{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:07:51Z","timestamp":1792822071900,"version":"4.5.0"},"reference-count":77,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"729","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2024,1,10]]},"abstract":"<jats:p>\n            The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with argininosuccinic aciduria, an inherited metabolic disease with hyperammonemia and a systemic phenotype coinciding with neurocognitive impairment and chronic liver disease. Here, we describe the dysregulation of glutathione biosynthesis and upstream cysteine utilization in ASL-deficient patients and mice using targeted metabolomics and in vivo positron emission tomography (PET) imaging using (\n            <jats:italic>S<\/jats:italic>\n            )-4-(3-\n            <jats:sup>18<\/jats:sup>\n            F-fluoropropyl)-\n            <jats:sc>l<\/jats:sc>\n            -glutamate ([\n            <jats:sup>18<\/jats:sup>\n            F]FSPG). Up-regulation of cysteine metabolism contrasted with glutathione depletion and down-regulated antioxidant pathways. To assess hepatic glutathione dysregulation and liver disease, we present [\n            <jats:sup>18<\/jats:sup>\n            F]FSPG PET as a noninvasive diagnostic tool to monitor therapeutic response in argininosuccinic aciduria. Human\n            <jats:italic>hASL<\/jats:italic>\n            mRNA encapsulated in lipid nanoparticles improved glutathione metabolism and chronic liver disease. In addition,\n            <jats:italic>hASL<\/jats:italic>\n            mRNA therapy corrected and rescued the neonatal and adult Asl-deficient mouse phenotypes, respectively, enhancing ureagenesis. These findings provide mechanistic insights in liver glutathione metabolism and support clinical translation of mRNA therapy for argininosuccinic aciduria.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.adh1334","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T18:58:47Z","timestamp":1704913127000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":35,"title":["mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3271-5273","authenticated-orcid":true,"given":"Sonam","family":"Gurung","sequence":"first","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4187-1588","authenticated-orcid":true,"given":"Oskar Vilhelmsson","family":"Timmermand","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, London SE1 7EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5450-8801","authenticated-orcid":true,"given":"Dany","family":"Perocheau","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-5676","authenticated-orcid":true,"given":"Ana Luisa","family":"Gil-Martinez","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Minnion","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loukia","family":"Touramanidou","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Fang","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-0922","authenticated-orcid":true,"given":"Martina","family":"Messina","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-3017","authenticated-orcid":true,"given":"Youssef","family":"Khalil","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Spiewak","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0238-2686","authenticated-orcid":true,"given":"Abigail R.","family":"Barber","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, London SE1 7EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9178-7691","authenticated-orcid":true,"given":"Richard S.","family":"Edwards","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, London SE1 7EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-7586","authenticated-orcid":true,"given":"Patricia Lipari","family":"Pinto","sequence":"additional","affiliation":[{"name":"Santa Maria\u2019s Hospital, Lisbon North University Hospital Center, 1649-028 Lisbon, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-5400","authenticated-orcid":true,"given":"Patrick F.","family":"Finn","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1226-5704","authenticated-orcid":true,"given":"Alex","family":"Cavedon","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summar","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Rice","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-797X","authenticated-orcid":true,"given":"Paolo G. V.","family":"Martini","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-6450","authenticated-orcid":true,"given":"Deborah","family":"Ridout","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Heywood","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"Pharmacy and Biomolecular Sciences, Liverpool John Moore University, Liverpool L3 5UG, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-0200","authenticated-orcid":true,"given":"Simon","family":"Heales","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."},{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa B.","family":"Mills","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-4730","authenticated-orcid":true,"given":"Simon N.","family":"Waddington","sequence":"additional","affiliation":[{"name":"EGA Institute for Women\u2019s Health, University College London, London WC1E 6HX, UK."},{"name":"Wits\/SAMRC Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of Witswatersrand, Braamfontein, 2000 Johannesburg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9712-6122","authenticated-orcid":true,"given":"Paul","family":"Gissen","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."},{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK."},{"name":"National Institute of Health Research Great Ormond Street Biomedical Research Centre, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-9204","authenticated-orcid":true,"given":"Simon","family":"Eaton","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-6957","authenticated-orcid":true,"given":"Mina","family":"Ryten","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-1158","authenticated-orcid":true,"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK."},{"name":"Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Frassetto","sequence":"additional","affiliation":[{"name":"Moderna Inc., Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9475-2873","authenticated-orcid":true,"given":"Timothy H.","family":"Witney","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, London SE1 7EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-540X","authenticated-orcid":true,"given":"Julien","family":"Baruteau","sequence":"additional","affiliation":[{"name":"Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK."},{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK."},{"name":"National Institute of Health Research Great Ormond Street Biomedical Research Centre, London WC1N 1EH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.07.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12047"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.166"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2544"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.03.018"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202013158"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01825-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05972-1"},{"key":"e_1_3_2_11_2","unstructured":"L. Touramanidou D. Perocheau S. Gurung A. C. Cozmescu S. N. Waddington J. R. Counsell P. Gissen J. Baruteau In vivo lentiviral gene therapy for argininosuccinic aciduria. Hum. Gene Ther. 32 A104 (2021)."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132342"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2018.08.013"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12144"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0088-5"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0022-x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2021.04.001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2008.05.004"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3180ca8720"},{"key":"e_1_3_2_20_2","first-page":"136","article-title":"Severe liver fibrosis in argininosuccinic aciduria","volume":"110","author":"Zimmermann A.","year":"1986","unstructured":"A. Zimmermann, C. Bachmann, R. Baumgartner, Severe liver fibrosis in argininosuccinic aciduria. Arch. Pathol. Lab. Med. 110, 136\u2013140 (1986).","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.09.016"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.08.021"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.07.008"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7083"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd9847"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.05.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-015-9840-x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14017"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-756-3_18"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2634"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-018-0288-x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3423"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.63237"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0214"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1080-1"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.081"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19156-3"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1998.0854"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00371-3"},{"key":"e_1_3_2_40_2","first-page":"623","article-title":"Systems redox biology in health and disease","volume":"21","author":"Feelisch M.","year":"2022","unstructured":"M. Feelisch, M. M. Cortese-Krott, J. Santolini, S. A. Wootton, A. A. Jackson, Systems redox biology in health and disease. EXCLI J. 21, 623\u2013646 (2022).","journal-title":"EXCLI J."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(95)51106-7"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030364"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.7923"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.11.010"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1159\/000468630"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308601300185179"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.053"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.043"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-021-02345-5"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00403.2013"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138935"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-016-1007-0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0199-z"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0053-3"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2020.182"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2021.29182.bfs"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006419"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4278"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318269"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2022.03.005"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.628137"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.003"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctd2.33"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.04.012"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1906182116"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-7192(02)00206-8"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz6893"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-021-01609-w"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.228692"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-016-9935-z"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406075101"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101907"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.02.012"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.139"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_77_2","unstructured":"H. Wickham \u201cggplot2: Elegant graphics for data analysis\u201d (Springer-Verlag New York ISBN 978-3-319-24277-4 2016); https:\/\/ggplot2.tidyverse.org."},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12575-016-0045-y"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.adh1334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T18:59:12Z","timestamp":1704913152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adh1334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":77,"journal-issue":{"issue":"729","published-print":{"date-parts":[[2024,1,10]]}},"alternative-id":["10.1126\/scitranslmed.adh1334"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.adh1334","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2023-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadh1334"}}