{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:03:59Z","timestamp":1787238239554,"version":"build-2736575974"},"reference-count":51,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"686","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,3,8]]},"abstract":"<jats:p>Genetic variants among individuals have been associated with ineffective control of hypertension. Previous work has shown that hypertension has a polygenic nature, and interactions between these loci have been associated with variations in drug response. Rapid detection of multiple genetic loci with high sensitivity and specificity is needed for the effective implementation of personalized medicine for the treatment of hypertension. Here, we used a cationic conjugated polymer (CCP)\u2013based multistep fluorescence resonance energy transfer (MS-FRET) technique to qualitatively analyze DNA genotypes associated with hypertension in the Chinese population. Assessment of 10 genetic loci using this technique successfully identified known hypertensive risk alleles in a retrospective study of whole-blood samples from 150 patients hospitalized with hypertension. We then applied our detection method in a prospective clinical trial of 100 patients with essential hypertension and found that personalized treatment of patients with hypertension based on results from the MS-FRET technique could effectively improve blood pressure control rate (94.0% versus 54.0%) and shorten the time duration to controlling blood pressure (4.06\u00a0\u00b1\u00a02.10 versus 5.82\u00a0\u00b1\u00a01.84 days) as compared with conventional treatment. These results suggest that CCP-based MS-FRET genetic variant detection may assist clinicians in rapid and accurate classification of risk in patients with hypertension and improve treatment outcomes.<\/jats:p>","DOI":"10.1126\/scitranslmed.abq5753","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T13:58:08Z","timestamp":1678283888000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":21,"title":["Sensitive detection of single-nucleotide polymorphisms by conjugated polymers for personalized treatment of hypertension"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-9516","authenticated-orcid":true,"given":"Qi","family":"Shen","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P.\u00a0R.\u00a0China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-891X","authenticated-orcid":true,"given":"Honghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiac Department, Sixth Center of Chinese PLA General Hospital; Cardiac Department, First Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases; Department of Cardiology &amp; National Clinical Research Center of Geriatric Disease; Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, First Center of Chinese PLA General Hospital, Beijing 100141, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-0767","authenticated-orcid":true,"given":"Yiming","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3019-9212","authenticated-orcid":true,"given":"Mingyu","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P.\u00a0R.\u00a0China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9125-617X","authenticated-orcid":true,"given":"Hao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-0513","authenticated-orcid":true,"given":"Zhiwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P.\u00a0R.\u00a0China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cardiac Department, Sixth Center of Chinese PLA General Hospital; Cardiac Department, First Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases; Department of Cardiology &amp; National Clinical Research Center of Geriatric Disease; Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, First Center of Chinese PLA General Hospital, Beijing 100141, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiac Department, Sixth Center of Chinese PLA General Hospital; Cardiac Department, First Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases; Department of Cardiology &amp; National Clinical Research Center of Geriatric Disease; Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, First Center of Chinese PLA General Hospital, Beijing 100141, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8660-2154","authenticated-orcid":true,"given":"Zihao","family":"Fu","sequence":"additional","affiliation":[{"name":"Cardiac Department, Sixth Center of Chinese PLA General Hospital; Cardiac Department, First Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases; Department of Cardiology &amp; National Clinical Research Center of Geriatric Disease; Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, First Center of Chinese PLA General Hospital, Beijing 100141, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3369-6166","authenticated-orcid":true,"given":"Yufei","family":"Di","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P.\u00a0R.\u00a0China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4827-6009","authenticated-orcid":true,"given":"Libing","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3613-3713","authenticated-orcid":true,"given":"Haotian","family":"Bai","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-3096","authenticated-orcid":true,"given":"Fengting","family":"Lv","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-9375","authenticated-orcid":true,"given":"Yundai","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiac Department, Sixth Center of Chinese PLA General Hospital; Cardiac Department, First Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases; Department of Cardiology &amp; National Clinical Research Center of Geriatric Disease; Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, First Center of Chinese PLA General Hospital, Beijing 100141, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5792-5723","authenticated-orcid":true,"given":"Yuqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiac Department, Sixth Center of Chinese PLA General Hospital; Cardiac Department, First Center of Chinese PLA General Hospital, National Key Laboratory of Kidney Diseases; Department of Cardiology &amp; National Clinical Research Center of Geriatric Disease; Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, First Center of Chinese PLA General Hospital, Beijing 100141, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-2535","authenticated-orcid":true,"given":"Shu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China."},{"name":"College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P.\u00a0R.\u00a0China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16080"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.555754"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/275279"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2017.11.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032380"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32478-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S267346"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-004-0005-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13598"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.14"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14240"},{"key":"e_1_3_3_14_2","first-page":"443","article-title":"Using genotyping to predict responses to anti-hypertensive treatment","volume":"26","author":"Kurland L.","year":"2005","unstructured":"L.\u00a0Kurland, L.\u00a0Lind, H.\u00a0Melhus, Using genotyping to predict responses to anti-hypertensive treatment. Trends Pharmacol. Sci. 26, 443\u2013447 (2005).","journal-title":"Trends Pharmacol. Sci."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4173"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15856"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-015-0148-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-006-0070-3"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.06.014"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2013.10.063"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10058"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.11"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5AN01632K"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.244"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.442"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gni017"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2012.12.042"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1603753113"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2209"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.79"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c03218"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac402720g"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/am300830r"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1515\/dmdi-2014-0001"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872019001201527"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-10-RG-009"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2019.107199"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2017.03.003"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2016-0118"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328317cc57"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283385a1c"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13159"},{"key":"e_1_3_3_43_2","first-page":"341","article-title":"Pharmacogenomics and hypertension: Current insights","volume":"12","author":"Oliveira-Paula G. H.","year":"2019","unstructured":"G. H.\u00a0Oliveira-Paula, S. C.\u00a0Pereira, J. E.\u00a0Tanus-Santos, R.\u00a0Lacchini, Pharmacogenomics and hypertension: Current insights. Pharmgenomics Pers. Med. 12, 341\u2013359 (2019).","journal-title":"Pharmgenomics Pers. Med."},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1517\/phgs.5.3.243.29833"},{"key":"e_1_3_3_45_2","first-page":"189","article-title":"Association of CYP3A5 Gene polymorphisms and amlodipine-induced peripheral edema in Chinese han patients with essential hypertension","volume":"14","author":"Liang H.","year":"2021","unstructured":"H.\u00a0Liang, X.\u00a0Zhang, Z.\u00a0Ma, Y.\u00a0Sun, C.\u00a0Shu, Y.\u00a0Zhu, Y.\u00a0Zhang, S.\u00a0Hu, X.\u00a0Fu, L.\u00a0Liu, Association of CYP3A5 Gene polymorphisms and amlodipine-induced peripheral edema in Chinese han patients with essential hypertension. Pharmgenomics Pers. Med. 14, 189\u2013197 (2021).","journal-title":"Pharmgenomics Pers. Med."},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1586\/erc.10.27"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.821"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar9001813"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.04.001"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001521"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.39"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.70"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abq5753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:33:44Z","timestamp":1705412024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abq5753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":51,"journal-issue":{"issue":"686","published-print":{"date-parts":[[2023,3,8]]}},"alternative-id":["10.1126\/scitranslmed.abq5753"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abq5753","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]},"assertion":[{"value":"2022-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eabq5753"}}