{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:37:23Z","timestamp":1793050643446,"version":"4.5.0"},"reference-count":76,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"625","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,12,22]]},"abstract":"<jats:p>Use of systemic antibiotics induces substantial changes in the microbiome and expansion of antimicrobial resistant bacteria.<\/jats:p>","DOI":"10.1126\/scitranslmed.abd8077","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T13:53:47Z","timestamp":1640181227000},"source":"Crossref","is-referenced-by-count":116,"title":["Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-3425","authenticated-orcid":true,"given":"Jay-Hyun","family":"Jo","sequence":"first","affiliation":[{"name":"Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona P.","family":"Harkins","sequence":"additional","affiliation":[{"name":"Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA."},{"name":"Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-9270","authenticated-orcid":true,"given":"Nicole H.","family":"Schwardt","sequence":"additional","affiliation":[{"name":"Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-5624","authenticated-orcid":true,"given":"Jessica A.","family":"Portillo","sequence":"additional","affiliation":[{"name":"Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NISC Comparative Sequencing Program","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4390-3555","authenticated-orcid":true,"given":"Matthew D.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-7621","authenticated-orcid":true,"given":"Claire L.","family":"Carter","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Amir","family":"Hossen","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9395-3473","authenticated-orcid":true,"given":"Cody J.","family":"Peer","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5152-8740","authenticated-orcid":true,"given":"Eric C.","family":"Polley","sequence":"additional","affiliation":[{"name":"Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20850, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-5009","authenticated-orcid":true,"given":"V\u00e9ronique","family":"Dartois","sequence":"additional","affiliation":[{"name":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-5613","authenticated-orcid":true,"given":"William D.","family":"Figg","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-6735","authenticated-orcid":true,"given":"Niki M.","family":"Moutsopoulos","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6860-348X","authenticated-orcid":true,"given":"Julia A.","family":"Segre","sequence":"additional","affiliation":[{"name":"Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-064X","authenticated-orcid":true,"given":"Heidi H.","family":"Kong","sequence":"additional","affiliation":[{"name":"Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA."},{"name":"Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","unstructured":"Centers for Disease Control and Prevention Outpatient antibiotic prescriptions\u2014United States (2017)."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.3842"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx502"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.008"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-16-3-271"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1988.tb03667.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15000"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00774-17"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.5221"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225152"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.014"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000067821"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0267-z"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw586"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00840.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.131029.111"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0211-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.106"},{"key":"e_1_3_3_22_2","first-page":"S113","article-title":"Temporal shifts in the skin microbiome associated with atopic dermatitis disease flares and treatment","volume":"132","author":"Kong H. H.","year":"2012","unstructured":"H. H. Kong, J. Oh, S. Conlan, C. Deming, E. A. Grice, M. L. Turner, J. A. Segre, Temporal shifts in the skin microbiome associated with atopic dermatitis disease flares and treatment. J. Investig. Dermatol. 132, S113\u2013S113 (2012).","journal-title":"J. Investig. Dermatol."},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00193"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01884"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15766"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060280"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009836"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13786"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.157"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/STA-200066418"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177486"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000087107"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0187-9"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095476"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-019-0692-y"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.11.034"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025387"},{"key":"e_1_3_3_39_2","first-page":"e000075","article-title":"Bayesian identification of bacterial strains from sequencing data","volume":"2","author":"Sankar A.","year":"2016","unstructured":"A. Sankar, B. Malone, S. C. Bayliss, B. Pascoe, G. Meric, M. D. Hitchings, S. K. Sheppard, E. J. Feil, J. Corander, A. Honkela, Bayesian identification of bacterial strains from sequencing data. Microb. Genom. 2, e000075 (2016).","journal-title":"Microb. Genom."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0294-z"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics2010100"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12077"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0257-9"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2007.3"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2536"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-014-0504-4"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000140034006"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb08270.x"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu658"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.068"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254529"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00018-16"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-018-1191-3"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13721"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00058-2.x"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-5419-x"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00489-08"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3151"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0087"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.11.010"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.171-177.2006"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/38.5.829"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0894-4"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-119"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl158"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq461"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_3_70_2","first-page":"57402","article-title":"Spatial quantification of drugs in pulmonary tuberculosis lesions by laser capture microdissection liquid chromatography mass spectrometry (LCM-LC\/MS)","author":"Zimmerman M.","year":"2018","unstructured":"M. Zimmerman, L. Blanc, P.-Y. Chen, V. Dartois, B. Prideaux, Spatial quantification of drugs in pulmonary tuberculosis lesions by laser capture microdissection liquid chromatography mass spectrometry (LCM-LC\/MS). J. Vis. Exp. , 57402 (2018).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3589"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0090-6"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1196"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msp077"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00444-16"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0230-7"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2017.126"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abd8077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:15:30Z","timestamp":1705410930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abd8077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":76,"journal-issue":{"issue":"625","published-print":{"date-parts":[[2021,12,22]]}},"alternative-id":["10.1126\/scitranslmed.abd8077"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abd8077","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,22]]},"article-number":"eabd8077"}}