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Furthermore, responses were equally effective against most SARS-CoV-2 variants of concern (VOCs) and some were highly effective against Omicron. This result contrasts with human infection or many two-shot vaccination protocols where responses were typically more SARS-CoV-2 specific and where VOCs were less well neutralized. Structural studies showed that cloned macaque neutralizing antibodies, particularly using a given heavy chain germline gene, recognized a relatively conserved region proximal to the angiotensin converting enzyme 2 receptor binding site (RBS), whereas many frequently elicited human neutralizing antibodies targeted more variable epitopes overlapping the RBS. B cell repertoire differences between humans and macaques appeared to influence the vaccine response. The macaque neutralizing antibodies identified a pan-SARS\u2013related virus epitope region less well targeted by human antibodies that could be exploited in rational vaccine design.<\/jats:p>","DOI":"10.1126\/scitranslmed.abl9605","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T13:58:13Z","timestamp":1660139893000},"source":"Crossref","is-referenced-by-count":23,"title":["Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-3516","authenticated-orcid":true,"given":"Wan-ting","family":"He","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"Consortium for HIV\/AIDS Vaccine Development (CHAVD), The Scripps 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