{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:51:44Z","timestamp":1793382704511,"version":"4.5.0"},"reference-count":86,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"579","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,2,3]]},"abstract":"<jats:p>A smartwatch-based sensing system measures tremor and dyskinesia, enabling remote monitoring and aiding medication titration in Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1126\/scitranslmed.abd7865","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T15:11:20Z","timestamp":1612365080000},"source":"Crossref","is-referenced-by-count":208,"title":["Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson\u2019s disease"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9161-0303","authenticated-orcid":true,"given":"Rob","family":"Powers","sequence":"first","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Etezadi-Amoli","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4060-133X","authenticated-orcid":true,"given":"Sara","family":"Kianian","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."},{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irida","family":"Mance","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-4762","authenticated-orcid":true,"given":"Maxsim","family":"Gibiansky","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Trietsch","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Singh","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Kretlow","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-7418","authenticated-orcid":true,"given":"Todd M.","family":"Herrington","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA."},{"name":"Department of Neurology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-4611","authenticated-orcid":true,"given":"Salima","family":"Brillman","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Disease and Movement Center of Silicon Valley, Menlo Park, CA 94025, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengchun","family":"Huang","sequence":"additional","affiliation":[{"name":"Silicon Valley Parkinson\u2019s Center, Los Gatos, CA 95032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-7763","authenticated-orcid":true,"given":"Peter T.","family":"Lin","sequence":"additional","affiliation":[{"name":"Silicon Valley Parkinson\u2019s Center, Los Gatos, CA 95032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung A.","family":"Pham","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-6754","authenticated-orcid":true,"given":"Adeeti V.","family":"Ullal","sequence":"additional","affiliation":[{"name":"Apple Inc., Cupertino, CA 95014, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000484"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.14781"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa3487"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001953"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-016-0663-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao3612"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1145\/2629633"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2016.09.001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-020-0305-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1109\/TITB.2009.2033471"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-160936"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.21037\/mhealth.2016.04.02"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"L. Li Q. Yu B. Xu Q. Bai Y. Zhang H. Zhang C. Mao C. Liu T. Shen S. Wang Multi-Sensor Wearable Devices for Movement Monitoring in Parkinson\u2019s Disease. 2017 8th International IEEE\/EMBS Conference on Neural Engineering (NER) (IEEE 2017) pp. 70\u201373.","DOI":"10.1109\/NER.2017.8008294"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189161"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-2767-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0809"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/s19214764"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/s19194215"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191781"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21667"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.ra.2018-0045"},{"issue":"3","key":"e_1_3_2_23_2","first-page":"2","article-title":"Consensus statement of the movement disorder society on tremor. Ad Hoc scientific committee","volume":"13","author":"Deuschl G.","year":"1998","unstructured":"G. Deuschl, P. Bain, M. Brin, Consensus statement of the movement disorder society on tremor. Ad Hoc scientific committee. Mov. Disord. 13 ( suppl. 3), 2\u201323 (1998).","journal-title":"Mov. Disord."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10473"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2009.09.001"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199010000-00004"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200003000-00003"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2011.00253.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000477383","article-title":"The first frontier: Digital biomarkers for neurodegenerative disorders","volume":"1","author":"Dorsey E. R.","year":"2017","unstructured":"E. R. Dorsey, S. Papapetropoulos, M. Xiong, K. Kieburtz, The first frontier: Digital biomarkers for neurodegenerative disorders. Digit. Biomark. 1, 6\u201313 (2017).","journal-title":"Digit. Biomark."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-019-0214-x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.07.002"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402233100802"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050464"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00052-0"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S1660"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2010.05459.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.09.004"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.01036"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199909000-00010"},{"key":"e_1_3_2_41_2","first-page":"4954","article-title":"Implementation of an iPhone for characterizing Parkinson\u2019s disease tremor through a wireless accelerometer application","volume":"2010","author":"Lemoyne R.","year":"2010","unstructured":"R. Lemoyne, T. Mastroianni, M. Cozza, C. Coroian, W. Grundfest, Implementation of an iPhone for characterizing Parkinson\u2019s disease tremor through a wireless accelerometer application. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2010, 4954\u20134958 (2010).","journal-title":"Annu. Int. Conf. IEEE Eng. Med. Biol. Soc."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2014.2310904"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/s151025055"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2172-0_23"},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","unstructured":"O. Bazgir J. Frounchi S. A. H. Habibi L. Palma P. Pierleoni A neural network system for diagnosis and assessment of tremor in Parkinson disease patients. 2015 22nd Iranian Conference on Biomedical Engineering (ICBME) (IEEE 2015) pp. 1\u20135.","DOI":"10.1109\/ICBME.2015.7404105"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/aa8e1f"},{"key":"e_1_3_2_47_2","first-page":"3144","article-title":"A deep learning framework for the remote detection of Parkinson\u2019S disease using smart-phone sensor data","volume":"2018","author":"Prince J.","year":"2018","unstructured":"J. Prince, M. de Vos, A deep learning framework for the remote detection of Parkinson\u2019S disease using smart-phone sensor data. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2018, 3144\u20133147 (2018).","journal-title":"Annu. Int. Conf. IEEE Eng. Med. Biol. Soc."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2018.00072"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/s19194301"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-2012-11071"},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","unstructured":"S. Arora V. Venkataraman S. Donohue K. M. Biglan E. R. Dorsey M. A. Little High accuracy discrimination of Parkinson\u2019s disease participants from healthy controls using smartphones. 2014 IEEE International Conference on Acoustics Speech and Signal Processing (ICASSP) (IEEE 2014) pp. 3641\u20133644.","DOI":"10.1109\/ICASSP.2014.6854280"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.02.026"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-160898"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.11"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-016-0003-z"},{"key":"e_1_3_2_56_2","doi-asserted-by":"crossref","first-page":"P3.045","DOI":"10.1212\/WNL.90.15_supplement.P3.045","article-title":"Clinical experience with personal KinetiGraph before and after deep brain stimulation for Parkinson\u2019s disease (P3.045)","volume":"90","author":"Gernon S.","year":"2018","unstructured":"S. Gernon, A. Fowler, K. Lyons, R. Pahwa, Clinical experience with personal KinetiGraph before and after deep brain stimulation for Parkinson\u2019s disease (P3.045). Neurology 90, P3.045 (2018).","journal-title":"Neurology"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1503948"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.01.025"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/s19102241"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2017.03.006"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181373"},{"key":"e_1_3_2_62_2","first-page":"21","article-title":"The role of Personal KinetiGraphTM fluctuator score in quantifying the progression of motor fluctuations in Parkinson\u2019s disease","volume":"34","author":"Tan E. E.","year":"2019","unstructured":"E. E. Tan, E. J. Hogg, M. Tagliati, The role of Personal KinetiGraphTM fluctuator score in quantifying the progression of motor fluctuations in Parkinson\u2019s disease. Funct. Neurol. 34, 21\u201328 (2019).","journal-title":"Funct. Neurol."},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488407781668802"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.06.020"},{"key":"e_1_3_2_65_2","first-page":"S2","article-title":"The spectrum of Levodopa-induced dyskinesias","volume":"47","author":"Fahn S.","year":"2000","unstructured":"S. Fahn, The spectrum of Levodopa-induced dyskinesias. Ann. Neurol. 47, S2\u2013S9 (2000).","journal-title":"Ann. Neurol."},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21475"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.10.002"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004238"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.11.024"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/s140304618"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25548"},{"key":"e_1_3_2_72_2","first-page":"37","article-title":"Smartphone based timed up and go test can identify postural instability in Parkinson\u2019s disease","volume":"22","author":"Yahalom G.","year":"2020","unstructured":"G. Yahalom, Z. Yekutieli, S. Israeli-Korn, S. Elincx-Benizri, V. Livneh, T. Fay-Karmon, K. Tchelet, Y. Rubel, S. Hassin-Baer, Smartphone based timed up and go test can identify postural instability in Parkinson\u2019s disease. Isr. Med. Assoc. J. 22, 37\u201342 (2020).","journal-title":"Isr. Med. Assoc. J."},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2017.05.023"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27671"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-018-0030-8"},{"key":"e_1_3_2_76_2","first-page":"108","article-title":"Using cloud-based physical activity data from google fit and apple healthkit to expand recording of physical activity data in a population study","volume":"245","author":"Henriksen H. L.","year":"2017","unstructured":"H. L. Henriksen, G. Hartvigsen, S. Grimsgaard, Using cloud-based physical activity data from google fit and apple healthkit to expand recording of physical activity data in a population study. Stud. Health Technol. Inform. 245, 108\u2013112 (2017).","journal-title":"Stud. Health Technol. Inform."},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.326"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004025"},{"key":"e_1_3_2_79_2","unstructured":"M. Schroeder K161717: Personal Kinetigraph (PKG) System Model GKC-2000 (U.S. FDA Department of Health and Human Services 2016)."},{"key":"e_1_3_2_80_2","unstructured":"D.-B. Tillman DEN180044: ECG App (U.S. FDA U.S. FDA CDRH 2018)."},{"key":"e_1_3_2_81_2","unstructured":"D.-B. Tillman DEN180042: Irregular Rhythm Notification Feature (U.S. FDA U.S. FDA CDRH 2018)."},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09183-6"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27376"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.10.008"},{"key":"e_1_3_2_85_2","unstructured":"Apple Inc. (ORKParkinsonStudy GitHub Open Source Repository GitHub 2018); https:\/\/github.com\/ResearchKit\/ResearchKit\/tree\/master\/samples\/ORKParkinsonStudy."},{"key":"e_1_3_2_86_2","unstructured":"Apple Inc. Movement Disorder API Developer Documentation (Apple Developer Documentation); https:\/\/developer.apple.com\/documentation\/coremotion."},{"key":"e_1_3_2_87_2","unstructured":"W. R. Powers III M. Etezadi-Amoli A. V. Ullal D. Trietsch S. Kianian H. A. Pham Passive tracking of dyskinesia\/tremor symptoms. U.S. Patent 20190365286 (2019)."}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abd7865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:33:14Z","timestamp":1705408394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abd7865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":86,"journal-issue":{"issue":"579","published-print":{"date-parts":[[2021,2,3]]}},"alternative-id":["10.1126\/scitranslmed.abd7865"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abd7865","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,3]]},"article-number":"eabd7865"}}