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The technology is mechanically transparent when unpowered, can quantitatively assess free movement of the user, and adds only 150\u00a0grams of weight to each upper limb. In 10 individuals with amyotrophic lateral sclerosis (ALS) with different degrees of neuromuscular impairment, we demonstrated immediate improvement in the active range of motion and compensation for continuing physical deterioration in two individuals with ALS over 6 months. Along with improvements in movement, we show that this robotic wearable can improve functional activity without any training, restoring performance of basic activities of daily living. In addition, a reduction in shoulder muscle activity and perceived muscular exertion, coupled with increased endurance for holding objects, highlight the potential of this device to mitigate the impact of muscular fatigue for patients with ALS. These results represent a further step toward everyday use of assistive, soft, robotic wearables for the upper limbs.<\/jats:p>","DOI":"10.1126\/scitranslmed.add1504","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:58:18Z","timestamp":1675277898000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":105,"title":["Restoring arm function with a soft robotic wearable for individuals with amyotrophic lateral sclerosis"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8875-8646","authenticated-orcid":true,"given":"Tommaso","family":"Proietti","sequence":"first","affiliation":[{"name":"John A.\u00a0Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-9985","authenticated-orcid":true,"given":"Ciaran","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"John A.\u00a0Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-4672","authenticated-orcid":true,"given":"Lucas","family":"Gerez","sequence":"additional","affiliation":[{"name":"John A.\u00a0Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tazzy","family":"Cole","sequence":"additional","affiliation":[{"name":"John A.\u00a0Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mendelowitz","sequence":"additional","affiliation":[{"name":"John A.\u00a0Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Nuckols","sequence":"additional","affiliation":[{"name":"John A.\u00a0Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2259-8720","authenticated-orcid":true,"given":"Cameron","family":"Hohimer","sequence":"additional","affiliation":[{"name":"John A.\u00a0Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6575-9849","authenticated-orcid":true,"given":"David","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-1168","authenticated-orcid":true,"given":"Sabrina","family":"Paganoni","sequence":"additional","affiliation":[{"name":"Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, MA 02114, USA."},{"name":"Department of Physical Medicine and Rehabilitation Services, Spaulding Rehabilitation Hospital, Boston, MA 02129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-917X","authenticated-orcid":true,"given":"Conor","family":"Walsh","sequence":"additional","affiliation":[{"name":"John A.\u00a0Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","unstructured":"The ALS Association (28 July 2021) www.als.org\/."},{"key":"e_1_3_3_3_2","unstructured":"H. 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