]]}},"alternative-id":["10.1126\/scitranslmed.aay2602"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aay2602","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,4]]},"article-number":"eaay2602"}}