{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:14:20Z","timestamp":1793470460876,"version":"4.5.0"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"567","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI124692"],"award-info":[{"award-number":["AI124692"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI142469"],"award-info":[{"award-number":["AI142469"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>\n                    A modified regimen of benznidazole prevents\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    dormancy-dependent treatment failure in several mouse models of Chagas disease.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.abb7656","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T19:11:10Z","timestamp":1603912270000},"source":"Crossref","is-referenced-by-count":57,"title":["A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2902-7111","authenticated-orcid":true,"given":"Juan M.","family":"Bustamante","sequence":"first","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-0453","authenticated-orcid":true,"given":"Fernando","family":"Sanchez-Valdez","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA."},{"name":"Instituto de Patolog\u00eda Experimental, Universidad Nacional de Salta-CONICET, Salta, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-5667","authenticated-orcid":true,"given":"Angel M.","family":"Padilla","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0441-1355","authenticated-orcid":true,"given":"Brooke","family":"White","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-4687","authenticated-orcid":true,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-5243","authenticated-orcid":true,"given":"Rick L.","family":"Tarleton","sequence":"additional","affiliation":[{"name":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA."},{"name":"Department of Cellular Biology, University of Georgia, Athens, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.09.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064142"},{"key":"e_1_3_2_4_2","first-page":"33","article-title":"Chagas disease in Latin America: An epidemiological update based on 2010 estimates","volume":"90","author":"WHO","year":"2015","unstructured":"WHO, Chagas disease in Latin America: An epidemiological update based on 2010 estimates. Wkly. Epidemiol. Rec. 90, 33\u201344 (2015).","journal-title":"Wkly. Epidemiol. Rec."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762002000100001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.10.023"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.7.2.157"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00745-15"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2019.1577731"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34039"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit420"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0238-x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx516"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1191\/0960327106het653oa"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2007.01958.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01170-06"},{"key":"e_1_3_2_17_2","first-page":"721","article-title":"Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types","volume":"63","author":"Andrade S. G.","year":"1985","unstructured":"S. G. Andrade, J. B. Magalhaes, A. L. Pontes, Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bull. World Health Organ. 63, 721\u2013726 (1985).","journal-title":"Bull. World Health Organ."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn092"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1744"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2644"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.056"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2144-5"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.top080168"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00520-15"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30538-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"e0128707","DOI":"10.1371\/journal.pone.0128707","article-title":"Benznidazole\/itraconazole combination treatment enhances anti-Trypanosoma cruzi activity in experimental chagas disease","volume":"10","author":"Martins T. A. F.","year":"2015","unstructured":"T. A. F. Martins, L. de Figueiredo Diniz, A. L. Mazzeti, A. F. da Silva do Nascimento, S. Caldas, I. S. Caldas, I. M. de Andrade, I. Ribeiro, M. T. Bahia, Benznidazole\/itraconazole combination treatment enhances anti-Trypanosoma cruzi activity in experimental chagas disease. PLOS ONE 10, e0128707 (2015).","journal-title":"PLOS ONE"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02264-18"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19339"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05785-11"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02410-16"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000740"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"e02097-14","DOI":"10.1128\/mBio.02097-14","article-title":"CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi","volume":"6","author":"Peng D.","year":"2014","unstructured":"D. Peng, S. P. Kurup, P. Y. Yao, T. A. Minning, R. L. Tarleton, CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi. MBio 6, e02097-14 (2014).","journal-title":"MBio"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(03)00093-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-90"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.abb7656","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abb7656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:24:01Z","timestamp":1705411441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abb7656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":33,"journal-issue":{"issue":"567","published-print":{"date-parts":[[2020,10,28]]}},"alternative-id":["10.1126\/scitranslmed.abb7656"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abb7656","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"article-number":"eabb7656"}}