{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:16:50Z","timestamp":1792682210644,"version":"4.5.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"654","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,7,20]]},"abstract":"<jats:p>\n                    Severe malaria caused by\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    is difficult to diagnose accurately in children in high-transmission settings. Using data from 2649 pediatric and adult patients enrolled in four studies of severe illness in three countries (Bangladesh, Kenya, and Uganda), we fitted Bayesian latent class models using two diagnostic markers: the platelet count and the plasma concentration of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    histidine-rich protein 2 (\n                    <jats:italic>Pf<\/jats:italic>\n                    HRP2). In severely ill patients with clinical features consistent with severe malaria, the combination of a platelet count of \u2264150,000\/\u03bcl and a plasma\n                    <jats:italic>Pf<\/jats:italic>\n                    HRP2 concentration of \u22651000 ng\/ml had an estimated sensitivity of 74% and specificity of 93% in identifying severe falciparum malaria. Compared with misdiagnosed children, pediatric patients with true severe malaria had higher parasite densities, lower hematocrits, lower rates of invasive bacterial disease, and a lower prevalence of both sickle cell trait and sickle cell anemia. We estimate that one-third of the children enrolled into clinical studies of severe malaria in high-transmission settings in Africa had another cause of their severe illness.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.abn5040","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T13:59:46Z","timestamp":1658325586000},"source":"Crossref","is-referenced-by-count":44,"title":["Improving the diagnosis of severe malaria in African children using platelet counts and plasma\n                    <i>Pf<\/i>\n                    HRP2 concentrations"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-0325","authenticated-orcid":true,"given":"James A.","family":"Watson","sequence":"first","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1746-7873","authenticated-orcid":true,"given":"Sophie","family":"Uyoga","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9293-0181","authenticated-orcid":true,"given":"Perpetual","family":"Wanjiku","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-7521","authenticated-orcid":true,"given":"Johnstone","family":"Makale","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5984-7690","authenticated-orcid":true,"given":"Gideon M.","family":"Nyutu","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6585-2074","authenticated-orcid":true,"given":"Neema","family":"Mturi","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2928-3580","authenticated-orcid":true,"given":"Elizabeth C.","family":"George","sequence":"additional","affiliation":[{"name":"Medical Research Council Clinical Trials Unit, University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-7165","authenticated-orcid":true,"given":"Charles J.","family":"Woodrow","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-1171","authenticated-orcid":true,"given":"Nicholas P. J.","family":"Day","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-7549","authenticated-orcid":true,"given":"Philip","family":"Bejon","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK."},{"name":"KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert O.","family":"Opoka","sequence":"additional","affiliation":[{"name":"Makerere University, Department of Paediatrics and Child Health, Kampala, Uganda."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-2395","authenticated-orcid":true,"given":"Arjen M.","family":"Dondorp","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-1411","authenticated-orcid":true,"given":"Chandy C.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Indiana University, Indiana, IN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Maitland","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya."},{"name":"Institute of Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-2382","authenticated-orcid":true,"given":"Thomas N.","family":"Williams","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Coast, Kilifi 80108, Kenya."},{"name":"Institute of Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-1978","authenticated-orcid":true,"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand."},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12313_2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit116"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm986"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040267"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69698"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-018-0392-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-849307"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03904.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0614"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0324-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000349"},{"key":"e_1_3_3_13_2","first-page":"181","article-title":"Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13","volume":"103","author":"L\u00f6wenberg E. 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