{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:14:50Z","timestamp":1791695690548,"version":"4.3.4"},"reference-count":123,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"641","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,4,20]]},"abstract":"<jats:p>Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds. Synthetic biomaterials are less expensive to manufacture than biologic dressings and can achieve a broader range of physiochemical properties, but opportunities remain to tailor these materials for ideal host immune and regenerative responses. Polyesters are a well-established class of synthetic biomaterials; however, acidic degradation products released by their hydrolysis can cause poorly controlled autocatalytic degradation. Here, we systemically explored reactive oxygen species (ROS)\u2013degradable polythioketal (PTK) urethane (UR) foams with varied hydrophilicity for skin wound healing. The most hydrophilic PTK-UR variant, with seven ethylene glycol (EG7) repeats flanking each side of a thioketal bond, exhibited the highest ROS reactivity and promoted optimal tissue infiltration, extracellular matrix (ECM) deposition, and reepithelialization in porcine skin wounds. EG7 induced lower foreign body response, greater recruitment of regenerative immune cell populations, and resolution of type 1 inflammation compared to more hydrophobic PTK-UR scaffolds. Porcine wounds treated with EG7 PTK-UR foams had greater ECM production, vascularization, and resolution of proinflammatory immune cells compared to polyester UR foam\u2013based NovoSorb Biodegradable Temporizing Matrix (BTM)\u2013treated wounds and greater early vascular perfusion and similar wound resurfacing relative to clinical gold standard Integra Bilayer Wound Matrix (BWM). In a porcine ischemic flap excisional wound model, EG7 PTK-UR treatment led to higher wound healing scores driven by lower inflammation and higher reepithelialization compared to NovoSorb BTM. PTK-UR foams warrant further investigation as synthetic biomaterials for wound healing applications.<\/jats:p>","DOI":"10.1126\/scitranslmed.abm6586","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T13:52:41Z","timestamp":1650462761000},"source":"Crossref","is-referenced-by-count":138,"title":["Reactive oxygen species\u2013degradable polythioketal urethane foam dressings to promote porcine skin wound repair"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-301X","authenticated-orcid":true,"given":"Prarthana","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-176X","authenticated-orcid":true,"given":"Joshua T.","family":"McCune","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8331-7665","authenticated-orcid":true,"given":"Alonda C.","family":"Pollins","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-1605","authenticated-orcid":true,"given":"Matthew A.","family":"Cottam","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan R.","family":"Dollinger","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlisle R.","family":"DeJulius","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-3454","authenticated-orcid":true,"given":"Mukesh K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-368X","authenticated-orcid":true,"given":"Richard","family":"D\u2019Arcy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-4246","authenticated-orcid":true,"given":"Juan M.","family":"Colazo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9022-2410","authenticated-orcid":true,"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2616-4826","authenticated-orcid":true,"given":"Mariah G.","family":"Bezold","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1681-3818","authenticated-orcid":true,"given":"John R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5221-898X","authenticated-orcid":true,"given":"Nancy L.","family":"Cardwell","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8782-3565","authenticated-orcid":true,"given":"Jeffrey M.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-5687","authenticated-orcid":true,"given":"Callie M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Vanderbilt Burn Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-6255","authenticated-orcid":true,"given":"Adrian","family":"Barbul","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA."},{"name":"Department of Surgery, Veterans Administration Medical Center, Nashville, TN 37212, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa H.","family":"Hasty","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-8058","authenticated-orcid":true,"given":"Scott A.","family":"Guelcher","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."},{"name":"Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-0620","authenticated-orcid":true,"given":"Craig L.","family":"Duvall","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2019.0946"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe4839"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12051"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12404"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000416006.55218.d0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2000.00068.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5149"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00501-08"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.12426"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700897"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7031899"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12357"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.01.042"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2017.0477"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000006609"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau6210"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14000-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.006"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40204-018-0083-4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3181abffca"},{"key":"e_1_3_3_24_2","first-page":"e1614","article-title":"Comparison of a fully synthetic electrospun matrix to a bi-layered xenograft in healing full thickness cutaneous wounds in a porcine model","volume":"9","author":"MacEwan M. R.","year":"2017","unstructured":"M. R. MacEwan, S. MacEwan, A. P. Wright, T. R. Kovacs, J. Batts, L. Zhang, Comparison of a fully synthetic electrospun matrix to a bi-layered xenograft in healing full thickness cutaneous wounds in a porcine model. Cureus 9, e1614 (2017).","journal-title":"Cureus"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/CWCMR.S50832"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33670"},{"key":"e_1_3_3_27_2","first-page":"163","article-title":"In situ foamable, degradable polyurethane as biomaterial for soft tissue repair","volume":"78","author":"Laube T.","year":"2017","unstructured":"T. Laube, J. Weisser, S. Berger, S. Borner, S. Bischoff, H. Schubert, M. Gajda, R. Brauer, M. Schnabelrauch, In situ foamable, degradable polyurethane as biomaterial for soft tissue repair. Korean J. Couns. Psychother. 78, 163\u2013174 (2017).","journal-title":"Korean J. Couns. Psychother."},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.08.026"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2014.965997"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201303520"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9618-z"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.8b00424"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.301"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201800699"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.026"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2017.0202"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120377"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.08.108"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2580"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2859"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600820"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201209633"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0169-1"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13468"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2020.100271"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0933-0"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200504"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00743"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbw041"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/10590500902885684"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.034"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2007.0264"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.06.019"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0473"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.2008.951194"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9272"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2012.0435"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0608"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax3799"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat6280"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4866"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba0754"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b09900"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.09.024"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3181"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069639"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.05.107"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aax4783"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar2971"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0436"},{"key":"e_1_3_3_72_2","first-page":"143","article-title":"The biological functions of beta3 integrins","volume":"50","author":"Switala-Jelen K.","year":"2004","unstructured":"K. Switala-Jelen, K. Dabrowska, A. Opolski, L. Lipinska, M. Nowaczyk, A. Gorski, The biological functions of beta3 integrins. Folia Biol (Praha) 50, 143\u2013152 (2004).","journal-title":"Folia Biol (Praha)"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3810"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0581"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276722"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90140-5"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00410.x"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.006"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133008"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai8132"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.90"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-00844-w"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2018-0031"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.2147\/ciia.2007.2.1.93"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup9.S14"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2013.0452"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8348-5"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.12406.x"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2003.11304.x"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.06.004"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311401"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12557"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34104"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.025"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201200502"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286872"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm848"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-653"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20191"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800675"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.04.009"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1012544"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4290"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.08.010"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162124199"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.04.002"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.06.006"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/193293a0"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000061"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri978"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3582"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.90362.2008"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH654>3.0.CO;2-S"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.108.3.985"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.1.147"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irz179"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.182"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax6601"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001941"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2003.12.023"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.03.008"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2012.09.019"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119726"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abm6586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:20:12Z","timestamp":1705407612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abm6586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":123,"journal-issue":{"issue":"641","published-print":{"date-parts":[[2022,4,20]]}},"alternative-id":["10.1126\/scitranslmed.abm6586"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abm6586","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]},"article-number":"eabm6586"}}