{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:54:15Z","timestamp":1793771655960,"version":"4.6.1"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"592","funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR066124"],"award-info":[{"award-number":["R01 AR066124"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["GA17-09525S"],"award-info":[{"award-number":["GA17-09525S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["GA19-20123S"],"award-info":[{"award-number":["GA19-20123S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["LQ1605"],"award-info":[{"award-number":["LQ1605"]}],"id":[{"id":"https:\/\/ror.org\/037n8p820","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["LQ1601"],"award-info":[{"award-number":["LQ1601"]}],"id":[{"id":"https:\/\/ror.org\/037n8p820","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["LTAUSA19030"],"award-info":[{"award-number":["LTAUSA19030"]}],"id":[{"id":"https:\/\/ror.org\/037n8p820","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["CZ.02.1.01\/0.0\/0.0\/15_003\/0000460"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/15_003\/0000460"]}],"id":[{"id":"https:\/\/ror.org\/037n8p820","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"the Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["20ek0109323h003"],"award-info":[{"award-number":["20ek0109323h003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agency for Healthcare Research of the Czech Republic","award":["NV18-08-00567"],"award-info":[{"award-number":["NV18-08-00567"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:p>We report reversal of the FGFR3-related skeletal dysplasia by RNA aptamer designed to neutralize FGFR3 ligand FGF2.<\/jats:p>","DOI":"10.1126\/scitranslmed.aba4226","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T15:13:25Z","timestamp":1620227605000},"source":"Crossref","is-referenced-by-count":48,"title":["An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-8903","authenticated-orcid":true,"given":"Takeshi","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-0344","authenticated-orcid":true,"given":"Michaela","family":"Bosakova","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic."},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 65691 Brno, Czech Republic."},{"name":"Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 60200 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-2800","authenticated-orcid":true,"given":"Yosuke","family":"Nonaka","sequence":"additional","affiliation":[{"name":"RIBOMIC Inc., Tokyo 108-0071, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0651-059X","authenticated-orcid":true,"given":"Eva","family":"Hruba","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 60200 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0428-5272","authenticated-orcid":true,"given":"Kie","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-1528","authenticated-orcid":true,"given":"Satoshi","family":"Futakawa","sequence":"additional","affiliation":[{"name":"RIBOMIC Inc., Tokyo 108-0071, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-4405","authenticated-orcid":true,"given":"Takuo","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-7937","authenticated-orcid":true,"given":"Bohumil","family":"Fafilek","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic."},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 65691 Brno, Czech Republic."},{"name":"Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 60200 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-1316","authenticated-orcid":true,"given":"Tomas","family":"Gregor","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic."},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 65691 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara P.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-6507","authenticated-orcid":true,"given":"Regina","family":"Gomolkova","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic."},{"name":"Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 60200 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0539-0194","authenticated-orcid":true,"given":"Silvie","family":"Belaskova","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 65691 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-1005","authenticated-orcid":true,"given":"Martin","family":"Pesl","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic."},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 65691 Brno, Czech Republic."},{"name":"First Department of Internal Medicine-Cardioangiology, St. Anne\u2019s University Hospital, Masaryk University, 65691 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Csukasi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN)-LABRET, University of M\u00e1laga, IBIMA-BIONAND, 29071 M\u00e1laga, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Duran","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN)-LABRET, University of M\u00e1laga, IBIMA-BIONAND, 29071 M\u00e1laga, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-5645","authenticated-orcid":true,"given":"Masatoshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"RIBOMIC Inc., Tokyo 108-0071, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-9292","authenticated-orcid":true,"given":"Michaela","family":"Kavkova","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, Brno University of Technology, 61200 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-5198","authenticated-orcid":true,"given":"Tomas","family":"Zikmund","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, Brno University of Technology, 61200 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-125X","authenticated-orcid":true,"given":"Josef","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, Brno University of Technology, 61200 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-6774","authenticated-orcid":true,"given":"Marcela","family":"Buchtova","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 60200 Brno, Czech Republic."},{"name":"Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9906-4968","authenticated-orcid":true,"given":"Deborah","family":"Krakow","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8763-0424","authenticated-orcid":true,"given":"Yoshikazu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"RIBOMIC Inc., Tokyo 108-0071, Japan."},{"name":"Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-8825","authenticated-orcid":true,"given":"Keiichi","family":"Ozono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-9134","authenticated-orcid":true,"given":"Pavel","family":"Krejci","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic."},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 65691 Brno, Czech Republic."},{"name":"Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 60200 Brno, Czech Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.23.4.328"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvq121"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0945"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.094086"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.1.35"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8440-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.03.011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24479"},{"key":"e_1_3_2_10_2","first-page":"123","article-title":"Growth hormone treatment for achondroplasia","volume":"16","author":"Yorifuji T.","year":"2018","unstructured":"T. Yorifuji, S. Higuchi, R. Kawakita, Growth hormone treatment for achondroplasia. Pediatr. Endocrinol. Rev. 16, 123\u2013128 (2018).","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813446"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv441"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21636"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.158"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.07.018"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1991.31"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0496-390"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/508433"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.46.27711"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.03.021"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02618"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200302075"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.03.011"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035826"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.105536"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.08.016"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.07.015"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13775"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.6.12.1861"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/08977199109043912"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.10.013"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e318030d157"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.24.4977"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32485"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.2.140"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.730093"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2839"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20018"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds181"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006247"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1914"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83926"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.218560"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.06.014"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31343"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.09.021"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2814"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.10.014"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.06.019"},{"key":"e_1_3_2_50_2","first-page":"737","article-title":"Reversal of atrial natriuretic peptide resistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis","volume":"22","author":"Abraham W. T.","year":"1995","unstructured":"W. T. Abraham, M. E. Lauwaars, J. K. Kim, R. L. Pe\u00f1na, R. W. Schrier, Reversal of atrial natriuretic peptide resistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis. Hepatology 22, 737\u2013743 (1995).","journal-title":"Hepatology"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601252200"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.08.071"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.04.048"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.007"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21536"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085494"},{"key":"e_1_3_2_57_2","first-page":"1","article-title":"Physical growth of Swiss children from birth to 20 years of age. First Zurich longitudinal study of growth and development","volume":"52","author":"Prader A.","year":"1989","unstructured":"A. Prader, R. H. Largo, L. Molinari, C. Issler, Physical growth of Swiss children from birth to 20 years of age. First Zurich longitudinal study of growth and development. Helv. Paediatr. Acta Suppl. 52, 1\u2013125 (1989).","journal-title":"Helv. Paediatr. Acta Suppl."},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38150"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37676"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22597"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1591"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200790"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.01.016"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aba4226","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aba4226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:14:37Z","timestamp":1705407277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aba4226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":62,"journal-issue":{"issue":"592","published-print":{"date-parts":[[2021,5,5]]}},"alternative-id":["10.1126\/scitranslmed.aba4226"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aba4226","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]},"article-number":"eaba4226"}}