{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:33:42Z","timestamp":1793752422482,"version":"4.6.1"},"reference-count":74,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"708","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,8,9]]},"abstract":"<jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating glycolysis. We analyzed mitochondrial gene expression in nasopharyngeal and autopsy tissues from patients with coronavirus disease 2019 (COVID-19). In nasopharyngeal samples with declining viral titers, the virus blocked the transcription of a subset of nuclear DNA (nDNA)\u2013encoded mitochondrial OXPHOS genes, induced the expression of microRNA 2392, activated HIF-1\u03b1 to induce glycolysis, and activated host immune defenses including the integrated stress response. In autopsy tissues from patients with COVID-19, SARS-CoV-2 was no longer present, and mitochondrial gene transcription had recovered in the lungs. However, nDNA mitochondrial gene expression remained suppressed in autopsy tissue from the heart and, to a lesser extent, kidney, and liver, whereas mitochondrial DNA transcription was induced and host-immune defense pathways were activated. During early SARS-CoV-2 infection of hamsters with peak lung viral load, mitochondrial gene expression in the lung was minimally perturbed but was down-regulated in the cerebellum and up-regulated in the striatum even though no SARS-CoV-2 was detected in the brain. During the mid-phase SARS-CoV-2 infection of mice, mitochondrial gene expression was starting to recover in mouse lungs. These data suggest that when the viral titer first peaks, there is a systemic host response followed by viral suppression of mitochondrial gene transcription and induction of glycolysis leading to the deployment of antiviral immune defenses. Even when the virus was cleared and lung mitochondrial function had recovered, mitochondrial function in the heart, kidney, liver, and lymph nodes remained impaired, potentially leading to severe COVID-19 pathology.<\/jats:p>","DOI":"10.1126\/scitranslmed.abq1533","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T17:58:40Z","timestamp":1691603920000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":197,"title":["Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7826","authenticated-orcid":true,"given":"Joseph W.","family":"Guarnieri","sequence":"first","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-3378","authenticated-orcid":true,"given":"Joseph M.","family":"Dybas","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Fazelinia","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1507-9829","authenticated-orcid":true,"given":"Man S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7514-8873","authenticated-orcid":true,"given":"Justin","family":"Frere","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New\u00a0York, NY 10023, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-3115","authenticated-orcid":true,"given":"Yentli","family":"Soto Albrecht","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-2126","authenticated-orcid":true,"given":"Deborah G.","family":"Murdock","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-5451","authenticated-orcid":true,"given":"Alessia","family":"Angelin","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-5864","authenticated-orcid":true,"given":"Larry N.","family":"Singh","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-297X","authenticated-orcid":true,"given":"Sonja M.","family":"Best","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Rocky Mountain Laboratory, National Institute of Allergy and Infectious Disease, NIH, Hamilton, MT 59840, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2035-479X","authenticated-orcid":true,"given":"Marie T.","family":"Lott","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1996-5289","authenticated-orcid":true,"given":"Shiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4984-0567","authenticated-orcid":true,"given":"Henry","family":"Cope","sequence":"additional","affiliation":[{"name":"University of Nottingham, Nottingham, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-4902","authenticated-orcid":true,"given":"Victoria","family":"Zaksas","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"University of Chicago, Chicago, IL 60615, USA."},{"name":"Clever Research Lab, Springfield, IL 62704, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7505-2743","authenticated-orcid":true,"given":"Amanda","family":"Saravia-Butler","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Logyx, LLC, Mountain View, CA 94043, USA."},{"name":"NASA Ames Research Center, Moffett Field, CA 94035, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0663-6216","authenticated-orcid":true,"given":"Cem","family":"Meydan","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Weill Cornell Medicine, New\u00a0York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Foox","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New\u00a0York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Mozsary","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New\u00a0York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-575X","authenticated-orcid":true,"given":"Yaron","family":"Bram","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New\u00a0York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yared","family":"Kidane","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Priebe","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-5767","authenticated-orcid":true,"given":"Mark R.","family":"Emmett","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-8019","authenticated-orcid":true,"given":"Robert","family":"Meller","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Morehouse School of Medicine, Atlanta, GA 30310, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-3994","authenticated-orcid":true,"given":"Sam","family":"Demharter","sequence":"additional","affiliation":[{"name":"DKAbzu ApS, Copenhagen 2150, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-7731","authenticated-orcid":true,"given":"Valdemar","family":"Stentoft-Hansen","sequence":"additional","affiliation":[{"name":"DKAbzu ApS, Copenhagen 2150, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Salvatore","sequence":"additional","affiliation":[{"name":"DKAbzu ApS, Copenhagen 2150, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-7148","authenticated-orcid":true,"given":"Diego","family":"Galeano","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Facultad de Ingenier\u00eda, Universidad Nacional de Asunci\u00f3n, San Lorenzo, Central, Paraguay."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-8557","authenticated-orcid":true,"given":"Francisco J.","family":"Enguita","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Faculdade de Medicina, Universidade de Lisboa, Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, 1649-028 Lisboa, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Grabham","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New\u00a0York, NY 19103, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidia S.","family":"Trovao","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urminder","family":"Singh","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Iowa State University, Ames, IA 50011, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-2920","authenticated-orcid":true,"given":"Jeffrey","family":"Haltom","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Iowa State University, Ames, IA 50011, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Heise","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel J.","family":"Moorman","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria K.","family":"Baxter","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0209-914X","authenticated-orcid":true,"given":"Emily A.","family":"Madden","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon A.","family":"Taft-Benz","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7877-1639","authenticated-orcid":true,"given":"Elizabeth J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wes A.","family":"Sanders","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-6587","authenticated-orcid":true,"given":"Rebekah J.","family":"Dickmander","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-3798","authenticated-orcid":true,"given":"Stephen B.","family":"Baylin","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Johns Hopkins School of Medicine, Baltimore, MD 21287, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-9495","authenticated-orcid":true,"given":"Eve Syrkin","family":"Wurtele","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Iowa State University, Ames, IA 50011, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8263-786X","authenticated-orcid":true,"given":"Pedro M.","family":"Moraes-Vieira","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"University of Campinas, Campinas, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-4610","authenticated-orcid":true,"given":"Deanne","family":"Taylor","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1850-1642","authenticated-orcid":true,"given":"Christopher E.","family":"Mason","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Weill Cornell Medicine, New\u00a0York, NY 10065, USA."},{"name":"New York Genome Center, New\u00a0York, NY 10013, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7382-2783","authenticated-orcid":true,"given":"Jonathan C.","family":"Schisler","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-5995","authenticated-orcid":true,"given":"Robert E.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Weill Cornell Medicine, New\u00a0York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-531X","authenticated-orcid":true,"given":"Afshin","family":"Beheshti","sequence":"additional","affiliation":[{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA."},{"name":"KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-8278","authenticated-orcid":true,"given":"Douglas C.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Center for Mitochondrial and Epigenomic Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA."},{"name":"COVID-19 International Research Team, Medford, MA 02155, USA ."},{"name":"Division of Human Genetics, Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2020.06.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00224.2020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-022-01108-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103722"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.21"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0372-z"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03252-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.11.003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03527-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170098"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.09.002"},{"key":"e_1_3_2_13_2","first-page":"52","article-title":"The complex interaction of mitochondrial genetics and mitochondrial pathways in psychiatric disease","volume":"4","author":"Cuperfain A. B.","year":"2018","unstructured":"A. B.\u00a0Cuperfain, Z. L.\u00a0Zhang, J. L.\u00a0Kennedy, V. F.\u00a0Goncalves, The complex interaction of mitochondrial genetics and mitochondrial pathways in psychiatric disease. Mol. Neuropsychiatry 4, 52\u201369 (2018).","journal-title":"Mol. Neuropsychiatry"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe9403"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2286-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03493-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17488-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108761"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.145027"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2332-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79552-z"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103471"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.07.007"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100159"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109920"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00726-w"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.047"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21903-z"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.164"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01373"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22166-4"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12188"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2076-4"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29479-y"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2078-2"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e13-01-0067"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201702058"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42940"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32733"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.031"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00426.2020"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.08.010"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21361-7"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.016"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1011"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0363-0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0489-5"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00146-4"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100146"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22397-5"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12551"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.07.007"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805056200"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109839"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","unstructured":"J.\u00a0T.\u00a0McDonald F.\u00a0J.\u00a0Enguita D.\u00a0Taylor R.\u00a0J.\u00a0Griffin W.\u00a0Priebe M.\u00a0R.\u00a0Emmett M.\u00a0M.\u00a0Sajadi A.\u00a0D.\u00a0Harris J.\u00a0Clement J.\u00a0M.\u00a0Dybas N.\u00a0Aykin-Burns J.\u00a0W.\u00a0Guarnieri L.\u00a0N.\u00a0Singh P.\u00a0Grabham S.\u00a0B.\u00a0Baylin A.\u00a0Yousey A.\u00a0N.\u00a0Pearson P.\u00a0M.\u00a0Corry A.\u00a0Saravia-Butler T.\u00a0R.\u00a0Aunins S.\u00a0Sharma P.\u00a0Nagpal C.\u00a0Meydan J.\u00a0Foox C.\u00a0Mozsary B.\u00a0Cerqueira V.\u00a0Zaksas U.\u00a0Singh E.\u00a0S.\u00a0Wurtele S.\u00a0V.\u00a0Costes G.\u00a0G.\u00a0Davanzo D.\u00a0Galeano A.\u00a0Paccanaro S.\u00a0L.\u00a0Meinig R.\u00a0S.\u00a0Hagan N.\u00a0M.\u00a0Bowman; UNC COVID- Pathobiology Consortium M.\u00a0C.\u00a0Wolfgang S.\u00a0Altinok N.\u00a0Sapoval T.\u00a0J.\u00a0Treangen P.\u00a0M.\u00a0Moraes-Vieira C.\u00a0Vanderburg D.\u00a0C.\u00a0Wallace J.\u00a0Schisler C.\u00a0E.\u00a0Mason A.\u00a0Chatterjee R.\u00a0Meller A.\u00a0Beheshti The great deceiver: miR-2392's hidden role in driving SARS-CoV-2 infection. bioRxiv 2021.2004.2023.441024 [preprint] (2021). https:\/\/doi.org\/10.1101\/2021.04.23.441024.","DOI":"10.1101\/2021.04.23.441024"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2505"},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","unstructured":"Y. Zhang M.\u00a0S.\u00a0Kim E.\u00a0Nguyen D.\u00a0M.\u00a0Taylor Modeling metabolic variation with single-cell expression data. bioRxiv 2020.01.28.923680 [preprint] (2020). https:\/\/doi.org\/10.1101\/2020.01.28.923680.","DOI":"10.1101\/2020.01.28.923680"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq3059"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.050"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03148-w"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05282-z"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1064293"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.0762"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100522"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109527"},{"key":"e_1_3_2_68_2","doi-asserted-by":"crossref","unstructured":"G. Korotkevich V.\u00a0Sukhov N.\u00a0Budin B.\u00a0Shpak M.\u00a0N.\u00a0Artyomov A.\u00a0Sergushichev Fast gene set enrichment analysis. bioRxiv 060012 (2021). https:\/\/doi.org\/10.1101\/060012","DOI":"10.1101\/060012"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqab049"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1209"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu393"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610772104"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004808"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abq1533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:50:48Z","timestamp":1705427448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abq1533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":74,"journal-issue":{"issue":"708","published-print":{"date-parts":[[2023,8,9]]}},"alternative-id":["10.1126\/scitranslmed.abq1533"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abq1533","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]},"assertion":[{"value":"2022-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eabq1533"}}