{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:48:02Z","timestamp":1790837282278,"version":"4.1.0"},"reference-count":59,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"583","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE15654"],"award-info":[{"award-number":["DE15654"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE269369"],"award-info":[{"award-number":["DE269369"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE15654"],"award-info":[{"award-number":["DE15654"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE269369"],"award-info":[{"award-number":["DE269369"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004856","name":"New York State Department of Health","doi-asserted-by":"publisher","award":["NYSTEM C029558"],"award-info":[{"award-number":["NYSTEM C029558"]}],"id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","award":["C029558"],"award-info":[{"award-number":["C029558"]}],"id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,3,3]]},"abstract":"<jats:p>Stemness of skeletal stem cells in the calvarium is maintained by BMPR1A; disruption depletes stem cells and causes cranial bone fusion.<\/jats:p>","DOI":"10.1126\/scitranslmed.abb4416","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T15:10:32Z","timestamp":1614784232000},"source":"Crossref","is-referenced-by-count":74,"title":["BMPR1A maintains skeletal stem cell properties in craniofacial development and craniosynostosis"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7322-8821","authenticated-orcid":true,"given":"Takamitsu","family":"Maruyama","sequence":"first","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA."},{"name":"Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-1650","authenticated-orcid":true,"given":"Ronay","family":"Stevens","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2696-6087","authenticated-orcid":true,"given":"Alan","family":"Boka","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5707-1115","authenticated-orcid":true,"given":"Laura","family":"DiRienzo","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-8941","authenticated-orcid":true,"given":"Connie","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Man Ivy","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Nishimori","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine and Department of Obesity and Internal Inflammation, Fukushima Medical University, Fukushima City 960-1295, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-6030","authenticated-orcid":true,"given":"Wei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA."},{"name":"Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA."},{"name":"Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"143","article-title":"Management of segmental bone defects","volume":"23","author":"Mauffrey C.","year":"2015","unstructured":"C. Mauffrey, B. T. Barlow, W. Smith, Management of segmental bone defects. J. Am. Acad. Orthop. Surg. 23, 143\u2013153 (2015).","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"e_1_3_2_3_2","first-page":"1430","article-title":"Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells","volume":"87","author":"Hernigou P.","year":"2005","unstructured":"P. Hernigou, A. Poignard, F. Beaujean, H. Rouard, Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J. Bone Joint Surg. Am. 87, 1430\u20131437 (2005).","journal-title":"J. Bone Joint Surg. Am."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"D. D. Lo D. T. Montoro M. Grova J. S. Hyun M. T. Chung D. C. Wan M. T. Longaker Stem cell\u2013based bioengineering of craniofacial bone in Stem Cells in Craniofacial Development and Regeneration G. T.-J. Huang I. Thesleff Eds. (Wiley 2013) pp. 379\u2013394.","DOI":"10.1002\/9781118498026.ch21"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488810791268618"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10526"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3139"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.042"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0989-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0662-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.06.008"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.266551.115"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07547"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1073>3.0.CO;2-F"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/35076601"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01786"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.40373"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000727"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.006"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.753"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.24.3027"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.11.2551"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9378"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.3.621"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.145532"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345810600080801"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.13.1580"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2015.5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2009.06.008"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.04.007"},{"key":"e_1_3_2_33_2","first-page":"339","article-title":"Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse","volume":"143","author":"Lim J.","year":"2016","unstructured":"J. Lim, Y. Shi, C. M. Karner, S.-Y. Lee, W.-C. Lee, G. He, F. Long, Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse. Development 143, 339\u2013347 (2016).","journal-title":"Development"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02041"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.025825"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2528"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000605)92:4<273::AID-AJMG10>3.0.CO;2-T"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32073"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0031-x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.03.041"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.12.017"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0554-8"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502033"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2006.10.002"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500124102"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10038"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2003.12.003"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092436"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/dvdy.22044","article-title":"Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells","volume":"239","author":"Hsu W.","year":"2010","unstructured":"W. Hsu, A. J. Mirando, H.-M. Ivy Yu, Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells. Dev. Dyn. 239, 338\u2013345 (2010).","journal-title":"Dev. Dyn."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056644"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.016"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904894106"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-10-116"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1830"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060310"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.407"},{"key":"e_1_3_2_58_2","first-page":"187","article-title":"A modification of Movat\u2019s pentachrome stain","volume":"94","author":"Russell H. K.","year":"1972","unstructured":"H. K. Russell Jr., A modification of Movat\u2019s pentachrome stain. Arch. Pathol. 94, 187\u2013191 (1972).","journal-title":"Arch. Pathol."},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004579"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3171"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.abb4416","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abb4416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:53:07Z","timestamp":1705409587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abb4416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":59,"journal-issue":{"issue":"583","published-print":{"date-parts":[[2021,3,3]]}},"alternative-id":["10.1126\/scitranslmed.abb4416"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abb4416","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"article-number":"eabb4416"}}