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To address this unmet need, inspired by molecular gastronomy techniques, we have developed a family of gas-entrapping materials (GEMs) for delivery of CO to the GI tract. We show highly tunable and potent delivery of CO, achieving clinically relevant CO concentrations in vivo in rodent and swine models. To support the potential range of applications of foam GEMs, we evaluated the system in three distinct disease models. We show that a GEM containing CO dose-dependently reduced acetaminophen-induced hepatocellular injury, dampened colitis-associated inflammation and oxidative tissue injury, and mitigated radiation-induced gut epithelial damage in rodents. Collectively, foam GEMs have potential paradigm-shifting implications for the safe therapeutic use of CO across a range of indications.<\/jats:p>","DOI":"10.1126\/scitranslmed.abl4135","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:53:46Z","timestamp":1656525226000},"source":"Crossref","is-referenced-by-count":83,"title":["Delivery of therapeutic carbon monoxide by gas-entrapping materials"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-2866","authenticated-orcid":true,"given":"James D.","family":"Byrne","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"David H. 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