{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:57:51Z","timestamp":1792684671108,"version":"4.5.0"},"reference-count":51,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"581","funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG062027"],"award-info":[{"award-number":["AG062027"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG047644"],"award-info":[{"award-number":["AG047644"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2P30AG019610"],"award-info":[{"award-number":["2P30AG019610"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["OD021629"],"award-info":[{"award-number":["OD021629"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5T32GM008151"],"award-info":[{"award-number":["5T32GM008151"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS103276"],"award-info":[{"award-number":["NS103276"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,2,17]]},"abstract":"<jats:p>Targeting APOE using an anti-APOE antibody ameliorates amyloid pathology while protecting cerebrovascular integrity and function.<\/jats:p>","DOI":"10.1126\/scitranslmed.abd7522","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T15:54:05Z","timestamp":1613577245000},"source":"Crossref","is-referenced-by-count":158,"title":["APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-1814","authenticated-orcid":true,"given":"Monica","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Division of Biology and Biomedical Sciences (DBBS), Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6480-7469","authenticated-orcid":true,"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Remolina","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto R.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Gratuze","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-424X","authenticated-orcid":true,"given":"Rosa","family":"Hoyle","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nga","family":"Bien-Ly","sequence":"additional","affiliation":[{"name":"Denali Therapeutics, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-6607","authenticated-orcid":true,"given":"Adam P.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Codexis, Redwood City, CA 94063, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-2634","authenticated-orcid":true,"given":"Patrick M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-5089","authenticated-orcid":true,"given":"Ryan J.","family":"Watts","sequence":"additional","affiliation":[{"name":"Denali Therapeutics, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-926X","authenticated-orcid":true,"given":"Jason D.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-0856","authenticated-orcid":true,"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70015-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-1-24"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4337-04.2005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1078259"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.1538"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0318-y"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0281-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1064-y"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91092-F"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.10.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002156"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121274"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0646-14.2014"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96429"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0250-y"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt233"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4686-08.2008"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv313"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.188"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0718-6"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.018"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.08.008"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0228-7"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1302"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00133.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","unstructured":"S. Budd-Haeberlein C. Von Hein Y. Tian S. Chalkias K. K. Muralidharan EMERGE and ENGAGE topline results: Two phase 3 studies to evaluate aducanumab in patients with early Alzheimer\u2019s disease in Clinical Trials on Alzheimer\u2019s Disease Conference (San Diego CA 2019) pp. 1\u201360.","DOI":"10.1002\/alz.047259"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005550"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.06.1893"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.761"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190980"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5170-04.2005"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01900-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0337-1"},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/MOL.0000000000000383","article-title":"Apolipoprotein E metabolism and functions in brain and its role in Alzheimer\u02bcs disease","volume":"28","author":"Liao F.","year":"2016","unstructured":"F. Liao, H. Yoon, J. Kim, Apolipoprotein E metabolism and functions in brain and its role in Alzheimer\u02bcs disease. Curr. Opin. Lipidol. 28, 60\u201367 (2016).","journal-title":"Curr. Opin. Lipidol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.05.007"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508780200"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1937-12.2012"},{"key":"e_1_3_2_45_2","first-page":"671","article-title":"Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease","volume":"118","author":"Wahrle S. E.","year":"2008","unstructured":"S. E. Wahrle, H. Jiang, M. Parsadanian, J. Kim, A. Li, A. Knoten, S. Jain, V. Hirsch-Reinshagen, C. L. Wellington, K. R. Bales, S. M. Paul, D. M. Holtzman, Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J. Clin. Invest. 118, 671\u2013682 (2008).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217697"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.396"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414930112"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.29.17972"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701137114"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24016"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.abd7522","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abd7522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:14:46Z","timestamp":1705407286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abd7522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":51,"journal-issue":{"issue":"581","published-print":{"date-parts":[[2021,2,17]]}},"alternative-id":["10.1126\/scitranslmed.abd7522"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abd7522","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"article-number":"eabd7522"}}