{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:21:27Z","timestamp":1792113687067,"version":"4.4.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"718","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2023,10,18]]},"abstract":"<jats:p>\n                    <jats:italic>Leishmania braziliensis<\/jats:italic>\n                    is a parasitic infection that can result in inflammation and skin injury with highly variable and unpredictable clinical outcomes. Here, we investigated the potential impact of microbiota on infection-induced inflammatory responses and disease resolution by conducting an integrated analysis of the skin microbiome and host transcriptome on a cohort of 62 patients infected with\n                    <jats:italic>L. braziliensis<\/jats:italic>\n                    . We found that overall bacterial burden and microbiome configurations dominated with\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    spp. were associated with delayed healing and enhanced inflammatory responses, especially by IL-1 family members. Quantification of host and bacterial transcripts on human lesions revealed that high lesional\n                    <jats:italic>S. aureus<\/jats:italic>\n                    transcript abundance was associated with delayed healing and increased expression of IL-1\u03b2. This cytokine was critical for modulating disease outcomes in\n                    <jats:italic>L. braziliensis<\/jats:italic>\n                    \u2013infected mice colonized with\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , given that its neutralization reduced pathology and inflammation. These results highlight how the human microbiome can shape disease outcomes in cutaneous leishmaniasis and suggest pathways toward host-directed therapies to mitigate the inflammatory consequences.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.adh1469","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T13:58:55Z","timestamp":1697637535000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":33,"title":["Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-7265","authenticated-orcid":true,"given":"Camila","family":"Farias Amorim","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria M.","family":"Lovins","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tej Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-0384","authenticated-orcid":true,"given":"Fernanda O.","family":"Novais","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, College of Medicine, Ohio State University, Columbus, OH 43210, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan C.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4586-0322","authenticated-orcid":true,"given":"Alexsandro S.","family":"Lago","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas Cl\u00ednicas do Instituto de Pesquisas Gon\u00e7alo Muniz\u2013Fiocruz, Salvador, Bahia 40296-710, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-1666","authenticated-orcid":true,"given":"Lucas P.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas Cl\u00ednicas do Instituto de Pesquisas Gon\u00e7alo Muniz\u2013Fiocruz, Salvador, Bahia 40296-710, Brazil."},{"name":"Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia 40110-060, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-8002","authenticated-orcid":true,"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas Cl\u00ednicas do Instituto de Pesquisas Gon\u00e7alo Muniz\u2013Fiocruz, Salvador, Bahia 40296-710, Brazil."},{"name":"Immunology Service, Professor Edgard Santos University Hospital Complex, Federal University of Bahia, Salvador, Bahia 40110-060, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2865-4589","authenticated-orcid":true,"given":"Daniel P.","family":"Beiting","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-0653","authenticated-orcid":true,"given":"Phillip","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3939-2200","authenticated-orcid":true,"given":"Elizabeth A.","family":"Grice","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2608"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.72"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1997.57.651"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.574"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo0693"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"a041218","DOI":"10.1101\/cshperspect.a041218","article-title":"The wound microbiome","volume":"15","author":"White E. 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