{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:52:06Z","timestamp":1784872326080,"version":"3.55.0"},"reference-count":75,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"592","funder":[{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["WT101766\/Z\/13\/Z"],"award-info":[{"award-number":["WT101766\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["WT207511\/Z\/17\/Z"],"award-info":[{"award-number":["WT207511\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR_N007727_1"],"award-info":[{"award-number":["MR_N007727_1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SGL021\\1045"],"award-info":[{"award-number":["SGL021\\1045"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018942","name":"Centro Singular de Investigaci\u00f3n de Galicia","doi-asserted-by":"publisher","award":["WT101766\/Z\/13\/Z"],"award-info":[{"award-number":["WT101766\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/501100018942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018942","name":"Centro Singular de Investigaci\u00f3n de Galicia","doi-asserted-by":"publisher","award":["207511\/Z\/17\/Z"],"award-info":[{"award-number":["207511\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/501100018942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018942","name":"Centro Singular de Investigaci\u00f3n de Galicia","doi-asserted-by":"publisher","award":["N007727"],"award-info":[{"award-number":["N007727"]}],"id":[{"id":"10.13039\/501100018942","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:p>In vivo IL-17A activity is elevated in active tuberculosis and may be a therapeutic target to attenuate disease-associated immunopathology.<\/jats:p>","DOI":"10.1126\/scitranslmed.abg7673","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T15:13:25Z","timestamp":1620227605000},"source":"Crossref","is-referenced-by-count":61,"title":["Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-0322","authenticated-orcid":true,"given":"Gabriele","family":"Pollara","sequence":"first","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1905-2834","authenticated-orcid":true,"given":"Carolin T.","family":"Turner","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0171-2053","authenticated-orcid":true,"given":"Joshua","family":"Rosenheim","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1027-2862","authenticated-orcid":true,"given":"Aneesh","family":"Chandran","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-7294","authenticated-orcid":true,"given":"Lucy C. K.","family":"Bell","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1959-0488","authenticated-orcid":true,"given":"Ayesha","family":"Khan","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4961-0347","authenticated-orcid":true,"given":"Amit","family":"Patel","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7841-193X","authenticated-orcid":true,"given":"Luis Felipe","family":"Peralta","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-9151","authenticated-orcid":true,"given":"Anna","family":"Folino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-3927","authenticated-orcid":true,"given":"Ayse","family":"Akarca","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4769-7912","authenticated-orcid":true,"given":"Cristina","family":"Venturini","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Baker","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-1710","authenticated-orcid":true,"given":"Simone","family":"Ecker","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-5018","authenticated-orcid":true,"given":"Fabio L. M.","family":"Ricciardolo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-6275","authenticated-orcid":true,"given":"Teresa","family":"Marafioti","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2833-9087","authenticated-orcid":true,"given":"Cesar","family":"Ugarte-Gil","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru."},{"name":"TB Centre, London School of Hygiene &amp; Tropical Medicine, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-0154","authenticated-orcid":true,"given":"David A. J.","family":"Moore","sequence":"additional","affiliation":[{"name":"TB Centre, London School of Hygiene &amp; Tropical Medicine, London, UK."},{"name":"Laboratorio de Investigaci\u00f3n de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-3970","authenticated-orcid":true,"given":"Benjamin M.","family":"Chain","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4342-3161","authenticated-orcid":true,"given":"Gillian S.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-0853","authenticated-orcid":true,"given":"Mahdad","family":"Noursadeghi","sequence":"additional","affiliation":[{"name":"University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095939"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00015411"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30110-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141841"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005469"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00932"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy173"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1361OC"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45666"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903984"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.012"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201304-0803OC"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02209"},{"key":"e_1_3_2_15_2","first-page":"1092","article-title":"Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways","volume":"159","author":"Nograles K. E.","year":"2008","unstructured":"K. E. Nograles, L. C. Zaba, E. Guttman, J. Fuentes-Duculan, M. Suarez-Farinas, I. Cardinale, A. Khatcherian, J. Gonzalez, K. C. Pierson, T. R. White, C. Pensabene, I. Coats, I. Novitskaya, M. A. Lowes, J. G. Krueger, Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br. J. Dermatol. 159, 1092\u20131102 (2008).","journal-title":"Br. J. Dermatol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034594"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.97"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100265"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.10.007"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110919"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu641"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169271"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.041"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4987"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-015-0226-9"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301737"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5013"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000079"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0647"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis499"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024290"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.12.010"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.031"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2457"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049408"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101896"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.004"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1449"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004099"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903332"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137858"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1276-2"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92973"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24444"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.86"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12710"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0026-3"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep40666"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.590"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf3861"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.3.1962"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1463OC"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0580-3"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0909-6"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2011.06.009"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.062"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00298"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.005"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002378"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200573"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep40984"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13489"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004426"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47013"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09447"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaw2262"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01252"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4662"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01571-8"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01157"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136242"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7563.1"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.034"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12429"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.abg7673","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abg7673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:14:18Z","timestamp":1705407258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abg7673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":75,"journal-issue":{"issue":"592","published-print":{"date-parts":[[2021,5,5]]}},"alternative-id":["10.1126\/scitranslmed.abg7673"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abg7673","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/516690","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]},"article-number":"eabg7673"}}