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The recent cases of MARV in West Africa underscore the substantial outbreak potential of this virus. The potential for cross-border spread, as had occurred during the 2014\u20132016 Ebola virus outbreak, illustrates the critical need for MARV vaccines. To support regulatory approval of the chimpanzee adenovirus 3 (ChAd3)\u2013MARV vaccine that has completed phase 1 trials, we showed that the nonreplicating ChAd3 vector, which has a demonstrated safety profile in humans, protected against a uniformly lethal challenge with MARV\/Ang. Protective immunity was achieved within 7 days of vaccination and was maintained through 1 year after vaccination. Antigen-specific antibodies were an immune correlate of protection in the acute challenge model, and their concentration was predictive of protection. These results demonstrate that a single-shot ChAd3-MARV vaccine generated a protective immune response that was both rapid and durable with an immune correlate of protection that will support advanced clinical development.<\/jats:p>","DOI":"10.1126\/scitranslmed.abq6364","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T18:59:23Z","timestamp":1671044363000},"source":"Crossref","is-referenced-by-count":35,"title":["A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-5245","authenticated-orcid":true,"given":"Ruth","family":"Hunegnaw","sequence":"first","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, 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