{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:30:16Z","timestamp":1784565016519,"version":"3.55.0"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"601","funder":[{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["203581\/Z\/16\/Z"],"award-info":[{"award-number":["203581\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N013204\/1"],"award-info":[{"award-number":["MR\/N013204\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N026993\/1"],"award-info":[{"award-number":["MR\/N026993\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["NF-SI-0617-10010"],"award-info":[{"award-number":["NF-SI-0617-10010"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["IS-BRC-1215-20004"],"award-info":[{"award-number":["IS-BRC-1215-20004"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,7,7]]},"abstract":"<jats:p>An engineered commensal bacteria with a surface-expressed vaccine target provoked antigen-specific antibodies during pharyngeal carriage in humans.<\/jats:p>","DOI":"10.1126\/scitranslmed.abe8573","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T15:25:03Z","timestamp":1625671503000},"source":"Crossref","is-referenced-by-count":12,"title":["A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-5989","authenticated-orcid":true,"given":"Jay R.","family":"Laver","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Gbesemete","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-7481","authenticated-orcid":true,"given":"Adam P.","family":"Dale","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe C.","family":"Pounce","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-4397","authenticated-orcid":true,"given":"Carl N.","family":"Webb","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor F.","family":"Roche","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Guy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Berreen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6505-6476","authenticated-orcid":true,"given":"Konstantinos","family":"Belogiannis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5397-873X","authenticated-orcid":true,"given":"Alison R.","family":"Hill","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-3095","authenticated-orcid":true,"given":"Muktar M.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3234-2788","authenticated-orcid":true,"given":"Muhammad","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4533-0700","authenticated-orcid":true,"given":"David W.","family":"Cleary","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4149-8154","authenticated-orcid":true,"given":"Anish K.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2576-8502","authenticated-orcid":true,"given":"Holly E.","family":"Humphries","sequence":"additional","affiliation":[{"name":"Public Health England, Porton Down, Salisbury SP4 0JG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-8181","authenticated-orcid":true,"given":"Lauren","family":"Allen","sequence":"additional","affiliation":[{"name":"Public Health England, Porton Down, Salisbury SP4 0JG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-8749","authenticated-orcid":true,"given":"Hans","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-5138","authenticated-orcid":true,"given":"Martin C.","family":"Maiden","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-7642","authenticated-orcid":true,"given":"Saul N.","family":"Faust","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-7954","authenticated-orcid":true,"given":"Andrew R.","family":"Gorringe","sequence":"additional","affiliation":[{"name":"Public Health England, Porton Down, Salisbury SP4 0JG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-6728","authenticated-orcid":true,"given":"Robert C.","family":"Read","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/431524"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114758"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/515622"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/137.2.112"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq065"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ098"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07235-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.07.064"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.synbio.2018.12.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-016-0468-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-020-01318-z"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058709"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6685-6690.2000"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.06161-11"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01521-14"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-273813"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01322-10"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04423.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00751"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00118-09"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1904.111799"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.3.545"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00078"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.03.091"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2003.12.015"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802531"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-211052"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055531"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2507"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114159"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.11.1597"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.7.4052-4060.2004"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/424464"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000606"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00102-07"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir198"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419686111"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22057-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.4969"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188454"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201730"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.71"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026544"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1042\/BA20040098"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.053"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025089"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.09.102"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.004"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40793-017-0288-5"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/14.5.1991"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5459.1809"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(85)90120-9"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.abe8573","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abe8573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:37:41Z","timestamp":1705408661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abe8573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":52,"journal-issue":{"issue":"601","published-print":{"date-parts":[[2021,7,7]]}},"alternative-id":["10.1126\/scitranslmed.abe8573"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abe8573","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.06.20093450","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,7]]},"article-number":"eabe8573"}}