{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:03Z","timestamp":1793640723105,"version":"4.5.1"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"600","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL127717"],"award-info":[{"award-number":["R01 HL127717"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL 130804"],"award-info":[{"award-number":["HL 130804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL 118761"],"award-info":[{"award-number":["HL 118761"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18POST34060186"],"award-info":[{"award-number":["18POST34060186"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MacDonald Research Fund Award","award":["16RDM001"],"award-info":[{"award-number":["16RDM001"]}]},{"DOI":"10.13039\/100019895","name":"Vivian L. Smith Foundation","doi-asserted-by":"crossref","award":["14CVD01"],"award-info":[{"award-number":["14CVD01"]}],"id":[{"id":"10.13039\/100019895","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,6,30]]},"abstract":"<jats:p>Gene therapy\u2013mediated disruption of Hippo signaling results in tissue renewal and improved function in pigs after myocardial infarction.<\/jats:p>","DOI":"10.1126\/scitranslmed.abd6892","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T15:12:13Z","timestamp":1625065933000},"source":"Crossref","is-referenced-by-count":148,"title":["Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-5416","authenticated-orcid":true,"given":"Shijie","family":"Liu","sequence":"first","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-9260","authenticated-orcid":true,"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Wagner Florencio","sequence":"additional","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6003-8743","authenticated-orcid":true,"given":"Todd R.","family":"Heallen","sequence":"additional","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-8583","authenticated-orcid":true,"given":"John P.","family":"Leach","sequence":"additional","affiliation":[{"name":"Department of Medicine, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-6506","authenticated-orcid":true,"given":"Yidan","family":"Wang","sequence":"additional","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Grisanti","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Willerson","sequence":"additional","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-9814","authenticated-orcid":true,"given":"Emerson C.","family":"Perin","sequence":"additional","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-9857","authenticated-orcid":true,"given":"James F.","family":"Martin","sequence":"additional","affiliation":[{"name":"Texas Heart Institute, Houston, TX, USA."},{"name":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA."},{"name":"Center for Organ Repair and Renewal and Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-018-1011-x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98215"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam5894"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.026"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11682"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408233111"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200708"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031542"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034886"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307017"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311062"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24045"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22978"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22979"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1191-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010841"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.01.017"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.64"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0063-3"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005781"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102798"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00117"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000149531.02904.09"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.10.007"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701491"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003170"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1299-0"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2015.04.005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.07.004"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx180"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.10.029"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021119-034618"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01159"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.12.022"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000175117"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.047"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.045"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.329763.119"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.005"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.08.009"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1089\/hgtb.2012.243"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2017.150"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0137"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.01.021"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.9.965"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312978"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_2_51_2","first-page":"51269","article-title":"Myocardial infarction and functional outcome assessment in pigs","volume":"2014","author":"Koudstaal S.","year":"2014","unstructured":"S. Koudstaal, S. J. Lorkeers, J. M. I. H. Gho, G. P. J. van Hout, M. S. Jansen, P. F. Gr\u00fcndeman, G. Pasterkamp, P. A. Doevendans, I. E. Hoefer, S. A. J. Chamuleau, Myocardial infarction and functional outcome assessment in pigs. J. Vis. Exp. 2014, 51269 (2014).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305462"},{"key":"e_1_3_2_53_2","first-page":"30","article-title":"Qualitative and quantitative evaluation of two new histogram limiting binarization algorithms","volume":"8","author":"Brocher J.","year":"2014","unstructured":"J. Brocher, Qualitative and quantitative evaluation of two new histogram limiting binarization algorithms. Int. J. Image Process. 8, 30\u201348 (2014).","journal-title":"Int. J. Image Process."}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.abd6892","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abd6892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:45:11Z","timestamp":1705412711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abd6892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":52,"journal-issue":{"issue":"600","published-print":{"date-parts":[[2021,6,30]]}},"alternative-id":["10.1126\/scitranslmed.abd6892"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abd6892","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"article-number":"eabd6892"}}