{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:27:32Z","timestamp":1793413652691,"version":"4.5.0"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"703","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:p>\n                    Depression associated with traumatic brain injury (TBI) is believed to be clinically distinct from primary major depressive disorder (MDD) and may be less responsive to conventional treatments. Brain connectivity differences between the dorsal attention network (DAN), default mode network (DMN), and subgenual cingulate have been implicated in TBI and MDD. To characterize these distinctions, we applied precision functional mapping of brain network connectivity to resting-state functional magnetic resonance imaging data from five published patient cohorts, four discovery cohorts (\n                    <jats:italic>n<\/jats:italic>\n                    = 93), and one replication cohort (\n                    <jats:italic>n<\/jats:italic>\n                    = 180). We identified a distinct brain connectivity profile in TBI-associated depression that was independent of TBI, MDD, posttraumatic stress disorder (PTSD), depression severity, and cohort. TBI-associated depression was independently associated with decreased DAN\u2013subgenual cingulate connectivity, increased DAN-DMN connectivity, and the combined effect of both. This effect was stronger when using precision functional mapping relative to group-level network maps. Our results support the possibility of a physiologically distinct \u201cTBI affective syndrome,\u201d which may benefit from individualized neuromodulation approaches to target its distinct neural circuitry.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.abn0441","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:58:13Z","timestamp":1688565493000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":53,"title":["Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-9289","authenticated-orcid":true,"given":"Shan H.","family":"Siddiqi","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA."},{"name":"Center for Brain Circuit Therapeutics, Brigham and Women\u2019s Hospital, Boston, MA, USA."},{"name":"Department of Psychiatry, Washington University School of Medicine, St.\u00a0Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Kandala","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Washington University School of Medicine, St.\u00a0Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-1713","authenticated-orcid":true,"given":"Carl D.","family":"Hacker","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Washington University School of Medicine, St.\u00a0Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-6334","authenticated-orcid":true,"given":"Heather","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Duke University School of Medicine and Durham VA Medical Center, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Leuthardt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Washington University School of Medicine, St.\u00a0Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St.\u00a0Louis, MO, USA."},{"name":"Department of Neuroscience, University of Padua, Padua, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-6969","authenticated-orcid":true,"given":"Rajendra A.","family":"Morey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Duke University School of Medicine and Durham VA Medical Center, Durham, NC, 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