{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:47:32Z","timestamp":1792853252113,"version":"4.5.0"},"reference-count":37,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"704","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,7,12]]},"abstract":"<jats:p>\n                    There are no licensed vaccines against\n                    <jats:italic>Plasmodium vivax<\/jats:italic>\n                    . We conducted two phase 1\/2a clinical trials to assess two vaccines targeting\n                    <jats:italic>P. vivax<\/jats:italic>\n                    Duffy-binding protein region II (PvDBPII). Recombinant viral vaccines using chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) vectors as well as a protein and adjuvant formulation (PvDBPII\/Matrix-M) were tested in both a standard and a delayed dosing regimen. Volunteers underwent controlled human malaria infection (CHMI) after their last vaccination, alongside unvaccinated controls. Efficacy was assessed by comparisons of parasite multiplication rates in the blood. PvDBPII\/Matrix-M, given in a delayed dosing regimen, elicited the highest antibody responses and reduced the mean parasite multiplication rate after CHMI by 51% (\n                    <jats:italic>n<\/jats:italic>\n                    = 6) compared with unvaccinated controls (\n                    <jats:italic>n<\/jats:italic>\n                    = 13), whereas no other vaccine or regimen affected parasite growth. Both viral-vectored and protein vaccines were well tolerated and elicited expected, short-lived adverse events. Together, these results support further clinical evaluation of the PvDBPII\/Matrix-M\n                    <jats:italic>P. vivax<\/jats:italic>\n                    vaccine.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adf1782","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T13:59:06Z","timestamp":1689170346000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":45,"title":["Vaccination with\n                    <i>Plasmodium vivax<\/i>\n                    Duffy-binding protein inhibits parasite growth during controlled human malaria infection"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-9147","authenticated-orcid":true,"given":"Mimi M.","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK."},{"name":"Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK."},{"name":"Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford OX1 3QU, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0746-1945","authenticated-orcid":true,"given":"Jordan R.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK."},{"name":"Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK."},{"name":"Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford OX1 3QU, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9285-6639","authenticated-orcid":true,"given":"Yrene","family":"Themistocleous","sequence":"additional","affiliation":[{"name":"Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Rawlinson","sequence":"additional","affiliation":[{"name":"Jenner 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