{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:47:19Z","timestamp":1792180039315,"version":"4.4.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"570","funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI101018"],"award-info":[{"award-number":["R01 AI101018"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DP1 DK113598"],"award-info":[{"award-number":["DP1 DK113598"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK110174"],"award-info":[{"award-number":["R01 DK110174"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000064","name":"National Center for Complementary and Alternative Medicine","doi-asserted-by":"publisher","award":["U41 AT008718"],"award-info":[{"award-number":["U41 AT008718"]}],"id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2016-03962"],"award-info":[{"award-number":["RGPIN-2016-03962"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2020,11,18]]},"abstract":"<jats:p>\n                    Cutimycin, a thiopeptide antibiotic produced by the skin commensal\n                    <jats:italic>Cutibacterium acnes<\/jats:italic>\n                    , reduces\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    colonization of human skin hair follicles.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aay5445","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T19:23:47Z","timestamp":1605727427000},"source":"Crossref","is-referenced-by-count":171,"title":["A\n                    <i>Cutibacterium acnes<\/i>\n                    antibiotic modulates human skin microbiota composition in hair follicles"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-7974","authenticated-orcid":true,"given":"Jan","family":"Claesen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B.","family":"Spagnolo","sequence":"additional","affiliation":[{"name":"Microbiology, Forsyth Institute, Cambridge, MA 02142, USA."},{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1918-9769","authenticated-orcid":true,"given":"Stephany Flores","family":"Ramos","sequence":"additional","affiliation":[{"name":"Microbiology, Forsyth Institute, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-7033","authenticated-orcid":true,"given":"Kenji L.","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-3621","authenticated-orcid":true,"given":"Allyson L.","family":"Byrd","sequence":"additional","affiliation":[{"name":"Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9445-2248","authenticated-orcid":true,"given":"Alexander A.","family":"Aksenov","sequence":"additional","affiliation":[{"name":"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-8880","authenticated-orcid":true,"given":"Alexey V.","family":"Melnik","sequence":"additional","affiliation":[{"name":"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-7344","authenticated-orcid":true,"given":"Weng R.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8111-2850","authenticated-orcid":true,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-504X","authenticated-orcid":true,"given":"Ryan D.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Human Genetics, McGill University and Genome Quebec Innovation Center, Montreal, QC H3A 0C7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-2912","authenticated-orcid":true,"given":"Mohamed S.","family":"Donia","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-1030","authenticated-orcid":true,"given":"Pieter C.","family":"Dorrestein","sequence":"additional","affiliation":[{"name":"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-064X","authenticated-orcid":true,"given":"Heidi H.","family":"Kong","sequence":"additional","affiliation":[{"name":"Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6860-348X","authenticated-orcid":true,"given":"Julia A.","family":"Segre","sequence":"additional","affiliation":[{"name":"Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-4971","authenticated-orcid":true,"given":"Roger G.","family":"Linington","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-8247","authenticated-orcid":true,"given":"Michael A.","family":"Fischbach","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-1679","authenticated-orcid":true,"given":"Katherine P.","family":"Lemon","sequence":"additional","affiliation":[{"name":"Microbiology, Forsyth Institute, Cambridge, MA 02142, USA."},{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."},{"name":"Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology &amp; Microbiology, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Section of Infectious Diseases, Department of Pediatrics, Texas Children\u2019s Hospital and Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25177"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.157"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.001367"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08437.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.034"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.08.032"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18634"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah4680"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09074"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.11.001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01230"},{"key":"e_1_3_2_13_2","article-title":"Competition among nasal bacteria suggests a role for siderophore-mediated interactions in shaping the human nasal microbiota","author":"Stubbendieck R. M.","year":"2018","unstructured":"R. M. Stubbendieck, D. S. May, M. G. Chevrette, M. I. Temkin, E. Wendt-Pienkowski, J. Cagnazzo, C. M. Carlson, J. E. Gern, C. R. Currie, Competition among nasal bacteria suggests a role for siderophore-mediated interactions in shaping the human nasal microbiota. Appl. Environ. Microbiol. , (2018).","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01725-15"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1586\/edm.10.6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005812"},{"key":"e_1_3_2_17_2","first-page":"fiy241","article-title":"Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens","volume":"95","author":"O\u2019Sullivan J. N.","year":"2018","unstructured":"J. N. O\u2019Sullivan, M. C. Rea, P. M. O\u2019Connor, C. Hill, R. P. Ross, Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens. FEMS Microbiol. Ecol. 95, fiy241 (2018).","journal-title":"FEMS Microbiol. Ecol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06305-11"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04251-14"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021581"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900008106"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)80308-1"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.47.1466"},{"key":"e_1_3_2_24_2","unstructured":"M. E. Bergy J. H. Coats F. Reusser Antibiotic berninamycin and process for making same U.S. Patent 3 689 639A (1972)."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307111110"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100330"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b01381"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2003.22110.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.008"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00187-18"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440102"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.110"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0558-5"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055380"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12260695"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1318"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90297-O"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","unstructured":"L. Eggeling M. Bott Handbook of Corynebacterium Glutamicum (Taylor & Francis 2005) p. 616.","DOI":"10.1201\/9781420039696"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0646-9"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr509"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.038"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aay5445","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aay5445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:20:55Z","timestamp":1705411255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aay5445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":42,"journal-issue":{"issue":"570","published-print":{"date-parts":[[2020,11,18]]}},"alternative-id":["10.1126\/scitranslmed.aay5445"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aay5445","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/594010","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]},"article-number":"eaay5445"}}