{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:39:51Z","timestamp":1792132791800,"version":"4.4.0"},"reference-count":102,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"620","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2021,11,17]]},"abstract":"<jats:p>Lung epithelial and endothelial cell damage and defective lung tissue repair contribute to fatal COVID-19.<\/jats:p>","DOI":"10.1126\/scitranslmed.abj7790","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T22:50:55Z","timestamp":1634251855000},"source":"Crossref","is-referenced-by-count":224,"title":["Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-9490","authenticated-orcid":true,"given":"Felice","family":"D\u2019Agnillo","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathie-Anne","family":"Walters","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Xiao","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-Mei","family":"Sheng","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5955-5391","authenticated-orcid":true,"given":"Kelsey","family":"Scherler","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-8127","authenticated-orcid":true,"given":"Jaekeun","family":"Park","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Gygli","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8743-7189","authenticated-orcid":true,"given":"Luz Angela","family":"Rosas","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-8330","authenticated-orcid":true,"given":"Kaitlyn","family":"Sadtler","sequence":"additional","affiliation":[{"name":"Section on Immunoengineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4848-2067","authenticated-orcid":true,"given":"Heather","family":"Kalish","sequence":"additional","affiliation":[{"name":"Bioengineering and Physical Sciences Shared Resource, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-6271","authenticated-orcid":true,"suffix":"III","given":"Charles A.","family":"Blatti","sequence":"additional","affiliation":[{"name":"National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0753-5716","authenticated-orcid":true,"given":"Ruoqing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Illinois at Urbana-Champaign, Urbana, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3533-0010","authenticated-orcid":true,"given":"Lisa","family":"Gatzke","sequence":"additional","affiliation":[{"name":"National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-1915","authenticated-orcid":true,"given":"Colleen","family":"Bushell","sequence":"additional","affiliation":[{"name":"National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6393-5178","authenticated-orcid":true,"given":"Matthew J.","family":"Memoli","sequence":"additional","affiliation":[{"name":"Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"O\u2019Day","sequence":"additional","affiliation":[{"name":"Saint John\u2019s Cancer Institute, Santa Monica, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-7924","authenticated-orcid":true,"given":"Trevan D.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Saint John\u2019s Cancer Institute, Santa Monica, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terese C.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Saint John\u2019s Cancer Institute, Santa Monica, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, USC Keck School of Medicine, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Christian","family":"Cash","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, USC Keck School of Medicine, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-8429","authenticated-orcid":true,"given":"Matthew E.","family":"Powers","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, USC Keck School of Medicine, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-9429","authenticated-orcid":true,"given":"Grant E.","family":"O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly J.","family":"Butnor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-022X","authenticated-orcid":true,"given":"Amy V.","family":"Rapkiewicz","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University Long Island School of Medicine, Mineola, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Travis","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7681-2713","authenticated-orcid":true,"given":"Scott P.","family":"Layne","sequence":"additional","affiliation":[{"name":"Saint John\u2019s Cancer Institute, Santa Monica, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-7101","authenticated-orcid":true,"given":"John C.","family":"Kash","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-7228","authenticated-orcid":true,"given":"Jeffery K.","family":"Taubenberger","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106239"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03053-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0603-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12839"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14201"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04182-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X20932640"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00661-1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00586-4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2020.115094"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-5958"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1985"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124061"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4161\/21688370.2014.974448"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0541RT"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/573210"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1152"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa131"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.10402"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03065-y"},{"key":"e_1_3_3_22_2","article-title":"An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility","author":"Wang L.","year":"2020","unstructured":"L. Wang, T. J. Balmat, A. L. Antonia, F. J. Constantine, R. Henao, T. W. Burke, A. Ingham, M. T. McClain, E. L. Tsalik, E. R. Ko, G. S. Ginsburg, M. R. De Long, X. Shen, C. W. Woods, E. R. Hauser, D. C. Ko, An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.medRxiv, 2020.12.20.20248572 , (2020).","journal-title":"medRxiv"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd4570"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa224"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13525"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc5881"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd2321"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9030243"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906850106"},{"key":"e_1_3_3_30_2","first-page":"1600","article-title":"FGFR2 is required for airway basal cell self-renewal and terminal differentiation","volume":"144","author":"Balasooriya G. I.","year":"2017","unstructured":"G. I. Balasooriya, M. Goschorska, E. Piddini, E. L. Rawlins, FGFR2 is required for airway basal cell self-renewal and terminal differentiation. Development 144, 1600\u20131606 (2017).","journal-title":"Development"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.039"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0184OC"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.006031"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.165"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-018-0184-8"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18854-2"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201411-507FR"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep31798"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.213"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00334-0"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.07.012"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00203.2004"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00172-11"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8829674"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.08.009"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141374"},{"key":"e_1_3_3_47_2","first-page":"e138999","article-title":"Neutrophil extracellular traps in COVID-19","volume":"5","author":"Zuo Y.","year":"2020","unstructured":"Y. Zuo, S. Yalavarthi, H. Shi, K. Gockman, M. Zuo, J. A. Madison, C. N. Blair, A. Weber, B. J. Barnes, M. Egeblad, R. J. Woods, Y. Kanthi, J. S. Knight, Neutrophil extracellular traps in COVID-19. JCI Insight 5, e138999 (2020).","journal-title":"JCI Insight"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.063305"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.11.7368"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.105981"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30225-3"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30582-X"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30086-4"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06975-7"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01217-2020"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05275-1"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314514"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.09.019"},{"key":"e_1_3_3_59_2","first-page":"1580","article-title":"Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients","author":"Zuo Y.","year":"2020","unstructured":"Y. Zuo, M. Warnock, A. Harbaugh, S. Yalavarthi, K. Gockman, M. Zuo, J. A. Madison, J. S. Knight, Y. Kanthi, D. A. Lawrence, Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients. medRxiv , 1580 (2020).","journal-title":"medRxiv"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000242905.41404.68"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.11.013"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.015"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.12.014"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13237"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13927"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309451"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.08.008"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02895-6"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30310-7"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.11.10003"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050436"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2020.12.051"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2021.3075299"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706736"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14540"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.10.014"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26038"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.11330"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00254"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01603-w"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12939"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118588"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijri.IJRI_469_16"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-020-0084-5"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-020-00491-y"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12357"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006520"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.08.035"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12372"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.12.052"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02367-2016"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201810234"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-8592(97)80032-X"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150181505"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp373"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129684.111"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp120"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1891-0"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abj7790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:06:35Z","timestamp":1705410395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abj7790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,17]]},"references-count":102,"journal-issue":{"issue":"620","published-print":{"date-parts":[[2021,11,17]]}},"alternative-id":["10.1126\/scitranslmed.abj7790"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abj7790","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,17]]},"article-number":"eabj7790"}}