{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:36:15Z","timestamp":1793763375866,"version":"4.6.1"},"reference-count":70,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"547","funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["BC151845"],"award-info":[{"award-number":["BC151845"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21 CA207816"],"award-info":[{"award-number":["R21 CA207816"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R33 CA214333"],"award-info":[{"award-number":["R33 CA214333"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA191785"],"award-info":[{"award-number":["R01 CA191785"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA243445"],"award-info":[{"award-number":["R01CA243445"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R21 EB024101"],"award-info":[{"award-number":["R21 EB024101"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2020,6,10]]},"abstract":"<jats:p>An inkjet-printed nanochip integrating multiparametric extracellular vesicle analyses monitors tumor burden via liquid biopsy.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaz2878","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T19:19:18Z","timestamp":1591816758000},"source":"Crossref","is-referenced-by-count":147,"title":["Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0896-6411","authenticated-orcid":true,"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-4107","authenticated-orcid":true,"given":"Xiaoqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-1893","authenticated-orcid":true,"given":"Gulhumay","family":"Gardashova","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-0998","authenticated-orcid":true,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bioengineering Graduate Program, University of Kansas, Lawrence, KS 66045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9196-4232","authenticated-orcid":true,"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA."},{"name":"Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS 66160, USA."},{"name":"University of Kansas Cancer Center, Kansas City, KS 66160, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-109X","authenticated-orcid":true,"given":"Yong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA."},{"name":"Bioengineering Graduate Program, University of Kansas, Lawrence, KS 66045, USA."},{"name":"University of Kansas Cancer Center, Kansas City, KS 66160, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203543"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14347"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.166"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12625"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.123"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213261"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.14"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3402"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0036-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.029"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.04.006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.024"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3169"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2753"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15756"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006500406240"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64887-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21923"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00534"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC00961B"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0356-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2018.09.121"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02261-1"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2994"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201503339"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b11409"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2006.01.031"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-015-1065-2"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201404559"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8NA00328A"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6LC00279J"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521230113"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.03.004"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-09-0523"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-188"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3255"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135544"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn180"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-44"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.050"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201600370"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.10.007"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140510015"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12930-y"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3ib20196a"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910962106"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/laban.254"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal3226"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0343-6"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b05503"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2014.261"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.03.017"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201602736"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/mi8090274"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2177"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.05.044"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.4161\/21541248.2014.985484"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7919"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10794-w"},{"key":"e_1_3_2_63_2","unstructured":"N. Howlader A. M. Noone M. Krapcho D. Miller A. Brest M. Yu J. Ruhl Z. Tatalovich A. Mariotto D. R. Lewis H. S. Chen E. J. Feuer K. A. Cronin SEER Cancer Statistics Review 1975\u20132016 . National Cancer Institute. Bethesda MD https:\/\/seer.cancer.gov\/csr\/1975_2016\/ based on November 2018 SEER data submission posted to the SEER web site April 2019."},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61611-0"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.141"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0931261100"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.03.012"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1501645"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1709210114"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3lc50783a"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4LC00662C"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aaz2878","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaz2878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:45:07Z","timestamp":1705409107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaz2878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":70,"journal-issue":{"issue":"547","published-print":{"date-parts":[[2020,6,10]]}},"alternative-id":["10.1126\/scitranslmed.aaz2878"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaz2878","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]},"article-number":"eaaz2878"}}