{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:11:07Z","timestamp":1790806267569,"version":"4.1.0"},"reference-count":75,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"606","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ID 263531414"],"award-info":[{"award-number":["ID 263531414"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ID 390857198"],"award-info":[{"award-number":["ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["CLINSPECT-M"],"award-info":[{"award-number":["CLINSPECT-M"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ED2002B"],"award-info":[{"award-number":["01ED2002B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2016-02120"],"award-info":[{"award-number":["#2016-02120"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2018-02181"],"award-info":[{"award-number":["#2018-02181"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005701","name":"\u00c5hl\u00e9n-stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005701","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Alzheimer Foundation"},{"name":"\u00c5ke Wibergs stiftelse"},{"name":"Swedish Alzheimer Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,8,11]]},"abstract":"<jats:p>\n            The\n            <jats:italic>Uppsala APP<\/jats:italic>\n            deletion leads to Alzheimer\u2019s disease by modulating \u03b1- and \u03b2-secretase cleavage of APP and by accelerating A\u03b2 fibrillization.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.abc6184","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T19:15:17Z","timestamp":1628709317000},"source":"Crossref","is-referenced-by-count":42,"title":["The\n            <i>Uppsala APP<\/i>\n            deletion causes early onset autosomal dominant Alzheimer\u2019s disease by altering APP processing and increasing amyloid \u03b2 fibril formation"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-9138","authenticated-orcid":true,"given":"Mar\u00eda","family":"Pagnon de la Vega","sequence":"first","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3423-2021","authenticated-orcid":true,"given":"Vilmantas","family":"Giedraitis","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-3604","authenticated-orcid":true,"given":"Wojciech","family":"Michno","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, University of Gothenburg, 43180 Gothenburg, Sweden."},{"name":"Department of Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Kilander","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5875-5815","authenticated-orcid":true,"given":"G\u00f6khan","family":"G\u00fcner","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) and Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-917X","authenticated-orcid":true,"given":"Mara","family":"Zielinski","sequence":"additional","affiliation":[{"name":"Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, J\u00fclich Center for Structural Biology, Forschungszentrum J\u00fclich, 52425 J\u00fclich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"L\u00f6wenmark","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RoseMarie","family":"Brundin","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2454-5086","authenticated-orcid":true,"given":"Torsten","family":"Danfors","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Radiology, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"S\u00f6derberg","sequence":"additional","affiliation":[{"name":"BioArctic AB, 11251 Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Alafuzoff","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Clinical and Experimental Pathology, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars N.G.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oslo and Oslo University Hospital, 0316 Oslo, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-1608","authenticated-orcid":true,"given":"Anna","family":"Erlandsson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-7366","authenticated-orcid":true,"given":"Dieter","family":"Willbold","sequence":"additional","affiliation":[{"name":"Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, J\u00fclich Center for Structural Biology, Forschungszentrum J\u00fclich, 52425 J\u00fclich, Germany."},{"name":"Institut f\u00fcr Physikalische Biologie, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."},{"name":"Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, State University, 141701 Dolgoprudny, Russia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-307X","authenticated-orcid":true,"given":"Stephan A.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) and Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-5431","authenticated-orcid":true,"given":"Gunnar F.","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Institute of Biological Information Processing, Structural Biochemistry (IBI-7) and JuStruct, J\u00fclich Center for Structural Biology, Forschungszentrum J\u00fclich, 52425 J\u00fclich, Germany."},{"name":"Physics Department, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-198X","authenticated-orcid":true,"given":"J\u00f6rg","family":"Hanrieder","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, University of Gothenburg, 43180 Gothenburg, Sweden."},{"name":"Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-2575","authenticated-orcid":true,"given":"Stefan F.","family":"Lichtenthaler","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) and Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, 81377 Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lannfelt","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-3859","authenticated-orcid":true,"given":"Dag","family":"Sehlin","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-8370","authenticated-orcid":true,"given":"Martin","family":"Ingelsson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, 75185 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925564"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/353844a0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.12.2087"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.6.885"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200002)47:2<249::AID-ANA18>3.0.CO;2-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.18.2589"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0182-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20402"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.06.012"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-143231"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0392-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.11993"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01137-0"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-864"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111584"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.178"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0692-218"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1009"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901-887"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05263.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.4.499"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.10.022"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-60"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11283"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.589069"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.599027"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080480"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12532"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.167"},{"key":"e_1_3_3_34_2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1471-4159.2007.04759.x","article-title":"Sensitive ELISA detection of amyloid-beta protofibrils in biological samples","volume":"103","author":"Englund H.","year":"2007","unstructured":"H. Englund, D. Sehlin, A. S. Johansson, L. N. Nilsson, P. Gellerfors, S. Paulie, L. Lannfelt, F. E. Pettersson, Sensitive ELISA detection of amyloid-beta protofibrils in biological samples. J. Neurochem. 103, 334\u2013345 (2007).","journal-title":"J. Neurochem."},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2825"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503455112"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05129"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600749113"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.09.92"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.13.6075"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.10.003"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899456"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160115697"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1159\/000203774"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.395608"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120994"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi5003053"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.90.104"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14864"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9762"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1992-1"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00676"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031084"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0075-0"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-017-0289-z"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0461-5"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.109"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c47cc2"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw002"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.11.022"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006604"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1ob05637a"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713215114"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr050475v"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr0703627"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/jms.2987"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.2174\/1386207053258488"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.08.011"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.173"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12508"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20145625"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42166"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2015.08.008"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.abc6184","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abc6184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:45:43Z","timestamp":1705427143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abc6184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":75,"journal-issue":{"issue":"606","published-print":{"date-parts":[[2021,8,11]]}},"alternative-id":["10.1126\/scitranslmed.abc6184"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abc6184","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]},"article-number":"eabc6184"}}