{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:19:22Z","timestamp":1792696762446,"version":"4.5.0"},"reference-count":84,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"674","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2022,12,7]]},"abstract":"<jats:p>\n            The lung naturally resists\n            <jats:italic>Aspergillus fumigatus<\/jats:italic>\n            (\n            <jats:italic>Af<\/jats:italic>\n            ) in healthy individuals, but multiple conditions can disrupt this resistance, leading to lethal invasive infections. Core processes of natural resistance and its breakdown are undefined. We investigated three distinct conditions predisposing to lethal aspergillosis\u2014severe SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection, influenza A viral pneumonia, and systemic corticosteroid use\u2014in human patients and murine models. We found a conserved and essential coupling of innate B1a lymphocytes,\n            <jats:italic>Af<\/jats:italic>\n            -binding natural immunoglobulin G antibodies, and lung neutrophils. Failure of this axis concealed\n            <jats:italic>Af<\/jats:italic>\n            from neutrophils, allowing rapid fungal invasion and disease. Reconstituting the axis with immunoglobulin therapy reestablished resistance, thus representing a realistic pathway to repurpose currently available therapies. Together, we report a vital host resistance pathway that is responsible for protecting against life-threatening aspergillosis in the context of distinct susceptibilities.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.abq6682","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T18:58:12Z","timestamp":1670439492000},"source":"Crossref","is-referenced-by-count":55,"title":["A B1a\u2013natural IgG\u2013neutrophil axis is impaired in viral- and steroid-associated aspergillosis"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-8651","authenticated-orcid":true,"given":"Nicole","family":"Sarden","sequence":"first","affiliation":[{"name":"Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada."},{"name":"Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, 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