{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:32:31Z","timestamp":1791415951662,"version":"4.3.3"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"523","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P510D11107"],"award-info":[{"award-number":["P510D11107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA009111"],"award-info":[{"award-number":["T32 CA009111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI129479-S"],"award-info":[{"award-number":["R21AI129479-S"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS104692"],"award-info":[{"award-number":["R21NS104692"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD090856"],"award-info":[{"award-number":["R21HD090856"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD098389"],"award-info":[{"award-number":["R01 HD098389"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:p>A Zika virus vaccine administered to macaques before conception reduces maternal viremia and improves fetal outcomes.<\/jats:p>","DOI":"10.1126\/scitranslmed.aay2736","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:07:02Z","timestamp":1576714022000},"source":"Crossref","is-referenced-by-count":45,"title":["DNA vaccination before conception protects Zika virus\u2013exposed pregnant macaques against prolonged viremia and improves fetal outcomes"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7375-1337","authenticated-orcid":true,"given":"Koen K. A.","family":"Van Rompay","sequence":"first","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."},{"name":"Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah I.","family":"Keesler","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-4659","authenticated-orcid":true,"given":"Amir","family":"Ardeshir","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Watanabe","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Usachenko","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Singapuri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-8417","authenticated-orcid":true,"given":"Christina","family":"Cruzen","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-5612","authenticated-orcid":true,"given":"Eliza","family":"Bliss-Moreau","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."},{"name":"Department of Psychology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4544-8207","authenticated-orcid":true,"given":"Ashley M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."},{"name":"Department of Psychology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn L.","family":"Yee","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Webster","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-2635","authenticated-orcid":true,"given":"Maria","family":"Dennis","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-7861","authenticated-orcid":true,"given":"Tulika","family":"Singh","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Heimsath","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Lemos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-1737","authenticated-orcid":true,"given":"Jackson","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-4690","authenticated-orcid":true,"given":"Kaitlyn M.","family":"Morabito","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryant M.","family":"Foreman","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-2467","authenticated-orcid":true,"given":"Katherine E.","family":"Burgomaster","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-1933","authenticated-orcid":true,"given":"Amy T.","family":"Noe","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3641-6852","authenticated-orcid":true,"given":"Kimberly A.","family":"Dowd","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-6612","authenticated-orcid":true,"given":"Erin","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3588-9359","authenticated-orcid":true,"given":"Kevin","family":"Woolard","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-1814","authenticated-orcid":true,"given":"Pietro","family":"Presicce","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhas G.","family":"Kallapur","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1438-4554","authenticated-orcid":true,"given":"Sallie R.","family":"Permar","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-6495","authenticated-orcid":true,"given":"Kathryn E.","family":"Foulds","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-5146","authenticated-orcid":true,"given":"Lark L.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-4348","authenticated-orcid":true,"given":"Theodore C.","family":"Pierson","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8112-0853","authenticated-orcid":true,"given":"Barney S.","family":"Graham","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00072-15"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002203"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.357.6352.631"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0088-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04777-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.019"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4193"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02499-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4485"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006378"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0039-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai9137"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33105-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-018-0061-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.361.6407.1055"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.12.040"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709481"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12204"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005168"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1601824"},{"key":"e_1_3_2_24_2","first-page":"162","article-title":"Left ventricular hypertrophy in rhesus macaques (Macaca mulatta) at the California National Primate Research Center (1992-2014)","volume":"66","author":"Reader J. R.","year":"2016","unstructured":"J. R. Reader, D. R. Canfield, J. F. Lane, S. Kanthaswamy, A. Ardeshir, A. M. Allen, R. P. Tarara, Left ventricular hypertrophy in rhesus macaques (Macaca mulatta) at the California National Primate Research Center (1992-2014). Comp. Med. 66, 162\u2013169 (2016).","journal-title":"Comp. Med."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171148"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv044"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao4163"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.9.4040-4047.2001"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511526112"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006524"},{"key":"e_1_3_2_31_2","unstructured":"A. F. Tarantal in The Laboratory Primate S. Wolfe-Coote Ed. (Elsevier 2005) pp. 317\u2013352."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bdq.2017.04.001"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7120496"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.049"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.08.009"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22008"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aay2736","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aay2736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:22:06Z","timestamp":1705425726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aay2736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":35,"journal-issue":{"issue":"523","published-print":{"date-parts":[[2019,12,18]]}},"alternative-id":["10.1126\/scitranslmed.aay2736"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aay2736","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]},"article-number":"eaay2736"}}