{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:30:04Z","timestamp":1792629004197,"version":"4.5.0"},"reference-count":88,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"640","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,4,13]]},"abstract":"<jats:p>\n            In chronic inflammatory diseases of the central nervous system (CNS), immune cells persisting behind the blood-brain barrier are supposed to promulgate local tissue destruction. The drivers of such compartmentalized inflammation remain unclear, but tissue-resident memory T cells (T\n            <jats:sub>RM<\/jats:sub>\n            ) represent a potentially important cellular player in this process. Here, we investigated whether resting CD8\n            <jats:sup>+<\/jats:sup>\n            T\n            <jats:sub>RM<\/jats:sub>\n            persisting after cleared infection with attenuated lymphocytic choriomeningitis virus (LCMV) can initiate immune responses directed against cognate self-antigen in the CNS. We demonstrated that time-delayed conditional expression of the LCMV glycoprotein as neo-self-antigen by glia cells reactivated CD8\n            <jats:sup>+<\/jats:sup>\n            T\n            <jats:sub>RM<\/jats:sub>\n            . Subsequently, CD8\n            <jats:sup>+<\/jats:sup>\n            T\n            <jats:sub>RM<\/jats:sub>\n            expanded and initiated CNS inflammation and immunopathology in an organ-autonomous manner independently of circulating CD8\n            <jats:sup>+<\/jats:sup>\n            T cells. However, in the absence of CD4\n            <jats:sup>+<\/jats:sup>\n            T cells, TCF-1\n            <jats:sup>+<\/jats:sup>\n            CD8\n            <jats:sup>+<\/jats:sup>\n            T\n            <jats:sub>RM<\/jats:sub>\n            failed to expand and differentiate into terminal effectors. Similarly, in human demyelinating CNS autoimmune lesions, we found CD8\n            <jats:sup>+<\/jats:sup>\n            T cells expressing TCF-1 that predominantly exhibited a T\n            <jats:sub>RM<\/jats:sub>\n            -like phenotype. Together, our study provides evidence for CD8\n            <jats:sup>+<\/jats:sup>\n            T\n            <jats:sub>RM<\/jats:sub>\n            -driven CNS immunopathology and sheds light on why inflammatory processes may evade current immunomodulatory treatments in chronic autoimmune CNS conditions.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.abl6058","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T17:56:07Z","timestamp":1649872567000},"source":"Crossref","is-referenced-by-count":79,"title":["Tissue-resident memory CD8\n            <sup>+<\/sup>\n            T cells cooperate with CD4\n            <sup>+<\/sup>\n            T cells to drive compartmentalized immunopathology in the CNS"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1061-6071","authenticated-orcid":true,"given":"Ilena","family":"Vincenti","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, University 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Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Lemeille","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Nunez","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-2733","authenticated-orcid":true,"given":"Mario","family":"Kreutzfeldt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."},{"name":"Division of Clinical Pathology, Geneva University Hospital, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogna","family":"Klimek","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-0215","authenticated-orcid":true,"given":"Giovanni","family":"Di Liberto","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-9069","authenticated-orcid":true,"given":"Kristof","family":"Egervari","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."},{"name":"Division of Clinical Pathology, Geneva University Hospital, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Piccinno","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazal","family":"Shammas","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mariotte","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fonta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-5857","authenticated-orcid":true,"given":"Nicolas","family":"Liaudet","sequence":"additional","affiliation":[{"name":"Bioimaging core facility, University of Geneva, 1211 Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Shlesinger","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rita","family":"Liuzzi","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, University of Geneva, 1211 Geneva, 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