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Repeated malaria exposure was associated with expansion of an atypical, CD56\n            <jats:sup>neg<\/jats:sup>\n            population of NK cells that differed transcriptionally, epigenetically, and phenotypically from CD56\n            <jats:sup>dim<\/jats:sup>\n            NK cells, including decreased expression of PLZF and the Fc receptor \u03b3-chain, increased histone methylation, and increased protein expression of LAG-3, KIR, and LILRB1. CD56\n            <jats:sup>neg<\/jats:sup>\n            NK cells were highly functional and displayed greater antibody-dependent cellular cytotoxicity than CD56\n            <jats:sup>dim<\/jats:sup>\n            NK cells. Higher frequencies of CD56\n            <jats:sup>neg<\/jats:sup>\n            NK cells were associated with protection against symptomatic malaria and high parasite densities. After marked reductions in malaria transmission, frequencies of these cells rapidly declined, suggesting that continuous exposure to\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            is required to maintain this modified, adaptive-like NK cell subset.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.add9012","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T18:58:12Z","timestamp":1674673092000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":53,"title":["Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7714","authenticated-orcid":true,"given":"Maureen","family":"Ty","sequence":"first","affiliation":[{"name":"Department of Medicine, Stanford University, Stanford, CA, 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Fairhurst J.\u00a0E.\u00a0Connolly LAG3 is a central regulator of NK cell cytokine production. bioRxiv 2020.01.31.928200 [Preprint]. 2 February 2020. https:\/\/doi.org\/10.1101\/2020.01.31.928200.","DOI":"10.1101\/2020.01.31.928200"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125916"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.05.001"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000699"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281675"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.008"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.079"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34081"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxs080"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0250"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-077438"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216374"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-158"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24994"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03378-6"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00847-4"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31640-6"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02511-5"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21402-1"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0082-6"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.11.005"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir872"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.576663"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-022-04098-6"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa698"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3646"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0439-x"},{"key":"e_1_3_3_61_2","doi-asserted-by":"crossref","unstructured":"L. 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