{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:16:39Z","timestamp":1790432199965,"version":"4.1.0"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"597","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["6001-09"],"award-info":[{"award-number":["6001-09"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005624","name":"PATH","doi-asserted-by":"publisher","award":["145-08"],"award-info":[{"award-number":["145-08"]}],"id":[{"id":"10.13039\/100005624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,6,9]]},"abstract":"<jats:p>\n            Two\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            vaccine candidates, Pf77 and PfMDV-1, have multistage expression and induce antibodies that reduce parasite transmission.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.abg2112","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T19:25:51Z","timestamp":1623266751000},"source":"Crossref","is-referenced-by-count":11,"title":["<i>Plasmodium falciparum<\/i>\n            Pf77 and male development gene 1 as vaccine antigens that induce potent transmission-reducing antibodies"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-0142","authenticated-orcid":true,"given":"Abhai K.","family":"Tripathi","sequence":"first","affiliation":[{"name":"Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda S.","family":"Oakley","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Verma","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-9710","authenticated-orcid":true,"given":"Godfree","family":"Mlambo","sequence":"additional","affiliation":[{"name":"Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7750-7545","authenticated-orcid":true,"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Meredith","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Essuman","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8054-0917","authenticated-orcid":true,"given":"Ankit","family":"Puri","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Skelton","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyo","family":"Takeda","sequence":"additional","affiliation":[{"name":"Division of Bacterial, Parasitic, and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Majam","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella A.","family":"Quakyi","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Ghana, Accra, Ghana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-8473","authenticated-orcid":true,"given":"Emily","family":"Locke","sequence":"additional","affiliation":[{"name":"PATH-Malaria Vaccine Initiative, Washington, DC 20001, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merribeth","family":"Morin","sequence":"additional","affiliation":[{"name":"PATH-Malaria Vaccine Initiative, Washington, DC 20001, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-2432","authenticated-orcid":true,"given":"Kazutoyo","family":"Miura","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-5443","authenticated-orcid":true,"given":"Carole A.","family":"Long","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-9354","authenticated-orcid":true,"given":"Sanjai","family":"Kumar","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization World Malaria Report 2020\u201420 Years of Global Progress and Changes (World Health Organization Geneva 2020); https:\/\/cdn.who.int\/media\/docs\/default-source\/malaria\/world-malaria-reports\/9789240015791-eng.pdf?sfvrsn=d7a8ec53_3&download=true."},{"key":"e_1_3_2_3_2","first-page":"93","article-title":"Climate, environment and transmission of malaria","volume":"24","author":"Rossati A.","year":"2016","unstructured":"A. Rossati, O. Bargiacchi, V. Kroumova, M. Zaramella, A. Caputo, P. L. Garavelli, Climate, environment and transmission of malaria. Infez. Med. 24, 93\u2013104 (2016).","journal-title":"Infez. Med."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513137"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30844-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cois.2019.12.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1025-y"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(58)90036-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959832"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1990.tb00990.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1988.tb00215.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005041"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.05.004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.11.003"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02646-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.4049\/jimmunol.139.12.4213","article-title":"The 230-kDa gamete surface protein of Plasmodium falciparum is also a target for transmission-blocking antibodies","volume":"139","author":"Quakyi I. A.","year":"1987","unstructured":"I. A. Quakyi, R. Carter, J. Rener, N. Kumar, M. F. Good, L. H. Miller, The 230-kDa gamete surface protein of Plasmodium falciparum is also a target for transmission-blocking antibodies. J. Immunol. 139, 4213\u20134217 (1987).","journal-title":"J. Immunol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.05.007"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120692"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0121-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1276833"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav3963"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00644-15"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01056-13"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.64.9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.07.001"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002636"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163144"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.08.033"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146221"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-0196-3"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix442"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057909"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2018.07.009"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02780"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02931"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57384-w"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501858102"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm076"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp033"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(95)00073-A"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.12.001"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01331.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3519"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30344-X"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/333074a0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.5.1460"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00511.x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05288-11"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.03.007"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182015001341"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01256"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.11.072"},{"key":"e_1_3_2_54_2","unstructured":"Radbound University The PATH Malaria Vaccine Initiative (2020) https:\/\/ClinicalTrials.gov\/show\/NCT04238689."},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.33073\/pjm-2015-001"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29969-4"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01236-06"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00525-08"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00964-10"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis645"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.3791\/61426"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.06.066"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.abg2112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abg2112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T16:55:12Z","timestamp":1705424112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abg2112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":62,"journal-issue":{"issue":"597","published-print":{"date-parts":[[2021,6,9]]}},"alternative-id":["10.1126\/scitranslmed.abg2112"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abg2112","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"article-number":"eabg2112"}}