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Children protected from symptomatic infections had more anti-envelope (E) and anti\u2013nonstructural protein 1 (NS1) total immunoglobulin G (IgG), IgG4, and greater Fc effector functions than those with symptoms. Fc effector functions were also associated with protection from hemorrhagic manifestations in the pre-symptomatic group. Furthermore, in vitro virological assays using these plasma samples revealed that protection mediated by antibody-dependent complement deposition was associated with both lysis of virions and DENV-infected cells. These data suggest that E- and NS1-specific Fc functions may serve as correlates of protection, which can be potentially applied toward the design and evaluation of dengue vaccines.<\/jats:p>","DOI":"10.1126\/scitranslmed.abm3151","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:53:46Z","timestamp":1656525226000},"source":"Crossref","is-referenced-by-count":72,"title":["Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4392-4206","authenticated-orcid":true,"suffix":"Jr.","given":"Antonio G.","family":"Dias","sequence":"first","affiliation":[{"name":"Division of Infectious Disease and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, 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