{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:08:39Z","timestamp":1792631319218,"version":"4.5.0"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"572","funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["634413"],"award-info":[{"award-number":["634413"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["777377"],"award-info":[{"award-number":["777377"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2020,12,2]]},"abstract":"<jats:p>A 25-gene expression signature associates with progression of fibrosing steatohepatitis in independent NAFLD cohorts.<\/jats:p>","DOI":"10.1126\/scitranslmed.aba4448","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T19:16:22Z","timestamp":1606936582000},"source":"Crossref","is-referenced-by-count":485,"title":["Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4426-6930","authenticated-orcid":true,"given":"Olivier","family":"Govaere","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6831-9806","authenticated-orcid":true,"given":"Simon","family":"Cockell","sequence":"additional","affiliation":[{"name":"Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4657-7780","authenticated-orcid":true,"given":"Dina","family":"Tiniakos","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."},{"name":"Department of Pathology, Aretaieio Hospital, National and Kapodistrian University of Athens, 15771 Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-2650","authenticated-orcid":true,"given":"Rachel","family":"Queen","sequence":"additional","affiliation":[{"name":"Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy","family":"Younes","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."},{"name":"Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Citt\u00e0 della Salute e della Scienza di Torino, University of Turin, 10124 Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-224X","authenticated-orcid":true,"given":"Michele","family":"Vacca","sequence":"additional","affiliation":[{"name":"University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-1308","authenticated-orcid":true,"given":"Leigh","family":"Alexander","sequence":"additional","affiliation":[{"name":"SomaLogic Inc., Boulder, CO 80301, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-8585","authenticated-orcid":true,"given":"Federico","family":"Ravaioli","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."},{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Palmer","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Petta","sequence":"additional","affiliation":[{"name":"Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Universit\u00e0 di Palermo, 90133 Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Boursier","sequence":"additional","affiliation":[{"name":"Hepatology Department, Angers University Hospital, 49933 Angers, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6518-7089","authenticated-orcid":true,"given":"Chiara","family":"Rosso","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Citt\u00e0 della Salute e della Scienza di Torino, University of Turin, 10124 Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-7966","authenticated-orcid":true,"given":"Katherine","family":"Johnson","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Wonders","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Day","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5590-8601","authenticated-orcid":true,"given":"Mattias","family":"Ekstedt","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, 581 83 Link\u00f6ping, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-9165","authenticated-orcid":true,"given":"Matej","family":"Ore\u0161i\u010d","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, \u00d6rebro University, 702 81 \u00d6rebro, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Darlay","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Cordell","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-0878","authenticated-orcid":true,"given":"Fabio","family":"Marra","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale e Clinica, University of Florence, 50121 Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-9577","authenticated-orcid":true,"given":"Antonio","family":"Vidal-Puig","sequence":"additional","affiliation":[{"name":"University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke\u2019s Hospital, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bedossa","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne University, ICAN (Institute of Cardiometabolism and Nutrition), 75013 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-4703","authenticated-orcid":true,"given":"J\u00f6rn M.","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Mainz, 55131 Mainz, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-3355","authenticated-orcid":true,"given":"Karine","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"Nutrition and Obesities: Systemic Approaches, INSERM, Sorbonne University, 75006 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3677-3294","authenticated-orcid":true,"given":"Michael","family":"Allison","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Medicine, NIHR Cambridge Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Bugianesi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Citt\u00e0 della Salute e della Scienza di Torino, University of Turin, 10124 Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Ratziu","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, Sorbonne University, ICAN (Institute of Cardiometabolism and Nutrition), 75013 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-0629","authenticated-orcid":true,"given":"Ann K.","family":"Daly","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9518-0088","authenticated-orcid":true,"given":"Quentin M.","family":"Anstee","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."},{"name":"NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne NE7 7DN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0145-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.034"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046584"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26661"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27695"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.05.051"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92264"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0076-1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078644"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00122"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00358.2018"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48746-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25889"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1479"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.10918"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201620"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1631-3"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29544"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.031"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.07.028"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1712191"},{"key":"e_1_3_2_26_2","first-page":"150","article-title":"17-beta hydroxysteroid dehydrogenase 13 is a hepatic retinol dehydrogenase associated with histological features of nonalcoholic fatty liver disease","volume":"69","author":"Ma Y.","year":"2018","unstructured":"Y. Ma, O. V. Belyaeva, P. M. Brown, K. Fujita, K. Valles, S. Karki, Y. S. de Boer, C. Koh, Y. Chen, X. Du, S. K. Handelman, V. Chen, E. K. Speliotes, C. Nestlerode, E. Thomas, D. E. Kleiner, J. M. Zmuda, A. J. Sanyal; Nonalcoholic Steatohepatitis Clinical Research Network, N. Y. Kedishvili, T. J. Liang, Y. Rotman, 17-beta hydroxysteroid dehydrogenase 13 is a hepatic retinol dehydrogenase associated with histological features of nonalcoholic fatty liver disease. Hepatology 69, 150\u20131519 (2018).","journal-title":"Hepatology"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10930-w"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29607"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep43446"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100166"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.08.096"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26697"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21001"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.022897"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.021"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.20.7198-7209.2003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.033530"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1911-y"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.008"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.1.134"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.06.004"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01551-3"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13587"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5228"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29477"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2020.106175"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530509100"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv300"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0665-2"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aba4448","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aba4448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:22:00Z","timestamp":1705411320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aba4448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,2]]},"references-count":53,"journal-issue":{"issue":"572","published-print":{"date-parts":[[2020,12,2]]}},"alternative-id":["10.1126\/scitranslmed.aba4448"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aba4448","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,2]]},"article-number":"eaba4448"}}