{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:00:34Z","timestamp":1791223234264,"version":"4.1.0"},"reference-count":92,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"641","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,4,20]]},"abstract":"<jats:p>\n            The fetal brain is constantly exposed to maternal IgG before the formation of an effective blood-brain barrier (BBB). Here, we studied the consequences of fetal brain exposure to an antibody to the astrocytic protein aquaporin-4 (AQP4-IgG) in mice. AQP4-IgG was cloned from a patient with neuromyelitis optica spectrum disorder (NMOSD), an autoimmune disease that can affect women of childbearing age. We found that embryonic radial glia cells in neocortex express AQP4. These cells are critical for blood vessel and BBB formation through modulation of the WNT signaling pathway. Male fetuses exposed to AQP4-IgG had abnormal cortical vasculature and lower expression of WNT signaling molecules\n            <jats:italic>Wnt<\/jats:italic>\n            5a and\n            <jats:italic>Wnt<\/jats:italic>\n            7a. Positron emission tomography of adult male mice exposed in utero to AQP4-IgG revealed increased blood flow and BBB leakiness in the entorhinal cortex. Adult male mice exposed in utero to AQP4-IgG had abnormal cortical vessels, fewer dendritic spines in pyramidal and stellate neurons, and more S100\u03b2\n            <jats:sup>+<\/jats:sup>\n            astrocytes in the entorhinal cortex. Behaviorally, they showed impairments in the object-place memory task. Neural recordings indicated that their grid cell system, within the medial entorhinal cortex, did not map the local environment appropriately. Collectively, these data implicate in utero binding of AQP4-IgG to radial glia cells as a mechanism for alterations of the developing male brain and adds NMOSD to the conditions in which maternal IgG may cause persistent brain dysfunction in offspring.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.abe9726","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T17:52:41Z","timestamp":1650477161000},"source":"Crossref","is-referenced-by-count":20,"title":["In utero exposure to maternal anti\u2013aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspring"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-9091","authenticated-orcid":true,"given":"Simone","family":"Mader","sequence":"first","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."},{"name":"Institute of Clinical Neuroimmunology, Biomedical Center of the Ludwig Maximilian University of Munich, Munich 82152, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-3053","authenticated-orcid":true,"given":"Lior","family":"Brimberg","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4961-536X","authenticated-orcid":true,"given":"An","family":"Vo","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-061X","authenticated-orcid":true,"given":"Joshua J.","family":"Strohl","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."},{"name":"Department of Molecular Medicine, Zucker School of Medicine at Hofstra\/Northwell, Manhasset, NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-1093","authenticated-orcid":true,"given":"James M.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Northwell Health, Manhasset, NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bonnin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurosciences, Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Carri\u00f3n","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delcora","family":"Campbell","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s S.","family":"Huerta","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."},{"name":"Department of Molecular Medicine, Zucker School of Medicine at Hofstra\/Northwell, Manhasset, NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-1531","authenticated-orcid":true,"given":"Andrea","family":"La Bella","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8686-0989","authenticated-orcid":true,"given":"Roseann","family":"Berlin","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Dewey","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-9395","authenticated-orcid":true,"given":"Matthew","family":"Hellman","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-864X","authenticated-orcid":true,"given":"David","family":"Eidelberg","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-1901","authenticated-orcid":true,"given":"Irena","family":"Dujmovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia University School of Medicine, Belgrade, 11000, Serbia."},{"name":"Department of Neurology, University of North Carolina, School of Medicine, Chapel Hill, NC 27517, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4516-3458","authenticated-orcid":true,"given":"Jelena","family":"Drulovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia University School of Medicine, Belgrade, 11000, Serbia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3346-1394","authenticated-orcid":true,"given":"Jeffrey L.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Neurology and Ophthalmology, Programs in Neuroscience and Immunology, University of Colorado Denver, School of Medicine, Denver, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1098-1848","authenticated-orcid":true,"given":"Bruce T.","family":"Volpe","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-2308","authenticated-orcid":true,"given":"Patricio T.","family":"Huerta","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."},{"name":"Department of Molecular Medicine, Zucker School of Medicine at Hofstra\/Northwell, Manhasset, NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-3804","authenticated-orcid":true,"given":"Betty","family":"Diamond","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, Manhasset NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2445"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39320"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002208"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.7.913"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21837"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21802"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1950-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp309"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI122942"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900866"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1501-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-85"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318250d812"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7031-y"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824c466f"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515583376"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4026"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.11.054"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009759"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075041"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.09.008"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1892"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111986"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.165"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.06.001"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.041002.131058"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10244"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2015.07.004"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200806024"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805165106"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164594"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-09-0582"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001469"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.245"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01599"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00243-4"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619300114"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109980108"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102641"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301483"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.188"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl371"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.07.014"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.067"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.008"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.09.016"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00202"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20472"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.050"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.389"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006392"},{"key":"e_1_3_3_55_2","doi-asserted-by":"crossref","unstructured":"D. Prilutsky A. Kho A. Feiglin T. Hammond B. Stevens I. S. Kohane Sexual dimorphism of complement-dependent microglial synaptic pruning and other immune pathways in the developing brain. biorxiv 204412 [ Preprint ] (2017). https:\/\/doi.org\/10.1101\/204412.","DOI":"10.1101\/204412"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1581"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.6158"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.02.011"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-16"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20253"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6249-10.2011"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.05.003"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14152"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00129"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0121"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.611731"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00563.2005"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7631"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401973"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2020.151573"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2.1.26"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e2414b"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5381239"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.150698"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.003"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00236"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2021.663667"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23117"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010455"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-184"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513698112"},{"key":"e_1_3_3_82_2","first-page":"277","article-title":"Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents","volume":"48","author":"Schiffer W. K.","year":"2007","unstructured":"W. K. Schiffer, M. M. Mirrione, S. L. Dewey, Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents. J. Nucl. Med. 48, 277\u2013287 (2007).","journal-title":"J. Nucl. Med."},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.09.017"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900551"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2012.00195"},{"key":"e_1_3_3_86_2","first-page":"Unit 8.24","article-title":"Simple behavioral assessment of mouse olfaction","volume":"8","author":"Yang M.","year":"2009","unstructured":"M. Yang, J. N. Crawley, Simple behavioral assessment of mouse olfaction. Curr. Protoc. Neurosci. Chapter 8, Unit 8.24 (2009).","journal-title":"Curr. Protoc. Neurosci."},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.05.027"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180776"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.011"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.07.014"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2012.00046"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81827-9"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00121"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abe9726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:19:50Z","timestamp":1705425590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abe9726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":92,"journal-issue":{"issue":"641","published-print":{"date-parts":[[2022,4,20]]}},"alternative-id":["10.1126\/scitranslmed.abe9726"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abe9726","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]},"article-number":"eabe9726"}}