{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:21:41Z","timestamp":1786429301052,"version":"build-2736575974"},"reference-count":111,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"695","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,5,10]]},"abstract":"<jats:p>Alterations in the p38 mitogen-activated protein kinases (MAPKs) play an important role in the pathogenesis of dementia with Lewy bodies (DLB) and Parkinson\u2019s disease (PD). Activation of the p38\u03b1 MAPK isoform and mislocalization of the p38\u03b3 MAPK isoform are associated with neuroinflammation and synaptic degeneration in DLB and PD. Therefore, we hypothesized that p38\u03b1 might be associated with neuronal p38\u03b3 distribution and synaptic dysfunction in these diseases. To test this hypothesis, we treated in vitro cellular and in vivo mouse models of DLB\/PD with SKF-86002, a compound that attenuates inflammation by inhibiting p38\u03b1\/\u03b2, and then investigated the effects of this compound on p38\u03b3 and neurodegenerative pathology. We found that inhibition of p38\u03b1 reduced neuroinflammation and ameliorated synaptic, neurodegenerative, and motor behavioral deficits in transgenic mice overexpressing human \u03b1-synuclein. Moreover, treatment with SKF-86002 promoted the redistribution of p38\u03b3 to synapses and reduced the accumulation of \u03b1-synuclein in mice overexpressing human \u03b1-synuclein. Supporting the potential value of targeting p38 in DLB\/PD, we found that SKF-86002 promoted the redistribution of p38\u03b3 in neurons differentiated from iPS cells derived from patients with familial PD (carrying the A53T \u03b1-synuclein mutation) and healthy controls. Treatment with SKF-86002 ameliorated \u03b1-synuclein\u2013induced neurodegeneration in these neurons only when microglia were pretreated with this compound. However, direct treatment of neurons with SKF-86002 did not affect \u03b1-synuclein\u2013induced neurotoxicity, suggesting that SKF-86002 treatment inhibits \u03b1-synuclein\u2013induced neurotoxicity mediated by microglia. These findings provide a mechanistic connection between p38\u03b1 and p38\u03b3 as well as a rationale for targeting this pathway in DLB\/PD.<\/jats:p>","DOI":"10.1126\/scitranslmed.abq6089","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T17:59:48Z","timestamp":1683741588000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":43,"title":["Inhibition of p38\u03b1 MAPK restores neuronal p38\u03b3 MAPK and ameliorates synaptic degeneration in a mouse model of DLB\/PD"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7181-7745","authenticated-orcid":true,"given":"Michiyo","family":"Iba","sequence":"first","affiliation":[{"name":"Laboratory of Neurogenetics, Molecular Neuropathology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-8195","authenticated-orcid":true,"given":"Changyoun","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, Molecular Neuropathology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, Molecular Neuropathology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1336-1951","authenticated-orcid":true,"given":"Marcell","family":"Szabo","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, Molecular Neuropathology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7237-7574","authenticated-orcid":true,"given":"Liam","family":"Horan-Portelance","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, Molecular Neuropathology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9395-3473","authenticated-orcid":true,"given":"Cody J.","family":"Peer","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-5613","authenticated-orcid":true,"given":"William D.","family":"Figg","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xylena","family":"Reed","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-4524","authenticated-orcid":true,"given":"Jinhui","family":"Ding","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, Computational Biology Group, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5155-5335","authenticated-orcid":true,"given":"Seung-Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Neuroscience Research Institute, and Department of Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9245-8278","authenticated-orcid":true,"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-3831","authenticated-orcid":true,"given":"Mark R.","family":"Cookson","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassia","family":"Overk","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf","family":"Wrasidlo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-5569","authenticated-orcid":true,"given":"Eliezer","family":"Masliah","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, Molecular Neuropathology Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."},{"name":"Division of Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3406"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0073-2"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0306-8"},{"key":"e_1_3_4_5_2","unstructured":"N.\u00a0N.\u00a0I.\u00a0o.\u00a0Aging (2021) vol. 2021 https:\/\/www.nia.nih.gov\/health\/what-lewy-body-dementia-causes-symptoms-and-treatments."},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0107-7"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.11.001"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1091-10.2010"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14810"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05958-z"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009313"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101738"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2020.02.001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1395992"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0349-x"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00935-4"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-01926-1"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2019.10.005"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02268-5"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28264"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab103"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01888-0"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00719"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155485"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.05.016"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00286"},{"key":"e_1_3_4_28_2","first-page":"67","article-title":"p38 MAPK and PI3K\/AKT signalling cascades in Parkinson's disease","volume":"4","author":"Jha S. K.","year":"2015","unstructured":"S. K.\u00a0Jha, N. K.\u00a0Jha, R.\u00a0Kar, R. K.\u00a0Ambasta, P.\u00a0Kumar, p38 MAPK and PI3K\/AKT signalling cascades in Parkinson's disease. Int.\u00a0J.\u00a0Mol. Cell Med. 4, 67\u201386 (2015).","journal-title":"Int.\u00a0J.\u00a0Mol. Cell Med."},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0273-5"},{"key":"e_1_3_4_30_2","first-page":"199","article-title":"The p38 MAP kinase family as regulators of proinflammatory cytokine production in degenerative diseases of the CNS","volume":"1","author":"Bachstetter A. D.","year":"2010","unstructured":"A. D.\u00a0Bachstetter, L. J.\u00a0Van Eldik, The p38 MAP kinase family as regulators of proinflammatory cytokine production in degenerative diseases of the CNS. Aging Dis. 1, 199\u2013211 (2010).","journal-title":"Aging Dis."},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/649079"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00322-w"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165624"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00031"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02460-2"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02191-1"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600578"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031628"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00002"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22081287"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0221-y"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.549"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/ml2001455"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1989.0242"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05115.x"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.12.009"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(99)00008-X"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(94)90277-1"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032567"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.14.8389"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.10.011"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.213538"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201502"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/80624"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5407-03.2004"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0624-8"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312868200"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.153122"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13592"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm901297e"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2017"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.03.008"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2008.08.006"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1930-10.2010"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.01.010"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.570586"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1177"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0014-2956.2001.02512.x"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2003.10.025"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(98)00113-0"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.081125"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep43153"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay0399"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.11.013"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-015-0192-0"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.04.008"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327117715901"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10671"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.01.002"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045069"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-011-9271-x"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01178.x"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05310.x"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-125153"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.12.023"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20100503"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.2.335"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.11.011"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.05.006"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1177"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2010.07.006"},{"key":"e_1_3_4_92_2","first-page":"H1857","article-title":"Ischemic preconditioning triggers tyrosine kinase signaling: A potential role for MAPKAP kinase 2","volume":"275","author":"Maulik N.","year":"1998","unstructured":"N.\u00a0Maulik, T.\u00a0Yoshida, Y. L.\u00a0Zu, M.\u00a0Sato, A.\u00a0Banerjee, D. K.\u00a0Das, Ischemic preconditioning triggers tyrosine kinase signaling: A potential role for MAPKAP kinase 2. Am.\u00a0J.\u00a0Physiol. 275, H1857\u2013H1864 (1998).","journal-title":"Am.\u00a0J.\u00a0Physiol."},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.10.021"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5296.90"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.11.019"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2867"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1346"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6205"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(00)00019-9"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00053.x"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy146"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.03.002"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00843-2"},{"key":"e_1_3_4_104_2","unstructured":"J.\u00a0J.\u00a0Alam et\u00a0al. paper presented at the Clinical Trials on Alzheimer\u2019s Disease Digital conference 4 to 7 November 2020."},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-012-0104-2"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10231"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2013.07.007"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.01.010"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01888-0"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00286"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay0399"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2534"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.abq6089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:49:01Z","timestamp":1705427341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abq6089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":111,"journal-issue":{"issue":"695","published-print":{"date-parts":[[2023,5,10]]}},"alternative-id":["10.1126\/scitranslmed.abq6089"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.abq6089","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,10]]},"assertion":[{"value":"2022-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eabq6089"}}