{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:33:32Z","timestamp":1793309612138,"version":"4.5.0"},"reference-count":80,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"650","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,6,22]]},"abstract":"<jats:p>\n                    Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with nonalcoholic fatty liver disease (NAFLD). In cohorts of 409 patients with NAFLD from multiple global regions, we defined and validated hepatic transcriptome and serum secretome signatures predictive of long-term HCC risk in patients with NAFLD. A 133-gene signature, prognostic liver signature (PLS)\u2013NAFLD, predicted incident HCC over up to 15 years of longitudinal observation. High-risk PLS-NAFLD was associated with IDO1\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells and dysfunctional CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in fibrotic portal tracts along with impaired metabolic regulators. PLS-NAFLD was validated in independent cohorts of patients with NAFLD who were HCC na\u00efve (HCC incidence rates at 15 years were 22.7 and 0% in high- and low-risk patients, respectively) or HCC experienced (de novo HCC recurrence rates at 5 years were 71.8 and 42.9% in high- and low-risk patients, respectively). PLS-NAFLD was bioinformatically translated into a four-protein secretome signature, PLSec-NAFLD, which was validated in an independent cohort of HCC-na\u00efve patients with NAFLD and cirrhosis (HCC incidence rates at 15 years were 37.6 and 0% in high- and low-risk patients, respectively). Combination of PLSec-NAFLD with our previously defined etiology-agnostic PLSec-AFP yielded improved HCC risk stratification. PLS-NAFLD was modified by bariatric surgery, lipophilic statin, and IDO1 inhibitor, suggesting that the signature can be used for drug discovery and as a surrogate end point in HCC chemoprevention clinical trials. Collectively, PLS\/PLSec-NAFLD may enable NAFLD-specific HCC risk prediction and facilitate clinical translation of NAFLD-directed HCC chemoprevention.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.abo4474","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T13:54:53Z","timestamp":1655906093000},"source":"Crossref","is-referenced-by-count":114,"title":["Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4109-3421","authenticated-orcid":true,"given":"Naoto","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."},{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-5078","authenticated-orcid":true,"given":"Naoto","family":"Kubota","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Crouchet","sequence":"additional","affiliation":[{"name":"Inserm, U1110, Institut de Recherche sur les Maladies Virales et H\u00e9patiques, University of Strasbourg and IHU, Pole H\u00e9pato-digestif, Strasbourg University Hospitals, Strasbourg 67000, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvaneswari","family":"Koneru","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-9740","authenticated-orcid":true,"given":"Cesia A.","family":"Marquez","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8101-2374","authenticated-orcid":true,"given":"Arun K.","family":"Jajoriya","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayatri","family":"Panda","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongqi","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-2361","authenticated-orcid":true,"given":"Shijia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Goossens","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva 44041, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-1494","authenticated-orcid":true,"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-7645","authenticated-orcid":true,"given":"Zhenyu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-6453","authenticated-orcid":true,"given":"Sara","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6409-1333","authenticated-orcid":true,"given":"Bachir","family":"Taouli","sequence":"additional","affiliation":[{"name":"Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9113-886X","authenticated-orcid":true,"given":"Myron E.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-6313","authenticated-orcid":true,"given":"Maria Isabel","family":"Fiel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, U.S."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-3971","authenticated-orcid":true,"given":"Amit G.","family":"Singal","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Marrero","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."},{"name":"Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-2898","authenticated-orcid":true,"given":"Austin J.","family":"Fobar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-9933","authenticated-orcid":true,"given":"Neehar D.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-3112","authenticated-orcid":true,"given":"Indu","family":"Raman","sequence":"additional","affiliation":[{"name":"BioCenter Microarray Core Facility, Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"BioCenter Microarray Core Facility, Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Taguri","sequence":"additional","affiliation":[{"name":"Department of Data Science, School of Data Science, Yokohama City University, Yokohama 236-0027, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-945X","authenticated-orcid":true,"given":"Atsushi","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3409-2156","authenticated-orcid":true,"given":"Hiroshi","family":"Aikata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-4629","authenticated-orcid":true,"given":"Takashi","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6973-5094","authenticated-orcid":true,"given":"Hayato","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3021-2517","authenticated-orcid":true,"given":"Ryosuke","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-860X","authenticated-orcid":true,"given":"Masahiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Toranomon Hospital, Tokyo 105-0001, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-4028","authenticated-orcid":true,"given":"Shigeki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo-ichi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-0454","authenticated-orcid":true,"given":"Toru","family":"Beppu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3474-2550","authenticated-orcid":true,"given":"Hideo","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8555, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Toranomon Hospital, Tokyo 105-0001, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-5341","authenticated-orcid":true,"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Collaborative Research Laboratory of Medical Innovation, Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima 734-8551, Japan."},{"name":"RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Baumert","sequence":"additional","affiliation":[{"name":"Inserm, U1110, Institut de Recherche sur les Maladies Virales et H\u00e9patiques, University of Strasbourg and IHU, Pole H\u00e9pato-digestif, Strasbourg University Hospitals, Strasbourg 67000, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-1426","authenticated-orcid":true,"given":"Yujin","family":"Hoshida","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas , TX 75390, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.20324"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29913"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31309"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31845"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029349"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804525"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.021"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307862"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.11.004"},{"key":"e_1_3_3_13_2","first-page":"836","article-title":"A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis","volume":"2","author":"Fujiwara N.","year":"2021","unstructured":"N. Fujiwara, M. Kobayashi, A. J. Fobar, A. Hoshida, C. A. Marquez, B. Koneru, G. Panda, M. Taguri, T. Qian, I. Raman, Q. Z. Li, H. Hoshida, H. Sezaki, H. Kumada, R. Tateishi, T. Yokoo, A. C. Yopp, R. T. Chung, B. C. Fuchs, T. F. Baumert, J. A. Marrero, N. D. Parikh, S. Zhu, A. G. Singal, Y. Hoshida, A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis. Med (N Y) 2, 836\u2013850.e10 (2021).","journal-title":"Med (N Y)"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2017.26"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn326"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.016"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2607"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.10.048"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.07.001"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07338-z"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.10.007"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.053"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02414"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114497"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1373-2"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1631-3"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100278"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03362-0"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03233-8"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31056"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0501"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01344-3"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.01.002"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab043"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0292-x"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2001.00114.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32185"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00014"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00408-y"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.250"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.03.021"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0076-1"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92264"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001347"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-019-0536-1"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25468-9"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.09.014"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba4448"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48746-5"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00122"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp335"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.425"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14968"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020108"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31238"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0506-500"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015543"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.10.010"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29203"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3052"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18186-1"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318918"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14265"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr260"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_3_72_2","unstructured":"G. A. Van der Auwera B. D. O\u2019Connor Genomics in the Cloud: Using Docker GATK and WDL in Terra (O\u2019Reilly Media 2020)."},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.1.308"},{"key":"e_1_3_3_74_2","first-page":"201178","article-title":"Scaling accurate genetic variant discovery to tens of thousands of samples","author":"Poplin R.","year":"2017","unstructured":"R. Poplin, V. Ruano-Rubio, M. A. DePristo, T. J. Fennell, M. O. Carneiro, G. A. Van der Auwera, D. E. Kling, L. D. Gauthier, A. Levy-Moonshine, D. Roazen, Scaling accurate genetic variant discovery to tens of thousands of samples. BioRxiv , 201178 (2017).","journal-title":"BioRxiv"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06318-7"},{"key":"e_1_3_3_76_2","unstructured":"R. A. Fisher Statistical Methods for Research Workers (Oliver and Boyd 1932)."},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.07.004"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.07.047"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.03.019"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.02.041"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0093-0"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abo4474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:51:25Z","timestamp":1705409485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abo4474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,22]]},"references-count":80,"journal-issue":{"issue":"650","published-print":{"date-parts":[[2022,6,22]]}},"alternative-id":["10.1126\/scitranslmed.abo4474"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abo4474","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,22]]},"article-number":"eabo4474"}}