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In this study, we investigated the impact of prior DENV infection or no DENV infection on ZIKV pathogenesis during pregnancy in a total of four female common marmosets with five or six fetuses per group. The results showed that negative-sense viral RNA copies increased in the placental and fetal tissues of DENV-immune dams but not in DENV-na\u00efve dams. In addition, viral proteins were prevalent in endothelial cells, macrophages, and neonatal Fc receptor\u2013expressing cells in the placental trabeculae and in neuronal cells in the brains of fetuses from DENV-immune dams. DENV-immune marmosets maintained high titers of cross-reactive ZIKV-binding antibodies that were poorly neutralizing, raising the possibility that these antibodies might be involved in the exacerbation of ZIKV infection. These findings need to be verified in a larger study, and the mechanism involved in the exacerbation of ZIKV infection in DENV-immune marmosets needs further investigation. However, the results suggest a potential negative impact of preexisting DENV immunity on subsequent ZIKV infection during pregnancy in vivo.<\/jats:p>","DOI":"10.1126\/scitranslmed.abq6517","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T17:58:12Z","timestamp":1686160692000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["Impact of prior dengue virus infection on Zika virus infection during pregnancy in marmosets"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-9589","authenticated-orcid":true,"given":"In-Jeong","family":"Kim","sequence":"first","affiliation":[{"name":"Trudeau Institute Inc., Saranac Lake, NY 12983, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-5688","authenticated-orcid":true,"given":"Michael 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