{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:01:28Z","timestamp":1792814488327,"version":"4.5.0"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"711","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,8,30]]},"abstract":"<jats:p>Myeloid cells in the tumor microenvironment (TME) can exist in immunosuppressive and immunostimulatory states that impede or promote antitumor immunity, respectively. Blocking suppressive myeloid cells or increasing stimulatory cells to enhance antitumor immune responses is an area of interest for therapeutic intervention. Triggering receptor expressed on myeloid cells-1 (TREM1) is a proinflammatory receptor that amplifies immune responses. TREM1 is expressed on neutrophils, subsets of monocytes and tissue macrophages, and suppressive myeloid populations in the TME, including tumor-associated neutrophils, monocytes, and tumor-associated macrophages. Depletion or inhibition of immunosuppressive myeloid cells, or stimulation by TREM1-mediated inflammatory signaling, could be used to promote an immunostimulatory TME. We developed PY159, an afucosylated humanized anti-TREM1 monoclonal antibody with enhanced Fc\u03b3R binding. PY159 is a TREM1 agonist that induces signaling, leading to up-regulation of costimulatory molecules on monocytes and macrophages, production of proinflammatory cytokines and chemokines, and enhancement of T cell activation in vitro. An antibody against mouse TREM1, PY159m, promoted antitumor efficacy in syngeneic mouse tumor models. These results suggest that PY159-mediated agonism of TREM1 on tumoral myeloid cells can promote a proinflammatory TME and offer a promising strategy for immunotherapy.<\/jats:p>","DOI":"10.1126\/scitranslmed.add9990","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:59:22Z","timestamp":1693418362000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":51,"title":["TREM1 activation of myeloid cells promotes antitumor immunity"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3324-0847","authenticated-orcid":true,"given":"Vladislava","family":"Juric","sequence":"first","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Mayes","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Binnewies","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Lee","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Canaday","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Pollack","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-8316","authenticated-orcid":true,"given":"Joshua","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Du","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria M.","family":"Liu","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadra","family":"Dash","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Palmer","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine S.","family":"Jahchan","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa Johanna","family":"Ramoth","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Lacayo","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Mankikar","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manith","family":"Norng","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1200-998X","authenticated-orcid":true,"given":"Chris","family":"Brassell","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aritra","family":"Pal","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chan","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-5146","authenticated-orcid":true,"given":"Erick","family":"Lu","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5258","authenticated-orcid":true,"given":"Venkataraman","family":"Sriram","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-4065","authenticated-orcid":true,"given":"Michel","family":"Streuli","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-3533","authenticated-orcid":true,"given":"Matthew F.","family":"Krummel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California, San\u00a0Francisco, San\u00a0Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2658-7511","authenticated-orcid":true,"given":"Kevin P.","family":"Baker","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-1450","authenticated-orcid":true,"given":"Linda","family":"Liang","sequence":"additional","affiliation":[{"name":"Pionyr Immunotherapeutics, 2 Tower Place, Suite 800, South San\u00a0Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00113"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0041"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.169"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0333-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0281-y"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01977"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01611"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0127-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00620-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00737-w"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.4991"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/35074114"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4956"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3812"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.07.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.043"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0938"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402303"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134172"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.11.021"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3VMA0918-375R"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102674"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000078"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep38275"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64181"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28556"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003900"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051337"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094241"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242709"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-292136"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.1043893"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.662723"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.06.009"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14516-4"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21409"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2018.1466767"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108455108"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700116"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202069200"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1159\/000231973"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.28"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009483200"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02424-0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14572"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00351"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.004"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601473"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.22771"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.518"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.4161\/mco.29899"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.300"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00045-X"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.135"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1086\/374754"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00083"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-062518-045435"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109844"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1108689"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.add9990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:10:36Z","timestamp":1705428636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.add9990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":61,"journal-issue":{"issue":"711","published-print":{"date-parts":[[2023,8,30]]}},"alternative-id":["10.1126\/scitranslmed.add9990"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.add9990","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,30]]},"assertion":[{"value":"2022-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadd9990"}}