{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:20:17Z","timestamp":1792822817753,"version":"4.5.0"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"703","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:p>\n                    Broadly neutralizing antibodies (bNAbs) may provide an alternative to standard antiretroviral treatment (ART) for controlling HIV-1 replication and may have immunotherapeutic effects against HIV-1 reservoirs. We conducted a prospective clinical trial with two HIV-1 bNAbs (VRC01LS and 10-1074) in children (\n                    <jats:italic>n<\/jats:italic>\n                    = 25) who had previously initiated small-molecule ART treatment before 7 days of age and who continued treatment for at least 96 weeks. Both bNAbs were dosed intravenously every 4 weeks, overlapping with ART for at least 8 weeks and then continued for up to 24 weeks or until detectable viremia of HIV-1 RNA rose above 400 copies per milliliter in the absence of ART. Eleven (44%) children maintained HIV-1 RNA below 400 copies per milliliter through 24 weeks of bNAb-only treatment; 14 (56%) had detectable viremia above 400 copies per milliliter at a median of 4 weeks. Archived HIV-1 provirus susceptible to 10-1074, lower birth HIV-1 DNA reservoir in peripheral blood mononuclear cells, sustained viral suppression throughout early life, and combined negative qualitative HIV-1 DNA polymerase chain reaction and negative HIV-1 serology at entry were associated with maintaining suppression on bNAbs alone. This proof-of-concept study suggests that bNAbs may represent a promising treatment modality for infants and children living with HIV-1. Future studies using newer bNAb combinations with greater breadth and potency are warranted.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adh0004","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:58:13Z","timestamp":1688565493000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":52,"title":["Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-6275","authenticated-orcid":true,"given":"Roger L.","family":"Shapiro","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."},{"name":"Botswana Harvard Health Partnership, Gaborone, Botswana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-4823","authenticated-orcid":true,"given":"Gbolahan","family":"Ajibola","sequence":"additional","affiliation":[{"name":"Botswana Harvard Health Partnership, Gaborone, Botswana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-4637","authenticated-orcid":true,"given":"Kenneth","family":"Maswabi","sequence":"additional","affiliation":[{"name":"Botswana Harvard Health Partnership, Gaborone, Botswana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4964-067X","authenticated-orcid":true,"given":"Bryan S.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7082-3191","authenticated-orcid":true,"given":"Aischa","family":"Niesar","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Pretorius Holme","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-4471","authenticated-orcid":true,"given":"Kathleen M.","family":"Powis","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T. H. 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