{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:23:55Z","timestamp":1791822235256,"version":"4.3.4"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"708","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,8,9]]},"abstract":"<jats:p>Oncomodulin (Ocm) is a myeloid cell\u2013derived growth factor that enables axon regeneration in mice and rats after optic nerve injury or peripheral nerve injury, yet the mechanisms underlying its activity are unknown. Using proximity biotinylation, coimmunoprecipitation, surface plasmon resonance, and ectopic expression, we have identified armadillo-repeat protein C10 (ArmC10) as a high-affinity receptor for Ocm. ArmC10 deletion suppressed inflammation-induced axon regeneration in the injured optic nerves of mice. ArmC10 deletion also suppressed the ability of lesioned sensory neurons to regenerate peripheral axons rapidly after a second injury and to regenerate their central axons after spinal cord injury in mice (the conditioning lesion effect). Conversely, Ocm acted through ArmC10 to accelerate optic nerve and peripheral nerve regeneration and to enable spinal cord axon regeneration in these mouse nerve injury models. We showed that ArmC10 is highly expressed in human-induced pluripotent stem cell\u2013derived sensory neurons and that exposure to Ocm altered gene expression and enhanced neurite outgrowth. ArmC10 was also expressed in human monocytes, and Ocm increased the expression of immune modulatory genes in these cells. These findings suggest that Ocm acting through its receptor ArmC10 may be a useful therapeutic target for nerve repair and immune modulation.<\/jats:p>","DOI":"10.1126\/scitranslmed.adg6241","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T17:58:40Z","timestamp":1691603920000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":22,"title":["The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC\u2013derived sensory neurons"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-1482","authenticated-orcid":true,"given":"Lili","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."},{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-6954","authenticated-orcid":true,"given":"Yuqin","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."},{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-6408","authenticated-orcid":true,"given":"Selwyn","family":"Jayakar","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Neurology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riki","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Psychiatry and Human Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Psychiatry and Human Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."},{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb","family":"Shi","sequence":"additional","affiliation":[{"name":"Harvard College, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-8394","authenticated-orcid":true,"given":"Bruna Lenfers","family":"Turnes","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Neurology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-8101","authenticated-orcid":true,"given":"Zihe","family":"Zhang","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Neurology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4759-2341","authenticated-orcid":true,"given":"Juan","family":"Oses-Prieto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, UCSF, Mission Bay Campus, San\u00a0Francisco, CA, 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3630-0251","authenticated-orcid":true,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation and Immunity, Brigham and Women\u2019s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-7307","authenticated-orcid":true,"given":"Al","family":"Burlingame","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, UCSF, Mission Bay Campus, San\u00a0Francisco, CA, 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-3897","authenticated-orcid":true,"given":"Clifford J.","family":"Woolf","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Neurology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-3450","authenticated-orcid":true,"given":"Daniel","family":"Geschwind","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Psychiatry and Human Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Rasband","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0277-7222","authenticated-orcid":true,"given":"Larry I.","family":"Benowitz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."},{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"S. Ramon y Cajal Degeneration and Regeneration of the Nervous System . J.\u00a0D.\u00a0A.\u00a0E.\u00a0G. Jones Eds. History of Neuroscience (Oxford Univ. Press 1991) vol. 5.","DOI":"10.1093\/acprof:oso\/9780195065169.001.0001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80755-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3319-12.2013"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0278-13.2013"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1924-15.2015"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/330658a0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90085-T"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1447-08.2008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02284.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423221112"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-04-00972.1991"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1701"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5511-12.2013"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907085106"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0477-21.2022"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113751119"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4533"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.121"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08004-0"},{"key":"e_1_3_2_21_2","first-page":"174","article-title":"Optic nerve regeneration in the mouse is a complex trait modulated by genetic background","volume":"24","author":"Wang J.","year":"2018","unstructured":"J.\u00a0Wang, Y.\u00a0Li, R.\u00a0King, F. L.\u00a0Struebing, E. E.\u00a0Geisert, Optic nerve regeneration in the mouse is a complex trait modulated by genetic background. Mol. Vis. 24, 174\u2013186 (2018).","journal-title":"Mol. Vis."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00813-0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4340-10.2010"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25209"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5313-06.2007"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002680"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4473-12.2015"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007467"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2023.03.006"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001217"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj8186"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026620666201202102448"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.07.026"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66092-9"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00047"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161566"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.04.028"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf7266"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.11.003"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3978"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00557-7"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017282118"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-022720-094953"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.005"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.12.015"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.002"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.022"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.04.033"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2007.08.009"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22634"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0262"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00084-2"},{"key":"e_1_3_2_53_2","first-page":"e1020","article-title":"Cell surface protein-protein binding on COS-7 cells","volume":"4","author":"Chang K. J.","year":"2015","unstructured":"K. J.\u00a0Chang, M. N.\u00a0Rasband, Cell surface protein-protein binding on COS-7 cells. Bio Protoc. 4, e1020 (2015).","journal-title":"Bio Protoc."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(92)90061-B"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.010728"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac9810516"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00005-1"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-01-00339.1988"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(87)90012-X"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adg6241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:51:00Z","timestamp":1705427460000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adg6241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":60,"journal-issue":{"issue":"708","published-print":{"date-parts":[[2023,8,9]]}},"alternative-id":["10.1126\/scitranslmed.adg6241"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adg6241","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]},"assertion":[{"value":"2023-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadg6241"}}