{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:00:55Z","timestamp":1772697655914,"version":"3.50.1"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"606","funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["Health Protection Research Unit in Immunisation"],"award-info":[{"award-number":["Health Protection Research Unit in Immunisation"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Trust and Royal Society","award":["208812\/Z\/17\/Z"],"award-info":[{"award-number":["208812\/Z\/17\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,8,11]]},"abstract":"<jats:p>Microbial competition and diversity may influence selection for antibiotic-resistant bacteria after vaccination.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaz8690","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T19:15:17Z","timestamp":1628709317000},"source":"Crossref","is-referenced-by-count":20,"title":["Modeling the effect of vaccination on selection for antibiotic resistance in\n            <i>Streptococcus pneumonia<\/i>\n            <i>e<\/i>"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-1412","authenticated-orcid":true,"given":"Nicholas G.","family":"Davies","sequence":"first","affiliation":[{"name":"Centre for Mathematical Modelling of Infectious Diseases; Vaccine Centre; and Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5808-2606","authenticated-orcid":true,"given":"Stefan","family":"Flasche","sequence":"additional","affiliation":[{"name":"Centre for Mathematical Modelling of Infectious Diseases; Vaccine Centre; and Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-8255","authenticated-orcid":true,"given":"Mark","family":"Jit","sequence":"additional","affiliation":[{"name":"Centre for Mathematical Modelling of Infectious Diseases; Vaccine Centre; and Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-0558","authenticated-orcid":true,"given":"Katherine E.","family":"Atkins","sequence":"additional","affiliation":[{"name":"Centre for Mathematical Modelling of Infectious Diseases; Vaccine Centre; and Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK."},{"name":"Centre for Global Health, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"J. O\u2019Neill Vaccines and alternative approaches: Reducing our dependence on antimicrobials (2016); http:\/\/amr-review.org\/sites\/default\/files\/Vaccines and alternatives_v4_LR.pdf."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00428-16"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30328-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717161115"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721095115"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051642"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1004-z"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30422-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.08.031"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2010.03.005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001017"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30660-1"},{"key":"e_1_3_2_14_2","unstructured":"European Centre for Disease Prevention and Control Antimicrobial consumption rates by country (2018); http:\/\/ecdc.europa.eu\/en\/healthtopics\/antimicrobial_resistance\/esac-net-database\/Pages\/Antimicrobial-consumption-rates-by-country.aspx."},{"key":"e_1_3_2_15_2","unstructured":"World Health Organization WHO vaccine pipeline tracker (2019); www.who.int\/immunization\/research\/vaccine_pipeline_tracker_spreadsheet\/en\/."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2017.0620"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30478-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30043-3"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2206-2213.2004"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268804003565"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002089"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.03.030"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep11293"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0342"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718712115"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2009.0400"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-018-0786-x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17907-0"},{"key":"e_1_3_2_29_2","unstructured":"European Centre for Disease Prevention and Control Data from the ECDC Surveillance Atlas - Antimicrobial resistance (2016); https:\/\/ecdc.europa.eu\/en\/antimicrobial-resistance\/surveillance-and-disease-data\/data-ecdc."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2008.07.001"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tpb.2006.10.004"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059529"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182005009790"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2011.04.011"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2018.0040"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008010"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003134"},{"key":"e_1_3_2_38_2","first-page":"477","article-title":"Evolution of antibiotic resistance by human and bacterial niche construction","volume":"59","author":"Boni M. F.","year":"2006","unstructured":"M. F. Boni, M. W. Feldman, Evolution of antibiotic resistance by human and bacterial niche construction. Evolution 59, 477\u2013491 (2006).","journal-title":"Evolution"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617849114"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.1152"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11538-016-0201-1"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100458"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16357-5"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy219"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.07.002"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2319"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810840115"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01913-06"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268804001980"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215947"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121383109"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006665"},{"key":"e_1_3_2_53_2","unstructured":"UK Department of Health and Social Care Tackling antimicrobial resistance 2019 to 2024: The UK\u2019s 5-year national action plan (2019); www.gov.uk\/government\/publications\/uk-5-year-action-plan-for-antimicrobial-resistance-2019-to-2024."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.06.030"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401914"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30605-4"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-2103-0"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31824f2f32"},{"key":"e_1_3_2_59_2","first-page":"010401","article-title":"Epidemiology and etiology of childhood pneumonia in 2010: Estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries","volume":"3","author":"Rudan I.","year":"2013","unstructured":"I. Rudan, K. L. O\u2019Brien, H. Nair, L. Liu, E. Theodoratou, S. Qazi, I. Luksic, C. L. F. Walker, R. E. Black, H. Campbell; Child Health Epidemiology Reference Group, Epidemiology and etiology of childhood pneumonia in 2010: Estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries. J. Glob. Health 3, 010401 (2013).","journal-title":"J. Glob. Health"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.04.066"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1147-x"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.53"},{"key":"e_1_3_2_63_2","unstructured":"S. Flasche A. Guilder Using a mathematical model to assess the potential effects of a new vaccine approach that targets enhanced clearance of pneumococcal carriage. (2018)."},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2485-2491.2000"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707766104"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715874115"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy343"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007763"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2005.09.009"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-012-0302-1"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4905-4"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268812001057"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2017.0295"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000519"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-006-6618-y"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11222-006-8769-1"},{"key":"e_1_3_2_77_2","unstructured":"Eurostat (2019); https:\/\/ec.europa.eu\/eurostat\/home?."},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx500"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aaz8690","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaz8690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:45:28Z","timestamp":1705427128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaz8690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":77,"journal-issue":{"issue":"606","published-print":{"date-parts":[[2021,8,11]]}},"alternative-id":["10.1126\/scitranslmed.aaz8690"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaz8690","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]},"article-number":"eaaz8690"}}