{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:48:39Z","timestamp":1792900119332,"version":"4.5.0"},"reference-count":73,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"671","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,11,16]]},"abstract":"<jats:p>Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications.<\/jats:p>","DOI":"10.1126\/scitranslmed.abo5795","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T18:58:11Z","timestamp":1668625091000},"source":"Crossref","is-referenced-by-count":111,"title":["A persistent neutrophil-associated immune signature characterizes post\u2013COVID-19 pulmonary sequelae"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1316-4891","authenticated-orcid":true,"given":"Peter M.","family":"George","sequence":"first","affiliation":[{"name":"Royal Brompton and Harefield Clinical Group, Guy\u2019s and St.\u00a0Thomas\u2019 NHS Foundation Trust, London SW3 6NR, UK."},{"name":"National Heart and Lung Institute, Imperial College London, London SW3 6LY, 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