{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:30:50Z","timestamp":1761921050518,"version":"3.41.2"},"reference-count":13,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"665","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,10,5]]},"abstract":"<jats:p>Human monoclonal antibodies (mAbs) that target the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) offer a promising approach for the prevention and treatment of coronavirus disease 2019 (COVID-19). Given suboptimal global vaccination rates, waning immunity in vaccinated individuals, and the emergence of SARS-CoV-2 variants of concern, the use of mAbs for COVID-19 prevention may increase and may need to be administered together with vaccines in certain settings. However, it is unknown whether administration of mAbs will affect the immunogenicity of SARS-CoV-2 vaccines. Using an adenovirus vector\u2013based SARS-CoV-2 vaccine, we show that simultaneous administration of the vaccine with SARS-CoV-2 mAbs does not diminish vaccine-induced humoral or cellular immunity in cynomolgus macaques. These results suggest that SARS-CoV-2 mAbs and viral vector-based SARS-CoV-2 vaccines can be administered together without loss of potency of either product. Additional studies will be required to evaluate coadministration of mAbs with other vaccine platforms.<\/jats:p>","DOI":"10.1126\/scitranslmed.abo6160","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T13:58:08Z","timestamp":1657634288000},"source":"Crossref","is-referenced-by-count":7,"title":["A bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaques"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0678-9765","authenticated-orcid":true,"given":"Joseph P.","family":"Nkolola","sequence":"first","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-6623","authenticated-orcid":true,"given":"Jingyou","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-9464","authenticated-orcid":true,"given":"Huahua","family":"Wan","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-0979","authenticated-orcid":true,"given":"Aiquan","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-0539","authenticated-orcid":true,"given":"Katherine","family":"McMahan","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4523-4997","authenticated-orcid":true,"given":"Tochi","family":"Anioke","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-0342","authenticated-orcid":true,"given":"Catherine","family":"Jacob-Dolan","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Powers","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Ye","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7821-5552","authenticated-orcid":true,"given":"Abishek","family":"Chandrashekar","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-9459","authenticated-orcid":true,"given":"Daniel","family":"Sellers","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-3632","authenticated-orcid":true,"given":"Julia","family":"Barrett","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-7273","authenticated-orcid":true,"given":"Yueh-Ming","family":"Loo","sequence":"additional","affiliation":[{"name":"Microbial Sciences, AstraZeneca, Gaithersburg, MD 20878, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-3475","authenticated-orcid":true,"given":"Mark T.","family":"Esser","sequence":"additional","affiliation":[{"name":"Microbial Sciences, AstraZeneca, Gaithersburg, MD 20878, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5230-1532","authenticated-orcid":true,"given":"Robert H.","family":"Carnahan","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA."},{"name":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-1079","authenticated-orcid":true,"suffix":"Jr.","given":"James E.","family":"Crowe","sequence":"additional","affiliation":[{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA."},{"name":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA."},{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5127-4659","authenticated-orcid":true,"given":"Dan H.","family":"Barouch","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."},{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_3_3_3_2","unstructured":"John Hopkins University and Medicine COVID-19 dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU); https:\/\/coronavirus.jhu.edu\/map.html."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-021-01122-8"},{"key":"e_1_3_3_5_2","unstructured":"VIPER Group COVID19 Vaccine Tracker Team COVID19 vaccine tracker; https:\/\/covid19.trackvaccines.org\/."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2548-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abl8124"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109682"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00972-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00974-21"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00044-21"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01678-y"},{"key":"e_1_3_3_13_2","unstructured":"U.S. Food and Drug Administration Emergency use authorization 104 (2022); www.fda.gov\/media\/154704\/download."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-00243-x"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abo6160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:58:02Z","timestamp":1705427882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abo6160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,5]]},"references-count":13,"journal-issue":{"issue":"665","published-print":{"date-parts":[[2022,10,5]]}},"alternative-id":["10.1126\/scitranslmed.abo6160"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abo6160","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"type":"print","value":"1946-6234"},{"type":"electronic","value":"1946-6242"}],"subject":[],"published":{"date-parts":[[2022,10,5]]},"article-number":"eabo6160"}}