{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:25:33Z","timestamp":1793330733743,"version":"4.5.0"},"reference-count":81,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"671","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,11,16]]},"abstract":"<jats:p>\n                    Not all patients with cancer and severe neutropenia develop fever, and the fecal microbiome may play a role. In a single-center study of patients undergoing hematopoietic cell transplant (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0119), the fecal microbiome was characterized at onset of severe neutropenia. A total of 63 patients (53%) developed a subsequent fever, and their fecal microbiome displayed increased relative abundances of\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    , a species of mucin-degrading bacteria (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.006, corrected for multiple comparisons). Two therapies that induce neutropenia, irradiation and melphalan, similarly expanded\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    and additionally thinned the colonic mucus layer in mice. Caloric restriction of unirradiated mice also expanded\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    and thinned the colonic mucus layer. Antibiotic treatment to eradicate\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    before caloric restriction preserved colonic mucus, whereas\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    reintroduction restored mucus thinning. Caloric restriction of unirradiated mice raised colonic luminal pH and reduced acetate, propionate, and butyrate. Culturing\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    in vitro with propionate reduced utilization of mucin as well as of fucose. Treating irradiated mice with an antibiotic targeting\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    or propionate preserved the mucus layer, suppressed translocation of flagellin, reduced inflammatory cytokines in the colon, and improved thermoregulation. These results suggest that diet, metabolites, and colonic mucus link the microbiome to neutropenic fever and may guide future microbiome-based preventive strategies.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.abo3445","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T13:58:11Z","timestamp":1668607091000},"source":"Crossref","is-referenced-by-count":59,"title":["Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-0493","authenticated-orcid":true,"given":"Zaker I.","family":"Schwabkey","sequence":"first","affiliation":[{"name":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0546-8422","authenticated-orcid":true,"given":"Diana H.","family":"Wiesnoski","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-1705","authenticated-orcid":true,"given":"Chia-Chi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bin","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-2109","authenticated-orcid":true,"given":"Dung","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, The 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The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4824-8844","authenticated-orcid":true,"given":"Eiko","family":"Hayase","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette C.","family":"Frenk Oquendo","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, 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